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  • SAGE Publications  (65)
  • English  (65)
  • 1
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    Serum carbohydrate antigen 125 levels and incident risk of type 2 diabetes mellitus in middle-aged and elderly Chinese population: The Dongfeng–Tongji cohort study
    SAGE Publications ; 2019
    In:  Diabetes and Vascular Disease Research Vol. 16, No. 5 ( 2019-09), p. 424-430
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 16, No. 5 ( 2019-09), p. 424-430
    Abstract: The aim of this study was to investigate the association between serum carbohydrate antigen 125 concentrations and incident type 2 diabetes mellitus risk in a prospective cohort. Methods: We included 18,983 eligible participants aged 63.1 years derived from the Dongfeng–Tongji cohort at baseline from September 2008 to June 2010, and they were followed until October 2013. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence interval of type 2 diabetes mellitus incidence in relation to carbohydrate antigen 125 concentrations. Results: In all, 1594 incident cases of type 2 diabetes mellitus were observed after a median follow-up of 4.6 years. Carbohydrate antigen 125 concentrations were categorized into four groups according to the quartiles of distribution: 〈 1.1, 1.1–5.6, 5.6–10.0 and ⩾10 U/mL. Compared with participants in the lowest quartile, the hazard ratio (95% confidence interval) of type 2 diabetes mellitus was 0.97 (0.81–1.15), 1.23 (1.05–1.45) and 1.48 (1.27–1.74) for quartile 2–quartile 4 of carbohydrate antigen 125 concentrations after adjustment for potential confounders ( p for trend  〈  0.001). With per–standard deviation increase in carbohydrate antigen 125 levels, the hazard ratio of type 2 diabetes mellitus increased 12% (95% confidence interval, 8–16). Conclusion: Findings from this study indicated that serum carbohydrate antigen 125 concentrations were positively correlated with incident type 2 diabetes mellitus risk among a middle-aged and elderly Chinese population.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164119843095
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2250797-8
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  • 2
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    Correlation analysis between JAK2 , MPL , and CALR mutations in patients with myeloproliferative neoplasms of Chinese Uygur and Han nationality and their clinical characteristics
    SAGE Publications ; 2018
    In:  Journal of International Medical Research Vol. 46, No. 11 ( 2018-11), p. 4650-4659
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 46, No. 11 ( 2018-11), p. 4650-4659
    Abstract: Genetic factors play a role in the etiology of BCR-ABL-negative myeloproliferative neoplasms (MPNs). This study explored the relationship between mutations in the Janus kinase 2 gene ( JAK2), MPL, and the calreticulin gene ( CALR) in Uygur and Han Chinese patients with BCR-ABL fusion gene-negative MPN and corresponding clinical features. Methods A total of 492 BCR-ABL-negative MPN patients treated in our hospital from May 2013 to August 2016 were enrolled. Genomic DNA was extracted from peripheral blood and used for PCR amplification and DNA sequencing. Mutations including JAK2 V617F, MPL W515L/K, and those in JAK2 exon 12 and CALR were analyzed and compared with patient clinical characteristics. Results Of the 492 MPN patients, 169 were Uygur and 323 were Han. In these two patient groups, JAK2 mutations were detected in 39.64% and 52.63%, respectively, CALR mutations were detected in 10.06% and 20.43%, respectively, and MPL mutations were detected in 0.93% of Han patients. The age, white blood cell count, platelet levels, and hemoglobin levels in JAK2 in Han patients were higher than those in Uygur patients. Conclusion Han MPN patients harboring JAK2 mutations had higher level of age, WBC, PLT, and Hb than Uyghur patients with the same mutations.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060518787719
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2082422-1
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  • 3
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    Study on foot-type classification for young adults based on static and dynamic plantar pressure distribution
    SAGE Publications ; 2022
    In:  Advances in Mechanical Engineering Vol. 14, No. 5 ( 2022-05), p. 168781322210979-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 14, No. 5 ( 2022-05), p. 168781322210979-
    Abstract: The application of an effective and reliable foot type classification method is very important for foot type judgment, injury risk assessment, and correction. Therefore, this paper mainly aims to propose a new foot type classification method for young people based on bitmap index (BI), compare it with the traditional footprint classification method, and put forward and analyze the factors affecting foot type classification. Thirty-one healthy volunteers were asked to perform two types tests in order to study the plantar pressure distribution with static and dynamic conditions, the first type is footprint test with full load of static, and the other type is plantar pressure distribution, which contains four different tests: no load, half load, and full load of static state, as well as dynamic plantar pressure distribution during process of walking. The Intraclass Correlation Coefficient results (ICC) were good reliable and reproducible for BI value with dynamic test (DT-BI value 0.738, 95% confidence interval [0.535, 0.848], [Formula: see text] ) and full-load (FL-BI value 0.725 [0.281, 0.814], [Formula: see text] , p  〈  0.001), obtained with individual measures and a two-way mixed-effects model. It can be seen from Kappa coefficient and density map that DT-BI has high classification accuracy. Classification of foot type based on bitmap index values showed good reliability in people with varying BMI, which can help clinicians and researchers segment the sample population to better distinguish between different foot types of activity, gait or treatment effects.
    Type of Medium: Online Resource
    ISSN: 1687-8132 , 1687-8140
    URL: Article
    DOI: 10.1177/16878132221097904
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2501620-9
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  • 4
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    Dynamic recrystallization of Ti-6Al-4V titanium alloy based on cellular automata
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 237, No. 4 ( 2023-08), p. 1442-1459
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 237, No. 4 ( 2023-08), p. 1442-1459
    Abstract: Ti-6Al-4V (TC4) alloy is a (α + β) two-phase titanium alloy and has good process plasticity, superplasticity, and corrosion resistance. It is widely used in the aerospace industry. During the hot working process, the microstructure and deformation behavior affect its mechanical properties. However, most of the current research focuses on the use of metallographic methods and physical modeling methods to characterize and estimate the evolution of microstructures and lacks accuracy. Therefore, in this study, the thermal deformation behavior of TC4 titanium alloy is predicted and the dynamic recrystallization process is visualized through thermal simulation test, metallographic test, particle swarm optimization–backpropagation (PSO–BP) algorithm, and cellular automata (CA) method. The conclusions are as follows: the grain growth of TC4 titanium alloy is relatively uneven during hot compression. The increase in temperature and the decrease in strain rate are favorable to dynamic recrystallization. After hot compression, the grain texture appeared in the microstructure of TC4 titanium alloy, and the type and strength of texture changed with the change in temperature. Based on the PSO–BP algorithm, the rheological behavior of TC4 titanium alloy during hot compression is predicted. Compared with the experimental value, the correlation of the PSO–BP model is 0.9972, and the error is within 10%. Finally, using the PSO–BP algorithm as the input, combined with the CA method and the related theory of dynamic recrystallization, the dynamic recrystallization behavior of TC4 titanium alloy during hot compression is simulated. The electron backscatter diffraction test is used for comparison, and the simulated microstructure is similar to the experimental structure after removing the influence of some defects. The average grain size error is within 10%. It shows that this model can well predict the dynamic recrystallization behavior of TC4 titanium alloy during hot compression.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/09544089221125575
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2024897-0
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  • 5
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    The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study
    SAGE Publications ; 2021
    In:  Therapeutic Advances in Respiratory Disease Vol. 15 ( 2021-01), p. 175346662110497-
    Details
    In: Therapeutic Advances in Respiratory Disease, SAGE Publications, Vol. 15 ( 2021-01), p. 175346662110497-
    Abstract: The aim of this study was to investigate the predictive role of lymphocyte subsets and other laboratory measurements in patients with COVID-19. Methods: Electronic medical records of adult patients with confirmed diagnosis of COVID-19 from the Shanghai Public Health Clinical Center were reviewed retrospectively to obtain relevant data. Results: The mean age of patients was 40.98 ± 15.95 years, with 58% of the patients being males. The cutoff values at the intensive care unit (ICU) admission, mechanical ventilation, and mortality were CD4+ cells (267, 198, and 405), CD8+ cells (263, 203, and 182), and CD4+ /CD8+ cells (1.4, 1.8, and 1.4). The cutoffs below these values indicate the higher chances of disease progression. Higher CD4+ cell count led to lesser chances for ICU admission [odds ratio (OR) (95% confidence interval (CI): 0.994 (0.991, 0.997); p = 0.0002] and mortality [OR (95% CI): 0.988 (0.979, 0.99); p = 0.001] , higher CD8+ count was an independent risk factor for ICU admission. T-cell count positively correlated with total lymphocyte count and platelets, while negatively correlated with D-dimer and lactate dehydrogenase (LDH). Among patients with non-severe COVID-19, median CD8+ T cell, CD4+ T cell, total lymphocyte count, and platelets were 570, 362, 1.45, and 211, respectively, while median values decreased to 149, 106, 0.64, and 172, respectively, in patients with severe COVID-19. Conclusion: Lower T lymphocyte subsets were significantly associated with higher admission to ICU, mechanical ventilation, and mortality among patients with COVID-19. A cutoff value of ICU admission, mechanical ventilation, and mortality below CD4+ cells (267, 198, and 405), CD8+ cells (263, 203, 182), and CD4+/CD8+ cells (1.4, 1.8, 1.4) may help identify patients at high risk of disease progression. The continuous evaluation of laboratory indices may help with dismal prognosis and prompt intervention to improve outcomes.
    Type of Medium: Online Resource
    ISSN: 1753-4666 , 1753-4666
    URL: Article
    DOI: 10.1177/17534666211049739
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2387506-9
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  • 6
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    Effects of Acupuncture and Moxibustion on Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    SAGE Publications ; 2021
    In:  Integrative Cancer Therapies Vol. 20 ( 2021-01), p. 153473542110441-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 20 ( 2021-01), p. 153473542110441-
    Abstract: The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to evaluate the effects of acupuncture and moxibustion (AM) in women with breast cancer-related lymphedema (BCRL). Methods: We retrieved RCTs published before January 24, 2021, from the MEDLINE, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (VIP), and Wanfang databases. RCTs that compared acupuncture and/or moxibustion intervention with other treatments were included. A random effects or fixed effects model was used based on the heterogeneity findings. Study quality was evaluated using the Cochrane risk of bias tool. Results: We included 14 RCTs in the analyses, of which 4 RCTs adopted acupuncture, 4 RCTs used moxibustion, and the rest used both. AM significantly reduced arm circumference at the elbow crease compared to routine care (Mean deviation (MD) = −7.26, 95% confidence interval (CI) = −8.30 to −6.21, P  〈  .00001). There was a significant difference between AM and diosmin tablets in the effective index for upper limb lymphedema (MD = 24.68, 95% CI = 24.82-30.53, P  〈  .00001), the range of motion of the shoulder during protraction (MD = 6.77, 95% CI = 2.81-10.73, P = .0008), and adduction (MD = 4.17, 95% CI = 1.02-7.32, P = .01). There was a significant difference between moxibustion and pneumatic circulation (MD = −0.51, 95% CI = −0.85 to −0.17, P = .003) in the visual analog score (VAS) for swelling. Finally, compared to the blank control, acupuncture reduced the VAS for pain (MD = −1.33, 95% CI = −1.52 to −1.15, P  〈  .00001; heterogeneity ( I 2 ) = 0%, P = .57). Conclusion: Our results suggest that AM is effective in the treatment of BCRL. AM may reduce arm circumference at the elbow crease (compared to routine care), increase effective index for upper limb lymphedema (compared to oral diosmin tablets), improve the range of motion of the shoulder during protraction and adduction (compared to oral diosmin tablets), and decrease the VAS for both swelling (compared to pneumatic circulation) and pain (compared to blank control).
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/15347354211044107
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2101248-9
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  • 7
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    Experimental and numerical study on attenuation of thermal radiation from large-scale pool fires by water mist curtain
    SAGE Publications ; 2015
    In:  Journal of Fire Sciences Vol. 33, No. 4 ( 2015-07), p. 269-289
    Details
    In: Journal of Fire Sciences, SAGE Publications, Vol. 33, No. 4 ( 2015-07), p. 269-289
    Abstract: Full-scale experiments and numerical simulations were conducted to study the thermal radiation attenuation from large fires by water mist curtain with low and intermediate pressures. Fire dynamics simulator (version 6) was used for numerical simulations. A novel multi-injector nozzle was designed to generate a homogeneous water mist curtain with low water consumption. Water mist characteristics of one of the injectors were measured by Shadowgraphy technology. A 1 × 1 m diesel pool fire was considered as the fire source. The experimental results show that the water mist curtain has high thermal radiation attenuation efficiency, for example, about 82.7% radiant heat flux could be attenuated by the water mist curtain with 2 MPa working pressure and flow rate of 13.3 L/min. Comparisons with the experimental results show that the calculated radiant heat flux and temperature are slightly underestimated.
    Type of Medium: Online Resource
    ISSN: 0734-9041 , 1530-8049
    URL: Article
    DOI: 10.1177/0734904115585796
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2088221-X
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  • 8
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    Nurse researchers’ perspectives on research ethics in China
    SAGE Publications ; 2019
    In:  Nursing Ethics Vol. 26, No. 3 ( 2019-05), p. 798-808
    Details
    In: Nursing Ethics, SAGE Publications, Vol. 26, No. 3 ( 2019-05), p. 798-808
    Abstract: In China, research ethics is a subject of increasingly formal regulation. However, little is known about how nursing researchers understand the concept of research ethics and the ways in which they can maintain ethical standards in their work. Aim: The aim of this study is to examine nursing researchers’ perspectives on research ethics in China. Research design: We conducted a descriptive qualitative study. Qualitative research methods enabled us to gain an in-depth understanding of nursing researchers’ views on research ethics. Participants and research context: We carefully selected and extensively interviewed 28 nursing researchers, nursing faculty, and clinical nurses who had been involved in research or who may undertake research in the future. We collected data between October 2014 and March 2015. Ethical considerations: This study was approved by the institutional review boards of Yale University and Central South University. Findings: We grouped the data into five categories based on the interviewees’ responses: (1) perceptions of ethics, bioethics, and research ethics; (2) perception of the ethics review process; (3) perception of the function of institutional review boards; (4) the need for comprehensive ethical guidelines for future studies; and (5) ethical challenges faced by the interviewees. Discussion and conclusion: This study contributes new insights into nursing researchers’ views on research ethics in China and finds considerable shortcomings in researchers’ understanding and implementation of ethical principles. Intensive educational efforts are needed to provide nursing researchers, institutional review board members, and even study subjects with accurate and up-to-date information and guidance on research ethics. In addition, while Western research ethics theoretically have guided Chinese clinical research for several years, the ways in which nursing researchers have implemented these ethical standards highlight the differences between the Eastern and Western ethical paradigms. This finding suggests the need for ethical standards that are more tailored to the Chinese context.
    Type of Medium: Online Resource
    ISSN: 0969-7330 , 1477-0989
    URL: Article
    DOI: 10.1177/0969733017720848
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2031461-9
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  • 9
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    Effects of 3-Methyladenine on Microglia Autophagy and Neuronal Apoptosis After Radiation-Induced Brain Injury
    SAGE Publications ; 2022
    In:  Dose-Response Vol. 20, No. 2 ( 2022-04), p. 155932582211005-
    Details
    In: Dose-Response, SAGE Publications, Vol. 20, No. 2 ( 2022-04), p. 155932582211005-
    Abstract: To determine the effect of the autophagy inhibitor, 3-methyladenine (3-MA), on cognitive function changes, microglia activity, neuronal apoptosis, and inflammation in rats following radiation-induced brain injury. Methods The following groups were established: control, model, and 3-MA. A rat model of radiation-induced brain injury was generated with a medium dose of X-rays. A Morris water maze was used to observe the cognitive function of the rats. H & E staining was used to observe the pathological changes in the hippocampus. The morphological and quantitative changes of neuronal nuclear (NeuN)-positive neurons and Iba-1-positive microglia in the ipsilateral hippocampus were analyzed by immunohistochemistry. Western blot analysis was done to measure the changes of NeuN ionized calcium binding adapter molecule 1(Iba-1) and apoptosis-related proteins. Immunofluorescence staining of Iba-1 and Microtuble-associated protein light chain 3 (LC3) was done to evaluate the changes in microglia autophagy. TUNEL staining was used to detect apoptosis in the hippocampus. Enzyme-Linked Immunosorbent Assay was used to detect the levels of TNF-α and IL-6 as a measure of the inflammatory response in the hippocampus. Results After irradiation, the nucleus of the neurons in the hippocampus was constricted, the pyramidal tract structure was disordered, neuronal apoptosis was increased ( P 〈 .001), the expression of microglia increased ( P 〈 .01), autophagy was increased ( P 〈 .05), and conversion of microglia to the M2 type increased ( P 〈 .05). After 3-MA administration, the level of autophagy decreased ( P 〈 .05), the damage to the hippocampal region was reduced, neuronal apoptosis decreased ( P 〈 .01), and the activity of the microglia decreased ( P 〈 .01). Conclusion Radiation can active the Microglia. 3-MA inhibits autophagy and excessive activity in microglia, and promotes the conversion of microglia from the M1 to the M2 type, thereby promoting the recovery of brain tissue following radiation exposure.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/15593258221100593
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2440820-7
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  • 10
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    High antibacterial and antioxidant cotton fabric based on AgNPs@HTCS and hyaluronic acid via lay by lay self-assembly
    SAGE Publications ; 2022
    In:  Journal of Industrial Textiles Vol. 52 ( 2022-08), p. 152808372211409-
    Details
    In: Journal of Industrial Textiles, SAGE Publications, Vol. 52 ( 2022-08), p. 152808372211409-
    Abstract: The fabrics of health care function have drawn increasing attention. Herein, AgNO 3 was in-situ reduced into nano silver (AgNPs) by aloe extract (AVE) as reducing agent to gain AgNPs@hinokitiol-grafted chitosan (AgNPs@HTCS). The antibacterial and antioxidant cotton fabric were fabricated by LBL method using AgNPs@HTCS as positive layer and hyaluronic acid as negative layer. The results showed that the optimum preparation conditions of AgNPs@HTCS were as follows: AgNO 3 10 mmol/L, HTCS 40 v/v %, AVE 15 mL, 80 °C, 6 h. MIC values of AgNPs@HTCS against S. aureus and E. coli attained 1.7 μg/mL and 5.3 μg/mL, respectively. The antibacterial ratio of cotton fabric reached the maximum 99.9 % at very low concentration of AgNPs@HTCS 0.25 g/L. After 3 LBL layers, the antibacterial properties of functional cotton fabric could withstand the acid or alkali washing. After 25 washing cycles, the antibacterial rate of LBL fabric still maintained above 96 %. Compared with the untreated fabric, antioxidant capacity of LBL functional cotton fabric raised approximately two times. LBL functional cotton fabric still retained the wear performances of the original fabric.
    Type of Medium: Online Resource
    ISSN: 1528-0837 , 1530-8057
    URL: Article
    DOI: 10.1177/15280837221140922
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2095351-3
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