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  • SAGE Publications  (18)
  • English  (18)
  • 1
    Online Resource
    Online Resource
    Low Doses of Camptothecin Induced Hormetic and Neuroprotective Effects in PC12 Cells
    SAGE Publications ; 2015
    In:  Dose-Response Vol. 13, No. 2 ( 2015-04-01), p. 155932581559260-
    Details
    In: Dose-Response, SAGE Publications, Vol. 13, No. 2 ( 2015-04-01), p. 155932581559260-
    Abstract: Hormetic response is an adaptive mechanism for a cell or organism surviving in an unfavorable environment. It has been an intriguing subject of researches covering a broad range of biological and medical disciplines, in which the underlying significance and molecular mechanisms are under intensive investigation. In the present study, we demonstrated that topoisomerase I inhibitor camptothecin (CPT), a potent anticancer agent, induced an obvious hormetic response in rat pheochromocytoma PC12 cells. Camptothecin inhibited PC12 cell growth at relative high doses as generally acknowledged while stimulated the cell growth by as much as 39% at low doses. Moreover, low doses of CPT protected the cells from hydrogen peroxide (H 2 O 2 )-induced cell death. Phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathways were reported playing pivotal roles in protecting cells from oxidative stress. We observed that these 2 pathways were upregulated by low doses of CPT, as evidenced by increased levels of phosphorylated PI3K, phosphorylated Akt, phosphorylated mammalian target of rapamycin, Nrf2, and HO-1; and abolishment of the growth-promoting and neuroprotective effects of CPT by LY294002, a PI3K inhibitor. These results suggest that the hormetic and neuroprotective effects of CPT at low doses on PC12 cells were attributable, at least partially, to upregulated PI3K/Akt and Nrf2/HO-1 pathways.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325815592606
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2440820-7
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  • 2
    Online Resource
    Online Resource
    Primary central nervous system Hodgkin's lymphoma: a case report
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 4 ( 2021-04), p. 030006052199953-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 4 ( 2021-04), p. 030006052199953-
    Abstract: Primary central nervous system Hodgkin's lymphoma (CNS-HL) is extremely rare. This current case report describes a 60-year-old male patient that presented with numbness of the left lower extremity and worsening headache. After a full range of investigations and a partial resection of the right cerebellum, external ventricular drainage reservoir placement and cranioplasty, he was diagnosed with primary CNS-HL. The patient was treated with 3 g/m 2 methotrexate (intravenous [i.v.], once a day, day 1) and 1 g/m 2 cytarabine (i.v., every 12 h, days 2 + 3), followed by anti-programmed cell death protein 1 antibodies (200 mg sintilimab, i.v., once a day, day 1, every 3 weeks). After six courses of treatment with intrathecal injections of 50 mg cytarabine (once a day, day 1) and 5 mg dexamethasone (once a day, day 1), there was no residual lesion on cranial magnetic resonance imaging. No significant drug-related adverse events were observed. The patient has been followed up every 3 months and no relapse has occurred.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060521999533
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 3
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    Delamination and dissection of arteriovenous grafts: A multicenter report of four cases
    SAGE Publications ; 2022
    In:  The Journal of Vascular Access
    Details
    In: The Journal of Vascular Access, SAGE Publications
    Abstract: Arteriovenous (AV) grafts are an alternative vascular access for chronic hemodialysis. AV graft failure is often due to stenosis of the feeding artery, graft, or draining vein. We report four cases of AV graft dysfunction and failure rarely caused by graft delamination and dissection. Two males and two females aged 47–67 years had been on chronic hemodialysis. Ultrasound examination detected graft delamination and dissection between 1 and 33 months after Acuseal AV graft implantation. Two cases were successfully treated with stenting and partial graft replacement, respectively. False lumen volume reduction by fluid withdrawal failed to salvage the delaminated graft in one of the patients. The delamination and dissection of another case spontaneously resolved 5 months later. Graft delamination and dissection should be considered as a possible cause for AV graft dysfunction and failure. Stenting and graft replacement may be recommended to treat AV graft dissection and delamination.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.1177/11297298221074455
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2079292-X
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  • 4
    Online Resource
    Online Resource
    Clinical characteristics of hemodialysis patients with left brachiocephalic vein obstruction due to extrinsic compression or prior catheterization
    SAGE Publications ; 2023
    In:  The Journal of Vascular Access
    Details
    In: The Journal of Vascular Access, SAGE Publications
    Abstract: Left brachiocephalic vein (LBCV) stenosis is a common complication in hemodialysis patients and is a heterogenous disorder associated with either prior catheterization or extrinsic compression. This study aimed to characterize patients with LBCV stenosis or occlusion with and without a history of central venous catheterization. Methods: We performed a retrospective study in 84 hemodialysis patients with LBCV stenosis or occlusion with ( n = 22) or without ( n = 62) prior catheterization. We compared the clinical features, anatomical factors, restenosis after balloon venoplasty, and patency rates of patients in these two groups. Results: In the cohort of 84 patients with LBCV stenosis or occlusion, 73.8% (62 patients) of them had no history of catheterization. Patients without prior catheterization had more stenotic lesions ( p  〈  0.05) but less occlusive lesions ( p  〈  0.05) than patients with prior catheterization. The space between the sternum and the aorta was narrower in patients without prior catheterization than that in patients with prior catheterization ( p  〈  0.05). Percutaneous venography was performed in 81 patients, and the occurrence of recoil after venoplasty in patients without prior catheterization was significantly higher than that in patients with prior catheterization ( p  〈  0.05). The rate of stent implantation was significantly higher in patients without prior catheterization than patients with prior catheterization ( p  〈  0.05), whereas there was no significant difference in primary patency between the two groups. Conclusions: LBCV stenosis and occlusion are mainly due to extrinsic compression rather than prior central venous catheterization. Stent implantation is frequently required after venoplasty to treat LBCV obstructive lesions in patients without prior catheterization.
    Type of Medium: Online Resource
    ISSN: 1129-7298 , 1724-6032
    URL: Article
    DOI: 10.1177/11297298231184649
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2079292-X
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  • 5
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    Online Resource
    Extracellular ATP is a potent signaling molecule in the activation of the Japanese flounder ( Paralichthys olivaceus ) innate immune responses
    SAGE Publications ; 2020
    In:  Innate Immunity Vol. 26, No. 5 ( 2020-07), p. 413-423
    Details
    In: Innate Immunity, SAGE Publications, Vol. 26, No. 5 ( 2020-07), p. 413-423
    Abstract: Innate immunity is the first line of defense against pathogen infections. Extracellular ATP (eATP) is one of the most studied danger-associated molecular pattern molecules that can activate host innate immune responses through binding with and activating purinergic receptors on the plasma membrane. The detailed actions of eATP on fish innate immunity, however, remain poorly understood. In this study, we investigated bacterial pathogen-induced ATP release in head kidney cells of the Japanese flounder Paralichthys olivaceus. We also examined the actions of eATP on pro-inflammatory cytokine and immune-related gene expression, the activity of induced NO synthase (iNOS), and the production of reactive oxygen species (ROS) and NO in Japanese flounder immune cells. We demonstrate that ATP is dynamically released from Japanese flounder head kidney cells into the extracellular milieu during immune challenge by formalin-inactivated Edwardsiella tarda and Vibrio anguillarum. In addition, we show that eATP administration results in profound up-regulation of pro-inflammatory cytokine gene expression, iNOS activity, and inflammatory mediator production, including ROS and NO, in Japanese flounder immune cells. Altogether, our findings demonstrate that eATP is a potent signaling molecule for the activation of innate immune responses in fish.
    Type of Medium: Online Resource
    ISSN: 1753-4259 , 1753-4267
    URL: Article
    DOI: 10.1177/1753425918804635
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2381250-3
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  • 6
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    The novel hybrid polycarbonate polyurethane / polyester three-layered large-diameter artificial blood vessel
    SAGE Publications ; 2022
    In:  Journal of Biomaterials Applications Vol. 36, No. 6 ( 2022-01), p. 965-975
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 36, No. 6 ( 2022-01), p. 965-975
    Abstract: The most common materials of artificial blood vessels are polyethylene terephthalate and polytetrafluoroethylene. But polycarbonate polyurethane (PCU) is an ideal material for vascular prostheses because of their excellent characteristics. As far as we know, our artificial blood vessel is the first type of hybrid PCU/polyester three-layered large-diameter artificial blood vessel in the world. Objective The purpose of this preclinical animal experiment is to evaluate the hemocompatibility, histocompatibility, effectiveness, and safety of the three-layered large-diameter artificial blood vessel in sheep. Methods The artificial blood vessels took place of the initial segments of the sheep’s thoracic aorta by end-to-end anastomosis. Results All of the 14 sheep are male, their average body weight (BW) was 30.57 ± 3.95 kg. All 14 artificial blood vessels successfully replaced the thoracic aortas. 5 sheep did not survive to the end of the experiment, while the remaining 9 sheep did. After the surgery, the blood biochemical and blood routine indicators fluctuate slightly within the normal range. The angiography showed that the implanted artificial blood vessels were unobstructed without obvious stenosis or expansion. 24 weeks after surgery, the lumen surfaces of the artificial blood vessels were covered by endothelia in different degrees, and the average endothelialization rate was 69.44% (range: 20% to 100%). Conclusions This artificial blood vessel is the first to use PCU in large-diameter artificial vascular grafts. It has excellent blood compatibility, wonderful biocompatibility, high endothelialization rate, and 100% patency.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/08853282211033415
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 7
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    Variable-stiffness optimization of CFRP body panels for body-in-white
    SAGE Publications ; 2023
    In:  Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering, SAGE Publications
    Abstract: Body panels have a direct influence on the static and dynamic stiffness of the body-in-white. With the introduction of CFRP in automotive body, these panels have ushered in the potential of being designed with variable-stiffness. However, due to the inherent complexity of variable-stiffness design and the need to integrate all panels to account for their interaction on BIW, the related design issue has not been solved. This paper reports a design method to achieve the successive optimization of the thickness distribution and stacking sequence for body panels, as well as ensure basic manufacturing and blending requirements of design results. This method was applied to the virtual design of the roof, floor, outer and inner side panels of a body-in-white. Compared with original constant-stiffness CFRP components, a 16.4% weight reduction was attained, the torsional and bending stiffness, first-order torsional and bending frequencies were enhanced by 5.0%, 10.9%, 4.7%, and 7%, respectively.
    Type of Medium: Online Resource
    ISSN: 0954-4070 , 2041-2991
    URL: Article
    DOI: 10.1177/09544070221147373
    RVK:
    ZO 4200
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2032754-7
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  • 8
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    Patient Satisfaction With Oral vs Intravenous Sedation for Vitrectomy Surgery: A Randomized, Noninferiority Clinical Trial
    SAGE Publications ; 2022
    In:  Journal of VitreoRetinal Diseases Vol. 6, No. 3 ( 2022-05), p. 201-209
    Details
    In: Journal of VitreoRetinal Diseases, SAGE Publications, Vol. 6, No. 3 ( 2022-05), p. 201-209
    Abstract: This work aims to determine whether patient satisfaction with oral sedation is noninferior to intravenous (IV) sedation in vitrectomy surgery. Methods: This prospective, randomized, double-masked, noninferiority clinical trial measured patient satisfaction in 84 participants receiving oral or IV sedation during vitrectomy surgery under monitored anesthesia care. Patients were excluded if they were unable to receive benzodiazepines. Results: The primary outcome was patient satisfaction. Secondary outcomes included surgeon and anesthesia provider satisfaction, need for supplemental anesthesia, and surgical complications. Among the 84 patients (46 [54.8%] men; mean [SD] age, 57.0 [12.7 years]), mean patient satisfaction scores were 5.22 ± 0.81 (range, 3.08-6; scale 1-6) with oral and 5.25 ± 0.63 (range, 3.83-6; scale 1-6) with IV sedation. With an a priori noninferiority margin of 0.5 and a difference in mean scores between the groups of 0.03 (1-tailed 95% CI, infinity to 0.29), our results demonstrated the noninferiority of oral sedation ( P = .002). There were no significant differences in surgeon or anesthesia satisfaction or major intraoperative complications. Five patients receiving oral (11.9%) and 3 receiving IV (7.1%) sedation required supplemental IV sedation (difference, 4.8%; P = .46). Conclusions: Patient satisfaction for oral sedation was noninferior to IV sedation for vitrectomy surgery.
    Type of Medium: Online Resource
    ISSN: 2474-1264 , 2474-1272
    URL: Article
    DOI: 10.1177/24741264211027820
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2898183-2
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  • 9
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    Visualizing green space accessibility for more than 4,000 cities across the globe
    SAGE Publications ; 2022
    In:  Environment and Planning B: Urban Analytics and City Science Vol. 49, No. 5 ( 2022-06), p. 1578-1581
    Details
    In: Environment and Planning B: Urban Analytics and City Science, SAGE Publications, Vol. 49, No. 5 ( 2022-06), p. 1578-1581
    Abstract: Green space accessibility has benefits for promoting physical and mental health of urban residents. Many studies have investigated this measure but used limited cities. To fill this gap, this study visualizes green space accessibility for 4353 cities across the globe. Three global open datasets and two different scales (city- and national-scales) were involved for the analysis. We found that most countries and cities have a relative high value in terms of the green space accessibility, and those with a relatively low value are mostly located in South American, African, and Asian countries and cities. The results may be useful not only for local governments to implement precise planning for reducing potential inequality in access to green space, but also for researchers to further investigate the relationship between green space accessibility and various issues related to urban built-up environment.
    Type of Medium: Online Resource
    ISSN: 2399-8083 , 2399-8091
    URL: Article
    DOI: 10.1177/23998083221097110
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2879402-3
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  • 10
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    Sulfonated poly(ether ether ketone)/poly(vinylidene fluoride)/tungstophosphoric acid membrane for vanadium redox flow battery application
    SAGE Publications ; 2016
    In:  High Performance Polymers Vol. 28, No. 6 ( 2016-08), p. 735-740
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 28, No. 6 ( 2016-08), p. 735-740
    Abstract: A blend membrane consisting of sulfonated poly(ether ether ketone), poly(vinylidene fluoride), and tungstophosphoric acid (denoted as SPEEK/PVDF/TPA membrane) has been fabricated and firstly used as ion exchange membrane for vanadium (V) redox flow battery (VRB) application. This composite membrane is characterized by physical and electrochemical methods. The results show that the SPEEK/PVDF/TPA membrane possesses significantly high ion selectivity and low permeability of V(IV) compared with the Nafion 117 membrane. Also VRB single cells with SPEEK/PVDF/TPA membrane show significantly lower capacity loss, higher coulombic efficiency (CE 〉 93%) and higher energy efficiency (EE 〉 80%) than that with Nafion 117 membrane. In the self-discharge test, the cells with the SPEEK/PVDF/TPA membrane show better durability. With all the good properties and low cost, the SPEEK/PVDF/TPA membrane shows promising prospects for application in VRB.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008315596587
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1483713-4
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