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  • 1
    Online Resource
    Online Resource
    Highly precise navigation at the lateral skull base by the combination of flat-panel volume CT and electromagnetic navigation
    SAGE Publications ; 2021
    In:  Science Progress Vol. 104, No. 3 ( 2021-07), p. 003685042110320-
    Details
    In: Science Progress, SAGE Publications, Vol. 104, No. 3 ( 2021-07), p. 003685042110320-
    Abstract: This study aimed to evaluate the feasibility and accuracy of electromagnetic navigation at the lateral skull base in combination with flat panel volume computed tomography (fpVCT) datasets. A mastoidectomy and a posterior tympanotomy were performed on 10 samples of fresh frozen temporal bones. For registration, four self-drilling titanium screws were applied as fiducial markers. Multi-slice computed tomography (MSCT; 600 µm), conventional flat panel volume computed tomography (fpVCT; 466 µm), micro-fpVCT (197 µm) and secondary reconstructed fpVCT (100 µM) scans were performed and data were loaded into the navigation system. The resulting fiducial registration error (FRE) was analysed, and control of the navigation accuracy was performed. The registration process was very quick and reliable with the screws as fiducials. Compared to using the MSCT data, the micro-fpVCT data led to significantly lower FRE values, whereas conventional fpVCT and secondary reconstructed fpVCT data had no advantage in terms of accuracy. For all imaging modalities, there was no relevant visual deviation when targeting defined anatomical points with a navigation probe. fpVCT data are very well suited for electromagnetic navigation at the lateral skull base. The use of titanium screws as fiducial markers turned out to be ideal for comparing different imaging methods. A further evaluation of this approach by a clinical trial is required.
    Type of Medium: Online Resource
    ISSN: 0036-8504 , 2047-7163
    URL: Article
    DOI: 10.1177/00368504211032090
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Nasotracheal Airway-Oropharyngeal Alimentary Canal: A Microvascular Technique for Reconstruction of the Upper Airway after Total Laryngectomy
    SAGE Publications ; 1995
    In:  Annals of Otology, Rhinology & Laryngology Vol. 104, No. 4 ( 1995-04), p. 317-322
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 104, No. 4 ( 1995-04), p. 317-322
    Abstract: Every patient who has to be laryngectomized because of a carcinoma is concerned with the loss of his or her voice and the presence of a permanent tracheostoma in his or her neck. While various methods for producing a substitute voice are available (esophageal voice, voice devices, voice-shunt operations with or without voice prosthesis), it is usually impossible after laryngectomy to reconstruct a complete upper airway so that the tracheostoma can be closed. One potential method for reconstruction of the airway is its division into a nasotracheal airway and an oropharyngeal alimentary canal. Ten Alsatian dogs were laryngectomized, and a microvascularly anastomosed jejunal autograft was inserted as a junction between the tracheal stump and the circularly exposed nasopharynx, while the pharynx was reconstructed separately. One week postoperatively, oral feeding could be started again; at the same time breathing was possible via the reconstructed nasotracheal airway, which was kept open by insertion of a silicone tube. By means of this microvascular technique, a complete nasal airway could be reconstructed surgically after laryngectomy.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/000348949510400412
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1995
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  • 3
    Online Resource
    Online Resource
    Characterization of T-cell Subpopulations in Patients with Chronic Rhinosinusitis with Nasal Polyposis
    SAGE Publications ; 2017
    In:  Allergy & Rhinology Vol. 8, No. 3 ( 2017-01), p. ar.2017.8.0214-
    Details
    In: Allergy & Rhinology, SAGE Publications, Vol. 8, No. 3 ( 2017-01), p. ar.2017.8.0214-
    Abstract: There is an ongoing discussion concerning the potential origins of chronic rhinosinusitis with nasal polyposis (CRSwNP). Objective The aim of this study was to quantify subpopulations of T cells in peripheral blood and nasal polyps in CRSwNP to examine their influence on the etiology of this disease. Methods Tissue and blood samples were collected from 11 patients who underwent nasal sinus surgery, and these samples were analyzed by multicolor flow cytometry. Results There was a significantly lower frequency of CD4 + T-helper (Th) cells and a significantly higher frequency of CD8 + T cells among lymphocytes isolated from nasal polyps compared with peripheral blood mononuclear cells (PBMC). In both T-cell subpopulations, a shift mainly from naive T cells among peripheral blood lymphocytes toward an effector memory and terminally differentiated subtype predominance in nasal polyps was observed. Among CD4 + T cells, the frequencies of cluster of differentiation (CD) 45RA- Forkhead-Box-Protein P3high (FoxP3 high ) cytotoxic T-lymphocyte-associated Protein 4 high (CTLA-4 high ) activated regulatory T (T reg ) cells, and CD45RA- Forkhead-Box-Protein P3low (FoxP3 low ) memory T cells were significantly increased in nasal polyps compared with PBMC. Conclusion In this study, we presented a detailed characterization of CD4 + and CD8 + T-cell subpopulations in patients with CRSwNP. CD8 + T cells were more prominent in nasal polyps than in CD4 + T cells. Both nasal CD8 + T cells and CD4 + T cells predominantly had an effector memory phenotype. Among CD4 + T cells, activated T reg cells were increased in nasal polyps compared with PBMC. The data point toward a local regulation of T-cell composition within the microenvironment of nasal polyps, which might be further exploited in the future to develop novel immunotherapeutic strategies.
    Type of Medium: Online Resource
    ISSN: 2152-6567 , 2152-6567
    URL: Article
    DOI: 10.2500/ar.2017.8.0214
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
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  • 4
    Online Resource
    Online Resource
    Influence of different growth factors on chondrogenic differentiation of adipose-derived stem cells in polyurethane-fibrin composites
    SAGE Publications ; 2012
    In:  The International Journal of Artificial Organs Vol. 35, No. 12 ( 2012), p. 1047-1060
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 35, No. 12 ( 2012), p. 1047-1060
    Type of Medium: Online Resource
    ISSN: 0391-3988
    URL: Article
    DOI: 10.5301/ijao.5000132
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
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  • 5
    Online Resource
    Online Resource
    Sensorineural Hearing Loss after Otitis Media with Effusion and Subacute Mastoiditis after Viral Infections of the Upper Respiratory Tract: A Comparative Study of Conservative and Surgical Treatment
    SAGE Publications ; 2016
    In:  Ear, Nose & Throat Journal Vol. 95, No. 9 ( 2016-09), p. E18-E27
    Details
    In: Ear, Nose & Throat Journal, SAGE Publications, Vol. 95, No. 9 ( 2016-09), p. E18-E27
    Abstract: Involvement of the middle ear after viral infections of the upper airways may lead to serous otitis media with effusion in the absence of bacterial infection. This can be accompanied by a concomitant shading of the mastoid air cells, which could manifest as a reduced opacity on computed tomography (CT) in the absence of a history of chronic mastoiditis or acute inflammatory signs. This can lead to a subsequent impairment of inner ear function. CT scans reveal an extended pneumatization of the temporal bones in affected patients. Inner ear hearing impairment can probably be attributed to a concomitant labyrinthine reaction—the so-called toxic inner ear lesion. If no remission occurs within 5 days after initial conservative treatment (paracentesis or hemorrheologic infusions), surgical treatment with a mastoidectomy can accelerate hearing restoration. We conducted a retrospective, nonrandomized study of short- and long-term hearing outcomes in patients with a toxic inner ear lesion who had been treated with conservative measures alone (CONS group) or with surgery (SURG group) in a tertiary care referral center. Our study group was made up of 52 consecutively presenting patients (57 ears) who had been seen over a 10-year period; there were 20 patients (21 ears) in the CONS group and 32 patients (36 ears) in the SURG group. Initially, 15 CONS patients (75%) and 18 SURG patients (56%) complained of dizziness or a balance disorder. The initial averaged sensorineural hearing loss (over 0.5, 1.0, 2.0, and 3.0 kHz) was 32.4 ± 15.6 dB in the CONS group and 35.4 ± 12.0 dB in the SURG group. At follow-up (mean: 31.7 mo), the SURG group experienced a significantly greater improvement in hearing (p = 0.025). We conclude that patients with viral otitis media and concomitant noninflammatory mastoiditis with impairment of inner ear function (sensorineural hearing loss) experience a better hearing outcome when a mastoidectomy is performed during primary treatment.
    Type of Medium: Online Resource
    ISSN: 0145-5613 , 1942-7522
    URL: Article
    DOI: 10.1177/014556131609500908
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2067528-8
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  • 6
    Online Resource
    Online Resource
    Influence of Different Growth Factors on Chondrogenic Differentiation of Adipose-Derived Stem Cells in Polyurethane-Fibrin Composites
    SAGE Publications ; 2012
    In:  The International Journal of Artificial Organs Vol. 35, No. 12 ( 2012-12), p. 1047-1060
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 35, No. 12 ( 2012-12), p. 1047-1060
    Abstract: Chondrogenic differentiation of adipose-derived stem cells (ASCs) has proven to be feasible. To compensate for laryngeal palsy or cartilage defects after surgery or trauma using tissue engineering, a formable and stable scaffold material is mandatory. Methods ASCs were seeded in fibrin-polyurethane scaffolds and cultured in chondrogenic differentiation medium adding the growth factors TGF-□1, TGF-□3, and BMP-2 for up to 35 days. Results Histological examination showed acid glycosaminoglycans in the extracellular matrix in all groups. Immunofluorescence presented positive staining for collagen II, aggrecan, and SOX-9 in the TGF-□1–, TGF-□3–, and BMP-2-group. With Real-time PCR analyses, chondrogenic differentiation became apparent by the expression of the specific genes COL2A1 (collagen II), AGC 1 (aggrecan), and SOX-9, whereas collagen II expression was low in all groups compared to bone marrow-derived stem cells (BMSC) due to reduced chondrogenic ability. Conclusions These findings demonstrate the general ability of ASCs to differentiate into matrix-producing chondrocytes in fibrin-polyurethane scaffolds. However, further experiments are necessary to enhance this chondrogenic potential of ASCs seeded in fibrin-polyurethane scaffolds in order to produce a suitable regeneration method for treating cartilage defects or an implantable medialization material for vocal cord palsy.
    Type of Medium: Online Resource
    ISSN: 0391-3988 , 1724-6040
    URL: Article
    DOI: 10.1177/039139881203501203
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 1474999-3
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  • 7
    Online Resource
    Online Resource
    ERRATUM IN: Influence of different growth factors on chondrogenic differentiation of adipose-derived stem cells in polyurethane-fibrin composites”
    SAGE Publications ; 2013
    In:  The International Journal of Artificial Organs Vol. 36, No. 1 ( 2013), p. 73-73
    Details
    In: The International Journal of Artificial Organs, SAGE Publications, Vol. 36, No. 1 ( 2013), p. 73-73
    Type of Medium: Online Resource
    ISSN: 0391-3988
    URL: Article
    DOI: 10.5301/IJAO.2013.10751
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 1474999-3
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