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  • 1
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    Online Resource
    Global impact of COVID-19 on stroke care
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 5 ( 2021-07), p. 573-584
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 5 ( 2021-07), p. 573-584
    Abstract: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p  〈  0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493021991652
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 2
    Online Resource
    Online Resource
    Advanced glycation end products are associated with immature angiogenesis and peritoneal dysfunction in patients on peritoneal dialysis
    SAGE Publications ; 2020
    In:  Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis Vol. 40, No. 1 ( 2020-01), p. 67-75
    Details
    In: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, SAGE Publications, Vol. 40, No. 1 ( 2020-01), p. 67-75
    Abstract: Deposition of advanced glycation end products (AGEs) is frequently found in the peritoneum of patients on peritoneal dialysis (PD). Angiogenesis is also observed in the peritoneum. However, the clinical significance of AGEs and angiogenesis in the peritoneum is not fully understood. We evaluated the maturation of capillary vessels and investigated whether AGEs are associated with angiogenesis and peritoneal function in the peritoneal membrane. Methods: Peritoneum obtained when PD catheters were removed from 61 patients with PD was analyzed. The peritoneum was immunohistochemically stained with anti-CD34 (for endothelial cells), anti-alpha smooth muscle actin (αSMA) (for pericytes), and anti-AGE antibodies. We defined CD34-positive and αSMA-negative vessels as immature capillary vessels in peritoneal membranes using serial sections. We evaluated the associations between vessel density, peritoneal function (dialysate-to-plasma ratio for creatinine (D/P creatinine)), and the degree of AGE deposition. Results: AGE accumulation in the interstitium was positively associated with the duration of PD ( p 〈 0.01). AGE accumulation in the interstitium and vascular wall was positively correlated with the use of acidic solution ( p 〈 0.05) and the maximum value of D/P creatinine ( p 〈 0.05). AGE accumulation in the vascular wall was significantly associated with immature capillary density (CD34+/αSMA−) in the peritoneum ( p 〈 0.01). Vessel density was not significantly correlated with the last measurement of D/P creatinine ( p = 0.126, r = 0.202), However, immature capillary density was positively correlated with the last measurement of D/P creatinine ( p 〈 0.05, r = 0.278). Conclusions: AGE accumulation is significantly associated with immature angiogenesis and peritoneal dysfunction in patients undergoing PD.
    Type of Medium: Online Resource
    ISSN: 0896-8608 , 1718-4304
    URL: Article
    DOI: 10.1177/0896860819878344
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2075957-5
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  • 3
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    Online Resource
    Somnolence and Dizziness During Mirogabalin Treatment in Patients With Neuropathic Pain Related to Lumbar Disease Who Switched From Pregabalin: A Retrospective Study
    SAGE Publications ; 2023
    In:  Global Spine Journal Vol. 13, No. 5 ( 2023-06), p. 1319-1324
    Details
    In: Global Spine Journal, SAGE Publications, Vol. 13, No. 5 ( 2023-06), p. 1319-1324
    Abstract: Multicenter retrospective study. Objectives: To investigate adverse events (AEs) in patients with neuropathic pain related to lumbar disease who switched to mirogabalin from pregabalin. Methods: This study surveyed the records of 82 patients with peripheral neuropathic leg pain related to lumbar disease who switched to mirogabalin from pregabalin. We evaluated AEs associated with pregabalin and mirogabalin, the continuation rate of mirogabalin, and the pain-relieving effect at 4 weeks after switching from pregabalin to mirogabalin. We compared patients who switched due to lack of efficacy (LoE group) and patients who switched due to AEs (AE group). Results: The incidence rates of somnolence and dizziness with pregabalin were 12.2% and 14.6%, respectively, while the incidence rates with mirogabalin were reduced to 7.3% for somnolence and 4.9% for dizziness. The incidence of AEs with pregabalin was significantly higher in the AE group (LoE group: 11.1%, AE group 100%), especially for somnolence (LoE group: 3.2%, AE group: 47.1%) and dizziness (LoE group: 4.8%, AE: 52.9%). After switching, the incidences of AEs with mirogabalin were not significantly different between the 2 groups (LoE group: 15.9%, AE group: 23.5%), including for somnolence (LoE group: 7.9%, AE group: 5.9%) and dizziness (LoE group: 4.8%, AE group: 5.9%). There were no significant differences in continuation rate of mirogabalin or the pain-relieving effect between groups. Conclusions: The patients who experience somnolence and dizziness with pregabalin might be able to continue safely receiving treatment for their pain by switching to mirogabalin.
    Type of Medium: Online Resource
    ISSN: 2192-5682 , 2192-5690
    URL: Article
    DOI: 10.1177/21925682211031185
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2648287-3
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  • 4
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    Online Resource
    Surgical strategy for treating mycotic aneurysms of thoracic and abdominal aorta and iliac artery: Analysis of long-term follow-up data
    SAGE Publications ; 2022
    In:  Asian Cardiovascular and Thoracic Annals Vol. 30, No. 8 ( 2022-10), p. 906-911
    Details
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 30, No. 8 ( 2022-10), p. 906-911
    Abstract: Mycotic aneurysms of the aorta and iliac arteries are rare, but life-threatening conditions. We reviewed our experience to determine the best surgical strategy. Between 2007 and 2015, we operated 14 patients with mycotic aneurysms of the aortic arch ( n  =  6), descending aorta ( n  =  1), thoracoabdominal aorta ( n  =  2), abdominal aorta ( n  =  4), and iliac artery ( n  =  1). The mean age was 70.4  ±  8.8 years, and 10 males were included. Blood culture, tissue culture, or both were positive in 11 patients. Four of five patients with mycotic aneurysms of the abdominal aorta and iliac artery underwent extra-anatomical bypass. Ten underwent in-situ graft replacement for managing mycotic aneurysms of the thoracic aorta. One patient with a mycotic thoracoabdominal aortic aneurysm underwent visceral bypass of the descending aorta and extra-anatomical bypass. Omental pedicle grafting was performed in 10 patients. The mean follow-up period was 8.6  ±  3.1 years. Three patients (21.4%) died. Recurrent infection was observed in one patient with a mycotic aneurysm of iliac artery three months after the initial surgery. The patient underwent extra-anatomical bypass with omental pedicle grafting as a redo. Nine patients were discharged, and no recurrence of infection was observed. Two patients died of cancer and heart failure. The five- and seven-year survival rates were 100% ± 0.0% and 85.7% ± 13.2%, respectively. A combination of radical debridement of the infectious source and omental pedicle grafting with either in-situ graft replacement or extra-anatomical bypass is an effective strategy.
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    URL: Article
    DOI: 10.1177/02184923221119916
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2044527-1
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  • 5
    Online Resource
    Online Resource
    Micro particle image velocimetry investigation of near-wall behaviors of tumble enhanced flow in an internal combustion engine
    SAGE Publications ; 2019
    In:  International Journal of Engine Research Vol. 20, No. 7 ( 2019-09), p. 718-725
    Details
    In: International Journal of Engine Research, SAGE Publications, Vol. 20, No. 7 ( 2019-09), p. 718-725
    Abstract: A micro particle image velocimetry has been performed to investigate tumble enhanced flow characteristics near piston top surface of a motored internal combustion engine for three inlet valve open timing (−30, −15, 0 crank angle degrees). Particle image velocimetry was conducted at 340, 350 and 360 crank angle degrees of the end of the compression stroke at the constant motored speed of 2000 r/min. The measurement region was 3.2 mm × 1.5 mm on the piston top including central axis of the cylinder. The spatial resolution of particle image velocimetry in the wall-normal direction was 75 µm and the vector spacing was 37.5 µm. The first velocity vector is located about 60 µm from the piston top surface. The micro particle image velocimetry measurements revealed that the ensemble-averaged flow near the piston top is not close to the turbulent boundary layer and rather has tendency of the Blasius theorem, whereas fluctuation root-mean-square velocity near the wall is not low. This result shows that revision of a wall heat transfer model based on an assumption of the proper characteristics of flow field near the piston top is required for more accurate prediction of heat flux in gasoline engines.
    Type of Medium: Online Resource
    ISSN: 1468-0874 , 2041-3149
    URL: Article
    DOI: 10.1177/1468087418774710
    RVK:
    ZG 1100
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2030603-9
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  • 6
    Online Resource
    Online Resource
    Feasibility and Benefit of Concurrent Chemoradiotherapy for Elderly Patients with Uterine Cervical Cancer
    SAGE Publications ; 2016
    In:  Tumori Journal Vol. 102, No. 6 ( 2016-11), p. 600-605
    Details
    In: Tumori Journal, SAGE Publications, Vol. 102, No. 6 ( 2016-11), p. 600-605
    Abstract: Elderly patients with uterine cervical cancer reportedly have a poorer prognosis than younger patients. Until now, the benefit of concurrent chemoradiotherapy (CCRT) for elderly patients has been considered limited. Methods We retrospectively analyzed 49 women with cervical cancer aged 〉 70 years primarily treated with radiotherapy (RT) or CCRT in our institute between 2003 and 2014. Treatment compliance, toxicity, and survival benefit were analyzed. Results A total of 49 patients were identified in this retrospective analysis. Twenty patients with a median age of 75.4 years (range 70–77) were treated with CCRT and 29 patients with a median age of 77.9 years (range 70–89) underwent RT. In the CCRT group, 14 patients (70%) completed CCRT consisting of radiotherapy and 5 courses of cisplatin plus 5-fluorouracil including patients requiring a dose reduction of chemotherapy. The median overall survival (OS) in the CCRT and RT groups was 66.9 and 60.1 months, respectively (p = 0.156). The most common grade 3/4 acute toxicity was hyponatremia (35.0%), followed by neutropenia (15.0%) and diarrhea (10.0%) in the CCRT group, while this was anemia (17.2%) followed by radiation enteritis (10.3%) in the RT group. Conclusions CCRT was well tolerated in elderly patients with cervical cancer. Careful attention should be paid to the different characteristics of treatment-related toxicities in this group compared with younger patients.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.5301/tj.5000530
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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