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  • S. Karger AG  (15)
  • 1
    Online-Ressource
    Online-Ressource
    Genome-Wide Association Studies for Albuminuria of Nondiabetic Taiwanese Population
    S. Karger AG ; 2023
    In:  American Journal of Nephrology
    Details
    In: American Journal of Nephrology, S. Karger AG
    Kurzfassung: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Nondiabetic individuals aged 30–70 years without a history of cancer were enrolled from the Taiwan Biobank. A total of 6,768 subjects were subjected to a spot urine examination. After quality control using PLINK and imputation using SHAPEIT and IMPUTE2, a total of 3,638,350 single-nucleotide polymorphisms (SNPs) remained for testing. SNPs with a minor allele frequency of less than 0.1% were excluded. Linear regression was used to determine the relationship between SNPs and log urine albumin-to-creatinine ratio. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Six suggestive loci are identified in or near the 〈 i 〉 FCRL3 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.56 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 TMEM161 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 4.43 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 EFCAB1 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.03 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 ELMOD1 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.97 × 10 〈 sup 〉 −6 〈 /sup 〉 ), 〈 i 〉 RYR3 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 1.34 × 10 〈 sup 〉 −6 〈 /sup 〉 ), and 〈 i 〉 PIEZO2 〈 /i 〉 ( 〈 i 〉 p 〈 /i 〉 = 2.19 × 10 〈 sup 〉 −7 〈 /sup 〉 ). Genetic variants in the 〈 i 〉 FCRL3 〈 /i 〉 gene that encode a secretory IgA receptor are found to be associated with IgA nephropathy, which can manifest as proteinuria. The 〈 i 〉 PIEZO2 〈 /i 〉 gene encodes a sensor for mechanical forces in mesangial cells and renin-producing cells. Five SNPs with a 〈 i 〉 p 〈 /i 〉 -value between 5 × 10 〈 sup 〉 −6 〈 /sup 〉 and 5 × 10 〈 sup 〉 −5 〈 /sup 〉 are also identified in five genes that may have a biological role in the development of albuminuria. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Five new loci and one known suggestive locus for albuminuria are identified in the nondiabetic Taiwanese population.
    Materialart: Online-Ressource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000531783
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2023
    ZDB Id: 1468523-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
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    Influence of Cytokine Gene Polymorphisms on Prostate-Specific Antigen Recurrence in Prostate Cancer after Radical Prostatectomy
    S. Karger AG ; 2009
    In:  Urologia Internationalis Vol. 83, No. 4 ( 2009), p. 463-470
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 83, No. 4 ( 2009), p. 463-470
    Kurzfassung: 〈 i 〉 Purpose: 〈 /i 〉 Evidence is accumulating indicating that chronic inflammation plays an important role in prostate cancer. We investigated the potential prognostic roles of 〈 i 〉 IL-6 〈 /i 〉 , 〈 i 〉 IL-8 〈 /i 〉 and 〈 i 〉 IL-10 〈 /i 〉 polymorphisms in clinical localized prostate cancer after radical prostatectomy. 〈 i 〉 Materials and Methods: 〈 /i 〉 A total of 116 clinically localized prostate cancer patients undergoing curative radical prostatectomy were included in this study. The 〈 i 〉 IL-6 〈 /i 〉 , 〈 i 〉 IL-8 〈 /i 〉 and 〈 i 〉 IL-10 〈 /i 〉 polymorphisms were determined by the TaqMan real-time PCR method. Their prognostic significance on prostate-specific antigen (PSA) recurrence was assessed using Kaplan-Meier analysis and Cox regression model. 〈 i 〉 Results: 〈 /i 〉 The 〈 i 〉 IL-6 〈 /i 〉 polymorphism (rs2066992) 〈 i 〉 T/G 〈 /i 〉 and 〈 i 〉 G/G 〈 /i 〉 genotype cases were associated with a higher percentage of preoperative PSA levels of ≥10 ng/ml; higher risk of positive surgical margin, and higher risk of extraprostatic extension compared to the 〈 i 〉 T/T 〈 /i 〉 genotype. The 〈 i 〉 IL-10 〈 /i 〉 polymorphism (rs1800871) 〈 i 〉 A/A 〈 /i 〉 genotype was associated with a higher risk of PSA recurrence compared with the 〈 i 〉 A/G 〈 /i 〉 + 〈 i 〉 G/G 〈 /i 〉 genotypes and significantly poorer PSA-free survival (log-rank test, p = 0.019). After considering other covariates in a Cox proportional hazard model, the 〈 i 〉 IL-10 〈 /i 〉 〈 i 〉 A/A 〈 /i 〉 genotype and high Gleason score (8–10) were still independent predictors of poor PSA-free survival. 〈 i 〉 Conclusion: 〈 /i 〉 Our results suggest that the 〈 i 〉 IL-10 〈 /i 〉 polymorphism may be a prognostic factor for PSA recurrence after radical prostatectomy.
    Materialart: Online-Ressource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000251189
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2009
    ZDB Id: 1464417-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington’s Disease
    S. Karger AG ; 2018
    In:  Cellular Physiology and Biochemistry Vol. 48, No. 2 ( 2018), p. 605-617
    Details
    In: Cellular Physiology and Biochemistry, S. Karger AG, Vol. 48, No. 2 ( 2018), p. 605-617
    Kurzfassung: Background/Aims: Huntington’s disease (HD) is a heritable neurodegenerative disorder, and there is no cure for HD to date. A type of fibroblast growth factor (FGF), FGF9, has been reported to play prosurvival roles in other neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. However, the effects of FGF9 on HD is still unknown. With many similarities in the cellular and pathological mechanisms that eventually cause cell death in neurodegenerative diseases, we hypothesize that FGF9 might provide neuroprotective functions in HD. Methods: In this study, STHdhQ7/Q7 (WT) and STHdhQ111/Q111 (HD) striatal knock-in cell lines were used to evaluate the neuroprotective effects of FGF9. Cell proliferation, cell death and neuroprotective markers were determined via the MTT assay, propidium iodide staining and Western blotting, respectively. The signaling pathways regulated by FGF9 were demonstrated using Western blotting. Additionally, HD transgenic mouse models were used to further confirm the neuroprotective effects of FGF9 via ELISA, Western blotting and immunostaining. Results: Results show that FGF9 not only enhances cell proliferation, but also alleviates cell death as cells under starvation stress. In addition, FGF9 significantly upregulates glial cell line-derived neurotrophic factor (GDNF) and an anti-apoptotic marker, Bcl-xL, and decreases the expression level of an apoptotic marker, cleaved caspase 3. Furthermore, FGF9 functions through ERK, AKT and JNK pathways. Especially, ERK pathway plays a critical role to influence the effects of FGF9 toward cell survival and GDNF production. Conclusions: These results not only show the neuroprotective effects of FGF9, but also clarify the critical mechanisms in HD cells, further providing an insight for the therapeutic potential of FGF9 in HD.
    Materialart: Online-Ressource
    ISSN: 1015-8987 , 1421-9778
    URL: Article
    DOI: 10.1159/000491889
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2018
    ZDB Id: 1482056-0
    SSG: 12
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Second-Trimester Placental Volume and Vascular Indices in the Prediction of Small-for-Gestational-Age Neonates
    S. Karger AG ; 2015
    In:  Fetal Diagnosis and Therapy Vol. 37, No. 2 ( 2015), p. 123-128
    Details
    In: Fetal Diagnosis and Therapy, S. Karger AG, Vol. 37, No. 2 ( 2015), p. 123-128
    Kurzfassung: 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To evaluate the ability of second-trimester placental volume and vascular indices to predict small-for-gestational-age (SGA) birth weight pregnancies. 〈 b 〉 〈 i 〉 Material and Methods: 〈 /i 〉 〈 /b 〉 Women with singleton pregnancies were prospectively evaluated at 17-20 weeks of gestation. Second-trimester placental volume and vascular indices were obtained and calculated using volume organ computer-aided analysis and three-dimensional (3D) power Doppler ultrasound. Participants were followed until delivery and their medical records were reviewed, including maternal age, parity and pregestational body weight and body height, as well as the gestational age, birth weight and gender of the fetus. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of the 163 women with complete follow-up, 20 gave birth to SGA and 143 to appropriate-for-gestational-age (AGA) neonates. The mean second-trimester placental volume was significantly lower in the SGA than in the AGA group (170.6 ± 49.8 vs. 213.5 ± 75.8 cm 〈 sup 〉 3 〈 /sup 〉 , p = 0.015). None of the vascular indices, including the vascularization index, flow index and vascularization flow index, differed significantly between the two groups. We also found that the optimum cutoff for placental volume at a gestational age of 17-18 weeks was 189.7 cm 〈 sup 〉 3 〈 /sup 〉 . 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 Second-trimester placental volume was positively correlated with neonatal birth weight. Second-trimester placental volume measured on 3D ultrasound may be predictive of SGA neonates.
    Materialart: Online-Ressource
    ISSN: 1015-3837 , 1421-9964
    URL: Article
    DOI: 10.1159/000365148
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2015
    ZDB Id: 1482292-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Effect of N-(Biphenylyl-Methyl)Imidazole, a Type 1 Angiotensin II Receptor Inhibitor,on the Co ntractile Function of the Rat Corpus cavernosum
    S. Karger AG ; 2000
    In:  Urologia Internationalis Vol. 64, No. 3 ( 2000), p. 149-153
    Details
    In: Urologia Internationalis, S. Karger AG, Vol. 64, No. 3 ( 2000), p. 149-153
    Kurzfassung: The effect of N-(biphenylyl-methyl)imidazole, losartan potassium, a newly developed antihypertensive type 1 angiotensin II receptor antagonist on the rat erectile function, was studied. Sexually active 9-week-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were given losartan 60 mg/kg intraperitoneal injections. Mean blood pressure (MBP) dropped significantly in both SHR and WKY rats (for SHR: from 140 ± 8 to 114 ± 5 mm Hg, p 〈 0.05, n = 8; for WKY: from 113 ± 7 to 79 ± 9 mm Hg, p 〈 0.05, n = 8). On the contrary, the intracavernous pressure (ICP) of SHR and WKY rats did not differ significantly from that of the corresponding controls receiving saline injections (p 〉 0.05, n = 8 for each group). For the chronic study, the rats were fed with losartan 30 mg/kg/day for 30 days. MBP decreased significantly in SHR but not in WKY rats (for SHR: from 137 ± 7 to 113 ± 5 mm Hg, p 〈 0.05, n = 8; for WKY: from 110 ± 6 to 107 ± 5 mm Hg, p 〉 0.05, n = 8). The ICP of the losartan-treated rats was not significantly different from that of control rats (p 〉 0.05, n = 8 for each group). In contrast, WKY rats receiving guanethidine 1 mg/kg/day for 30 days showed significantly decreased ICP. Angiotensin II (10 〈 sup 〉 –9 〈 /sup 〉 –10 〈 sup 〉 –5 〈 /sup 〉 〈 i 〉 M 〈 /i 〉 ) and losartan (10 〈 sup 〉 –9 〈 /sup 〉 – 10 〈 sup 〉 –5 〈 /sup 〉   〈 i 〉 M 〈 /i 〉 ) did not induce significant contractile responses of the cavernosal strip when tested in vitro. On the other hand, methoxamine 10 〈 sup 〉 –4 〈 /sup 〉 〈 i 〉 M 〈 /i 〉 induced good contractile responses. In conclusion, the present study demonstrated that angiotensin II did not cause significant change in the contractile status of rat corpus cavernosum. Correspondingly, the type 1 angiotensin II inhibitor effectively lowered blood pressure but did not affect cavernosal contractile function, thus is useful clinically in the treatment of hypertensive disorders without significant detrimental effects on male sexual function.
    Materialart: Online-Ressource
    ISSN: 0042-1138 , 1423-0399
    URL: Article
    DOI: 10.1159/000030516
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2000
    ZDB Id: 1464417-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Hong Kong Consensus Statements for the Management of Unresectable Hepatocellular Carcinoma
    S. Karger AG ; 2018
    In:  Liver Cancer Vol. 7, No. 1 ( 2018), p. 40-54
    Details
    In: Liver Cancer, S. Karger AG, Vol. 7, No. 1 ( 2018), p. 40-54
    Kurzfassung: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Hepatocellular carcinoma (HCC) is highly prevalent in Hong Kong due to the high prevalence of chronic hepatitis B infection. Liver cancer is the fourth most common cancer and the third most common cause of cancer death. Due to the high case load, there is a high level of local expertise in treating HCC, and the full spectrum of treatment modalities is available. This document summarizes how these modalities should be used based on the latest evidence. 〈 b 〉 〈 i 〉 Summary: 〈 /i 〉 〈 /b 〉 In 2 meetings held in early 2017, a multidisciplinary group of Hong Kong clinicians, including liver surgeons, interventional radiologists, clinical oncologists, and medical oncologists, met to update local consensus statements for management of HCC. These statements are based on the latest evidence and give detailed guidance on how to deploy these modalities, in particular for cases of HCC which are not suited to surgical resection. 〈 b 〉 〈 i 〉 Key Messages: 〈 /i 〉 〈 /b 〉 These statements give detailed information on how to decide if a patient is a candidate for resection, methods to improve candidacy for resection, and guidance for use of various nonsurgical interventions to manage patients ineligible for resection.
    Materialart: Online-Ressource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000485984
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2018
    ZDB Id: 2666925-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    High EREG Expression Is Predictive of Better Outcomes in Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy
    S. Karger AG ; 2020
    In:  Oncology Vol. 98, No. 8 ( 2020), p. 549-557
    Details
    In: Oncology, S. Karger AG, Vol. 98, No. 8 ( 2020), p. 549-557
    Kurzfassung: 〈 b 〉 〈 i 〉 Background/Aim: 〈 /i 〉 〈 /b 〉 A great proportion of patients with rectal cancer initially present with locally advanced disease and can potentially benefit from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before surgery. However, risk and clinical outcome stratification remain a great challenge. We aimed to find the potential biomarker to predict the effect of neoadjuvant CCRT on rectal cancer. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We identified epiregulin (EREG) as the most significant predictive marker for neoadjuvant CCRT response from the published rectal cancer transcriptome data set GSE35452. We collected 172 biopsy specimens from rectal cancer patients who received neoadjuvant CCRT followed by radical proctectomy, performed EREG immunohistochemistry, and analyzed the H-scores. We further examined the correlations between the expression level of EREG and clinicopathological features, tumor regression grade, and survival, including disease-specific survival (DSS), locoregional recurrence-free survival (LRFS), and metastasis-free survival (MeFS). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 High EREG expression was significantly related to early pretreatment (pre-Tx) and posttreatment (post-Tx) tumor status (T1, T2, 〈 i 〉 p 〈 /i 〉 = 0.047 and 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), pre-Tx and post-Tx negative nodal status (N0, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001 and 〈 i 〉 p 〈 /i 〉 = 0.004), less vascular and perineurial invasion ( 〈 i 〉 p 〈 /i 〉 = 0.015 and 〈 i 〉 p 〈 /i 〉 = 0.023), and higher tumor regression grade ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). In the survival analysis, high EREG expression was significantly associated with better DSS ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001), LRFS ( 〈 i 〉 p 〈 /i 〉 = 0.0004), and MeFS ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001). In the multivariate analysis, high EREG expression remained prognostically significant for better DSS ( 〈 i 〉 p 〈 /i 〉 = 0.003; hazard ratio: 5.599). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 These data suggest that EREG is a potential predictive marker and therapeutic target in rectal cancer patients receiving neoadjuvant CCRT.
    Materialart: Online-Ressource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000506991
    RVK:
    XH 3305
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2020
    ZDB Id: 1483096-6
    ZDB Id: 250101-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Consensus for Radiotherapy in Hepatocellular Carcinoma from The 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014): Current Practice and Future Clinical Trials
    S. Karger AG ; 2016
    In:  Liver Cancer Vol. 5, No. 3 ( 2016), p. 162-174
    Details
    In: Liver Cancer, S. Karger AG, Vol. 5, No. 3 ( 2016), p. 162-174
    Kurzfassung: A consensus meeting to develop practice guidelines and to recommend future clinical trials for radiation therapy (RT), including external beam RT (EBRT), and selective internal RT (SIRT) in hepatocellular carcinoma (HCC) was held at the 5th annual meeting of the Asia-Pacific Primary Liver Cancer Expert consortium. Although there is no randomized phase III trial evidence, the efficacy and safety of RT in HCC has been shown by prospective and retrospective studies using modern RT techniques. Based on these results, the committee came to a consensus on the utility and efficacy of RT in the management of HCC according to each disease stage as follows: in early and intermediate stage HCC, if standard treatment is not compatible, RT, including EBRT and SIRT can be considered. In locally advanced stage HCC, combined EBRT with transarterial chemoembolization or hepatic arterial infusion chemotherapy, and SIRT can be considered. In terminal stage HCC, EBRT can be considered for palliation of symptoms and reduction of morbidity caused by the primary tumor or its metastases. Despite the currently reported benefits of RT in HCC, the committee agreed that there is a compelling need for large prospective studies, including randomized phase III trial evidence evaluating the role of RT. Specifically studies evaluating the efficacy and safety of sequential combination of EBRT and SIRT are strongly recommended.
    Materialart: Online-Ressource
    ISSN: 2235-1795 , 1664-5553
    URL: Article
    DOI: 10.1159/000367766
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2016
    ZDB Id: 2666925-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Impact of Spiritual and Religious Activity on Quality of Sleep in Hemodialysis Patients
    S. Karger AG ; 2008
    In:  Blood Purification Vol. 26, No. 3 ( 2008), p. 221-225
    Details
    In: Blood Purification, S. Karger AG, Vol. 26, No. 3 ( 2008), p. 221-225
    Kurzfassung: 〈 i 〉 Background: 〈 /i 〉 Sleep disorders are common in hemodialysis (HD) patients. This study examined the relationship between quality of sleep (QoS) and religious/spiritual activity in HD patients. 〈 i 〉 Methods: 〈 /i 〉 The study subjects were 861 HD patients from 14 dialysis clinics in Taiwan. QoS and religious/spiritual activity were evaluated by the Pittsburgh Sleep Quality Index (PSQI) questionnaire and the Royal Free Questionnaire respectively. 〈 i 〉 Results: 〈 /i 〉 There was no difference in clinical parameters between the good and poor sleepers. Although total scores of religious and spiritual activity did not correlate with global PSQI score, patients who held strong ‘spiritual’ beliefs reported more problems in ‘sleep disturbances’, while those who exercised religious beliefs more strongly reported less trouble in ‘daytime dysfunction’. 〈 i 〉 Conclusion: 〈 /i 〉 There is no significant correlation between QoS and religious/spiritual activity globally. However, the spiritual and religious activity did associate with different components of QoS.
    Materialart: Online-Ressource
    ISSN: 0253-5068 , 1421-9735
    URL: Article
    DOI: 10.1159/000118845
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 2008
    ZDB Id: 1482025-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Successful Treatment of Metastatic Endophthalmitis
    S. Karger AG ; 1989
    In:  Ophthalmologica Vol. 198, No. 3 ( 1989), p. 124-128
    Details
    In: Ophthalmologica, S. Karger AG, Vol. 198, No. 3 ( 1989), p. 124-128
    Materialart: Online-Ressource
    ISSN: 1423-0267 , 0030-3755
    URL: Article
    DOI: 10.1159/000309973
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: S. Karger AG
    Publikationsdatum: 1989
    ZDB Id: 1483531-9
    Standort Signatur Einschränkungen Verfügbarkeit
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