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  • S. Karger AG  (2)
  • English  (2)
  • 1
    Online Resource
    Online Resource
    Acid Corrosive Injury in Patients with a History of Partial Gastrectomy: Outcome Analysis
    S. Karger AG ; 2007
    In:  Digestive Surgery Vol. 24, No. 3 ( 2007), p. 202-207
    Details
    In: Digestive Surgery, S. Karger AG, Vol. 24, No. 3 ( 2007), p. 202-207
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Our purpose was to delineate the characteristics and outcome of acid-corrosive injury in patients with a history of gastric resection. 〈 i 〉 Material and Methods: 〈 /i 〉 A total of 359 patients with a history of acid-corrosive injury were retrospectively reviewed. They were grouped based on past history with group 1 consisting of 8 patients with a history of gastric surgery (6 hemigastrectomies with Billroth II gastrojejunostomy, 2 partial gastrectomies with Billroth I gastroduodenostomy) and group 2 consisting of 351 patients without a history of previous gastric surgery. Clinical data, operative findings, treatment modalities and prognoses were compared. 〈 i 〉 Results: 〈 /i 〉 Group 1 patients required significantly more emergency surgical interventions (p = 0.016) and more frequent resection of alimentary necrosis (p = 0.007). In the operative findings of those undergoing emergency laparotomy, group 1 had a slightly higher incidence of total gastric necrosis with or without perforation (p = 0.388), and a higher incidence of jejunal resection (p = 0.001). However, group 1 patients had a relatively lower operative mortality rate compared to group 2 patients (p = 0.640). 〈 i 〉 Conclusion: 〈 /i 〉 Acid-injured patients with a history of previous gastric surgery tended to have a higher incidence of mandatory emergency surgical exploration and resection of the alimentary tract. With early and prompt management, a good survival rate can still be anticipated.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    URL: Article
    DOI: 10.1159/000102900
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2007
    detail.hit.zdb_id: 1468560-7
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  • 2
    Online Resource
    Online Resource
    Molecular Regulation of Bone Metastasis Pathogenesis
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 46, No. 4 ( 2018), p. 1423-1438
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 46, No. 4 ( 2018), p. 1423-1438
    Abstract: Distant metastases are the major cause of mortality in cancer patients. Bone metastases may cause bone fractures, local pain, hypercalcemia, bone marrow aplasia, and spinal cord compression. Therefore, the management of bone metastases is important in cancer treatment. Normal bone remodeling is regulated by osteoprotegerin ligand (OPGL), receptor activator of NF-κB ligand (RANKL), parathyroid hormone-related protein (PTHrP), and other cytokines. In the tumor microenvironment, tumor cells induce a vicious cycle that promotes osteoblastic and osteolytic lesions. Studies support the idea that distant metastases may occur due to the immunosuppressive function of myeloid-derived suppressor cells (MDSCs). These cells inhibit T cells and natural killer (NK) cells and differentiate into tumor-associating macrophages (TAMs), monocytes, and dendritic cells (DCs). In this review, we summarize studies focusing on the role of MDSCs in bone metastasis and provide a strong foundation for developing anticancer immune treatments and anticancer therapies, in general.
    Type of Medium: Online Resource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000489184
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2018
    detail.hit.zdb_id: 1482056-0
    SSG: 12
    SSG: 15,3
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