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  • SAGE Publications  (3)
  • English  (3)
  • 1
    Online Resource
    Online Resource
    Neuroprotective effect of apigenin against cerebral ischemia/reperfusion injury
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 9 ( 2020-09), p. 030006052094585-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 9 ( 2020-09), p. 030006052094585-
    Abstract: The therapeutic efficacy of apigenin in PC12 cells and rats remains uncertain. The aim of this study was to investigate the neuroprotective effects of apigenin against cerebral ischemia/reperfusion injury, both in vitro and in vivo. Methods We first treated PC12 cells with cobalt chloride (CoCl 2 ) to create a model of oxidative stress injury. Cell viability was then determined using a multifunctional microplate reader. In addition, reactive oxygen species (ROS) levels, apoptosis, and mitochondrial membrane potentials (MMPs) were examined using high-content cytometer analysis. The efficacy of apigenin treatment was also analyzed in a rat middle cerebral artery occlusion (MCAO) model using TTC staining and neurological deficit scores. Results The half-inhibitory concentration of CoCl 2 was 1.2 mM. Pretreatment with 10 µg ⋅ mL −1 apigenin significantly enhanced cell viability, reduced ROS levels, alleviated apoptosis, and improved MMP in PC12 cells with CoCl 2 -induced injury in vitro. In addition, apigenin treatment in vivo significantly improved neurological deficit scores and reduced infarct areas in MCAO rats. These results suggest that the neuroprotective mechanisms of apigenin may be related to mitochondrial activation. Conclusions Apigenin had excellent neuroprotective effects for the treatment of cerebral ischemia/reperfusion injury in vitro and in vivo.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520945859
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Sealing reliability assessment of deep-water oil and nature gas pipeline connector considering thermo-mechanical coupling
    SAGE Publications ; 2022
    In:  Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment Vol. 236, No. 1 ( 2022-02), p. 196-208
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part M: Journal of Engineering for the Maritime Environment, SAGE Publications, Vol. 236, No. 1 ( 2022-02), p. 196-208
    Abstract: The deep-water pipeline connector (DPC) is a key piece of equipment for the connection of multiple facilities located in different positions of the subsea production system. Its sealing reliability affects the safety of the production system directly during oil and gas exploration. Although the reliability assessment methods of the DPC have been investigated, previous studies have mostly been carried out under a single mechanical field. To determine the DPC reliability considering thermo-mechanical coupling, this paper establishes random load models of working pressure and temperature by using the Gaussian function, and the stochastic finite element model of the DPC is constructed to obtain the sealing performance under coupling conditions. A Kriging–Sobol sensitivity analysis method is developed to obtain the main variables influencing the sealing performance for the purpose of decreasing the computational cost of the ordinary sensitivity analysis. A reliability assessment approach based on the cross entropy-importance sampling-Kriging method is introduced to analyze the DPC reliability, and a sealing reliability assessment method of DPC under thermo-mechanical coupling conditions is finally formed. An engineering case is taken to verify the effectiveness of the proposed method. The results show that the reliability analysis accuracy of the proposed method is almost agreed with the Monte Carlo method, but the computational cost can be reduced 85.61%, which indicates that the proposed method provides designers with a fast method with an acceptable computational cost to assess the reliability of the DPC connector under coupling conditions.
    Type of Medium: Online Resource
    ISSN: 1475-0902 , 2041-3084
    URL: Article
    DOI: 10.1177/14750902211018394
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2089895-2
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  • 3
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    Online Resource
    A randomized controlled trial on rehabilitation through caregiver-delivered nurse-organized service programs for disabled stroke patients in rural china (the RECOVER trial): design and rationale
    SAGE Publications ; 2016
    In:  International Journal of Stroke Vol. 11, No. 7 ( 2016-10), p. 823-830
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 11, No. 7 ( 2016-10), p. 823-830
    Abstract: Stroke is the leading cause of death and disability in rural China. For stroke patients residing in resource-limited rural areas, secondary prevention and rehabilitation are largely unavailable, and where present, are far below evidence-based standards. Aim This study aims to develop and implement a simplified stroke rehabilitation program that utilizes nurses and family caregivers for service delivery, and evaluate its feasibility and effectiveness in rural China. Methods and design This 2-year randomized controlled trial is being conducted in 2–3 county hospitals located in northwest, northeast, and southwest China. Eligible and consenting stroke inpatients (200 in total) have been recruited and randomized into either a control or intervention group. Nurses in the county hospital are trained by rehabilitation specialists and in turn train the family caregivers in the intervention group. They also provide telephone follow-up care three times post discharge. The recruitment, baseline, intervention, follow-up care, and evaluation are guided by the RECOVER mobile phone app specifically designed for this study. Study outcome The primary outcome is patients’ Barthel Index (activities of daily living: mobility, self-care, and toileting) at 6 months. Process and economic evaluation will also be conducted. Discussion The results of our study will generate initial high-quality evidence to improve stroke care in resource-scarce settings. If proven effective, this innovative care delivery model has the potential to improve the health and function of stroke patients, relieve caregiver burden, guide policy-making, and advance translational research in the field of stroke care.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493016654290
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2211666-7
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