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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 231, No. 4 ( 2017-03), p. 713-727
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 231, No. 4 ( 2017-03), p. 713-727
    Abstract: Balloon-borne astronomy offers an attractive option for experiments that require precise pointing and attitude stabilization, due to a large reduction in the atmospheric interference observed by ground-based systems as well as the low-cost and short development time-scale compared to space-borne systems. The Balloon-borne Imaging Testbed (BIT) is an instrument designed to meet the technological requirements of high-precision astronomical missions, and is a precursor to the development of a facility-class instrument with capabilities similar to the Hubble Space Telescope. The attitude determination and control systems (ADCS) for BIT, the design, implementation, and analysis of which are the focus of this paper, compensate for compound pendulation effects and other sub-orbital disturbances in the stratosphere to within 1–2′′ (rms), while back-end optics provide further image stabilization down to 0.05′′ (not discussed here). During the inaugural test flight from Timmins, Canada in September 2015, BIT ADCS pointing and stabilization performed exceptionally, with coarse pointing and target acquisition to within 〈 0.1° and fine stabilization to 0.68′′ (rms) over long (10–30 min) integrations. This level of performance was maintained during flight for several tracking runs that demonstrated pointing stability on the sky for more than an hour at a time. To refurbish and improve the system for the three-month flight from New Zealand in 2018, certain modifications to the ADCS need to be made to smooth pointing mode transitions and to correct for internal biases observed during the test flight. Furthermore, the level of autonomy must be increased for future missions to improve system reliability and robustness.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2032759-6
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 1998
    In:  Journal of Histochemistry & Cytochemistry Vol. 46, No. 3 ( 1998-03), p. 335-343
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 46, No. 3 ( 1998-03), p. 335-343
    Abstract: Intracellular localization of specific mRNAs is known to be a mechanism for targeting proteins to specific sites within the cell. Previous studies from this laboratory have demonstrated co-localization of mRNAs and proteins for a number of genes in absorptive enterocytes of fetal rat intestine. The present study was undertaken to examine in human enterocytes the intracellular localization patterns of mRNAs for the microvillous membrane proteins lactase–phlorizin hydrolase (LPH), sucrase-isomaltase (SI), and intestinal alkaline phosphatase (IAP), and the cytoskeletal protein β-actin. In sections of human jejunum, mRNAs were localized by in situ hybridization using digoxigenin-labeled anti-sense RNA probes. Both LPH and SI mRNAs were localized to the apical region of villous enterocytes, whereas IAP and β-actin mRNAs were detected both apically and basally relative to the nucleus. Therefore, in contrast to LPH, SI, and β-actin mRNAs, which co-localize with their encoded proteins, that of IAP is present in the basal region of the cell where IAP protein has not directly been demonstrated to be present. Absorptive enterocytes from humans possess the mechanisms for intracellular mRNA localization, but not all mRNAs co-localize with their encoded proteins.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 3
    In: The American Surgeon, SAGE Publications, Vol. 88, No. 5 ( 2022-05), p. 953-958
    Abstract: The American Association for the Surgery of Trauma (AAST) has developed a grading system for emergency general surgery (EGS) conditions. We sought to validate the AAST EGS grades for patients undergoing urgent/emergent colorectal resection. Methods Patients enrolled in the “Eastern Association for the Surgery of Trauma Multicenter Colorectal Resection in EGS—to anastomose or not to anastomose” study undergoing urgent/emergent surgery for obstruction, ischemia, or diverticulitis were included. Baseline demographics, comorbidity severity as defined by Charlson comorbidity index (CCI), procedure type, and AAST grade were prospectively collected. Outcomes included length of stay (LOS) in-hospital mortality, and surgical complications (superficial/deep/organ-space surgical site infection, anastomotic leak, stoma complication, fascial dehiscence, and need for further intervention). Multivariable logistic regression models were used to describe outcomes and risk factors for surgical complication or mortality. Results There were 367 patients, with a mean (± SD) age of 62 ± 15 years. 39% were women. The median interquartile range (IQR) CCI was 4 (2-6). Overall, the pathologies encompassed the following AAST EGS grades: I (17, 5%), II (54, 15%), III (115, 31%), IV (95, 26%), and V (86, 23%). Management included laparoscopic (24, 7%), open (319, 87%), and laparoscopy converted to laparotomy (24, 6%). Higher AAST grade was associated with laparotomy ( P = .01). The median LOS was 13 days (8-22). At least 1 surgical complication occurred in 33% of patients and the mortality rate was 14%. Development of at least 1 surgical complication, need for unplanned intervention, mortality, and increased LOS were associated with increasing AAST severity grade. On multivariable analysis, factors predictive of in-hospital mortality included AAST organ grade, CCI, and preoperative vasopressor use (odds ratio (OR) 1.9, 1.6, 3.1, respectively). The American Association for the Surgery of Trauma emergency general surgery grade was also associated with the development of at least 1 surgical complication (OR 2.5), while CCI, preoperative vasopressor use, respiratory failure, and pneumoperitoneum were not. Conclusion The American Association for the Surgery of Trauma emergency general surgery grading systems display construct validity for mortality and surgical complications after urgent/emergent colorectal resection. These results support incorporation of AAST EGS grades for quality benchmarking and surgical outcomes research.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
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  • 4
    In: Child Maltreatment, SAGE Publications, Vol. 15, No. 1 ( 2010-02), p. 48-63
    Abstract: This study examines the prevalence and correlates of heightened posttraumatic stress (PTS) symptoms in a nationally representative sample of 1,848 children and adolescents (ages 8-14) who were referred to child welfare for investigation of abuse or neglect based on the National Survey of Child and Adolescent Well-Being. The severity of current PTS symptoms was assessed using the PTS subscale of the Trauma Symptom Checklist for Children, a standardized child-report scale evaluating common symptoms associated with trauma. The overall prevalence of clinically significant PTS symptoms was 11.7% (overall mean T score = 49.5). The prevalence was higher for cases that were placed in out-of-home care (19.2%) than those maintained at home (10.7%). Multivariate hierarchical regression identified four contributors to heightened PTS symptoms: younger child age, abuse by a nonbiological parent, violence in the home, and child depression. The authors discuss the modest but still lower than expected prevalence of self-reported, clinically significant PTS symptoms and the variables associated with greater risk for heightened PTS symptoms found among cases referred to child welfare services.
    Type of Medium: Online Resource
    ISSN: 1077-5595 , 1552-6119
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 2018206-5
    SSG: 2,1
    SSG: 5,3
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  • 5
    In: Families in Society: The Journal of Contemporary Social Services, SAGE Publications
    Abstract: This study was part of a larger study of Partnering for Success, a federally funded initiative focused on providing evidence-based outpatient mental health treatment to children involved with or at risk for involvement with the child welfare system. With a sample of 782 children, the study explored strategies that therapists can use to reduce racial and ethnic disparities in treatment for behavioral problems in children. The results provide promising evidence that racial and ethnic disparities in treatment receipt for behavioral problems are reduced when therapists administer and adhere to the results of standardized screening instruments and participate in clinical consultation.
    Type of Medium: Online Resource
    ISSN: 1044-3894 , 1945-1350
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2069655-3
    SSG: 3,4
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2017
    In:  Research on Social Work Practice Vol. 27, No. 3 ( 2017-05), p. 283-290
    In: Research on Social Work Practice, SAGE Publications, Vol. 27, No. 3 ( 2017-05), p. 283-290
    Abstract: The purpose of this study is to examine the correlates of child behavior change over time in a replication of the KEEP intervention. Method: The study sample was drawn from the treatment group of the Maryland replication of KEEP (n=65). Change over time was analyzed using multilevel linear mixed modeling. Results: Parents’ use of positive reinforcement relative to discipline was associated with the rate of child behavior change among program participants; parents with the lowest initial levels of reinforcement reported the greatest decrease in child problem behaviors. Other participant characteristics were not associated with child behavior change during the study period. Conclusions: The results indicate the efficacy of an evidence-based foster parent training program for reducing child problem behaviors and underscore the utility of teaching parents to use more positive responses relative to discipline as a robust path to improved child outcomes.
    Type of Medium: Online Resource
    ISSN: 1049-7315 , 1552-7581
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2057740-0
    SSG: 3,4
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  • 7
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 14 ( 2022-01), p. 175883592211340-
    Abstract: The treatment landscape of metastatic renal cell carcinoma (mRCC) has substantially advanced over the last three decades, whereby data from controlled clinical trials indicate significant improvements regarding patients’ overall survival (OS) in highly selected patient cohorts. The aim of this study is to evaluate the impact of potentially game changing drugs on patients’ outcomes by comparing three different historical mRCC treatment eras. Methods: In all, 914 mRCC patients who were diagnosed between July 1985 and September 2020 were included into this observational study and assigned to three different treatment eras [‘cytokine’, ‘first-generation tyrosine kinase inhibitors (TKIs)’, and ‘modern TKIs/immunotherapy’] based on the EMA approval dates of sunitinib (July 2006) and nivolumab (June 2015) in mRCC treatment. OS was considered the primary study endpoint. Kaplan–Meier analyses, log-rank tests, and uni- and multivariable Cox regression models were performed. Results: OS was significantly longer in patients of the modern TKIs/immunotherapy era (median OS not reached) as compared to the cytokine (2.4 years) and first-generation TKIs era (1.7 years, all p  〈  0.001). Moreover, patients of the modern TKIs/immunotherapy era demonstrated a significantly better prognosis [hazard ratio (HR): 0.41, 95% confidence interval (CI): 0.32–0.55, p  〈  0.001] compared to those of the cytokine era, while no statistically significant difference was observed between the cytokine and the first-generation TKIs era cohort (HR: 1.12, 95% CI: 0.89–1.41, p = 0.341). Subgroup analyses stratified by the International Metastatic RCC Database Consortium (IMDC) risk groups showed a significantly longer OS in the modern TKIs/immunotherapy era as compared to first-generation TKIs and cytokines across all IMDC risk groups. Conclusion: Significant advances in the systemic medical treatment of mRCC during the recent decade and the introduction of immunotherapy exerted a major impact on patient outcomes in terms of OS in a real-life population.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2503443-1
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2006
    In:  Journal of Interpersonal Violence Vol. 21, No. 6 ( 2006-06), p. 774-797
    In: Journal of Interpersonal Violence, SAGE Publications, Vol. 21, No. 6 ( 2006-06), p. 774-797
    Abstract: The purpose of this study is to examine the longitudinal course of intimate partner violence (IPV) among female caregivers of children receiving child welfare services. Data are derived from the National Survey of Child and Adolescent Well-Being, a national probability study of children investigated for child abuse and neglect in the United States. Caregivers ( n = 861) are interviewed about demographic characteristics, mental health, substance use, and physical violence by a partner at the close of the investigation and at an 18-month follow-up. Polychotomous logistic regression examines the associations of severe and minor IPV controlling for caregiver and environmental characteristics. The results suggest that factors related to initial risk for IPV do not affect the continuation of IPV and that patterns of IPV differ for racial and ethnic groups.
    Type of Medium: Online Resource
    ISSN: 0886-2605 , 1552-6518
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2006
    detail.hit.zdb_id: 2028900-5
    SSG: 2
    SSG: 2,1
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  • 9
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 13 ( 2021-01), p. 175883592110399-
    Abstract: The level of evidence for palliative second-line therapy in advanced esophageal squamous cell carcinoma (aESCC) is limited. This is the first study that reports efficacy data comparing second-line therapy + active symptom control (ASC) versus ASC alone in aESCC. Methods: We conducted a tri-center retrospective cohort study ( n = 166) including patients with aESCC who had experienced disease progression on palliative first-line therapy. A propensity score model using inverse probability of treatment weighting (IPTW) was implemented for comparative efficacy analysis of overall survival (OS) in patients with second-line + ASC ( n = 92, 55%) versus ASC alone ( n = 74, 45%). Results: The most frequent second-line regimens used were docetaxel (36%) and paclitaxel (18%). In unadjusted primary endpoint analysis, second-line + ASC was associated with significantly longer OS compared with ASC alone [hazard ratio (HR) = 0.49, 95% confidence interval (CI): 0.35–0.69, p  〈  0.0001]. However, patients in the second-line + ASC group were characterized by more favorable baseline features including a better Eastern Cooperative Oncology Group (ECOG) performance status, a longer first-line treatment duration and lower C-reactive protein levels. After rigorous adjusting for baseline confounders by re-weighting the data with the IPTW the favorable association between second-line and longer OS weakened but prevailed. The median OS was 6.1 months in the second-line + ASC group and 3.2 months in the ASC group, respectively (IPTW-adjusted HR = 0.40, 95% CI: 0.24–0.69, p = 0.001). Importantly, the benefit of second-line was consistent across several clinical subgroups, including patients with ECOG performance status ⩾1 and age ⩾65 years. The most common grade 3 or 4 adverse events associated with palliative second-line therapy were hematological toxicities. Conclusion: This real-world study supports the concept that systemic second-line therapy prolongs survival in patients with aESCC.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2503443-1
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 1931
    In:  Journal of Education Vol. 113, No. 17 ( 1931-04), p. 449-449
    In: Journal of Education, SAGE Publications, Vol. 113, No. 17 ( 1931-04), p. 449-449
    Type of Medium: Online Resource
    ISSN: 0022-0574 , 2515-5741
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1931
    detail.hit.zdb_id: 2066577-5
    SSG: 5,3
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