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  • S. Karger AG  (21)
  • English  (21)
  • 11
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    Online Resource
    Successful Treatment of Advanced Thymic Carcinoma with Carboplatin plus 〈b〉〈i〉nab〈/i〉〈/b〉-Paclitaxel and Maintenance Monotherapy with 〈b〉〈i〉nab〈/i〉〈/b〉-Paclitaxel: Two Case Reports
    S. Karger AG ; 2020
    In:  Case Reports in Oncology Vol. 13, No. 3 ( 2020-12-17), p. 1506-1512
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 13, No. 3 ( 2020-12-17), p. 1506-1512
    Abstract: A standard chemotherapy regimen for advanced thymic carcinoma has not yet been established. We treated 2 cases of thymic carcinoma with carboplatin plus nanoparticle albumin-bound ( 〈 i 〉 nab 〈 /i 〉 )-paclitaxel, and 〈 i 〉 nab 〈 /i 〉 -paclitaxel maintenance therapy. The first case was a 68-year-old female, admitted for dyspnea and left shoulder pain. Chest computed tomography (CT) showed a huge mass in the anterior mediastinum, pleural and pericardial effusions, and multiple lung metastases. Specimens obtained from the anterior mediastinal mass by CT-guided needle biopsy revealed squamous cell carcinoma of the thymus, which was in stage IVB. The patient was administered carboplatin plus 〈 i 〉 nab 〈 /i 〉 -paclitaxel as first-line treatment. After 3 cycles of chemotherapy, a partial response was observed with marked shrinkage of the tumor. Following 6 cycles of chemotherapy, 〈 i 〉 nab 〈 /i 〉 -paclitaxel maintenance therapy was initiated. Disease progression was seen 9.1 months after initiation of treatment. The patient experienced no serious adverse events. The second case was a 70-year-old male who had productive cough, dyspnea, and right-sided chest pain. Chest CT revealed a huge mass in the anterior mediastinum, pericardial effusion, and multiple lymphadenopathies. Specimens obtained from station 11s by endobronchial ultrasound-guided transbronchial needle aspiration revealed undifferentiated thymic carcinoma, which was in stage IVB. Six cycles of carboplatin plus 〈 i 〉 nab 〈 /i 〉 -paclitaxel were administered, followed by 5 cycles of 〈 i 〉 nab 〈 /i 〉 -paclitaxel for maintenance. A partial response was seen, which was sustained for more than 13 months. The patient experienced no serious adverse events. These cases show that chemotherapy with carboplatin plus 〈 i 〉 nab 〈 /i 〉 -paclitaxel and 〈 i 〉 nab 〈 /i 〉 -paclitaxel as maintenance therapy can be a useful regimen for advanced thymic carcinoma.
    Type of Medium: Online Resource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000510894
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2458961-5
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  • 12
    Online Resource
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    Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases
    S. Karger AG ; 2022
    In:  Case Reports in Oncology Vol. 15, No. 2 ( 2022-6-7), p. 599-605
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 15, No. 2 ( 2022-6-7), p. 599-605
    Abstract: Myoepithelial neoplasms (MNs) of the lung are extremely rare tumors. Approximately 40 cases of pulmonary MNs have been reported to date. Herein, we report extremely rare cases of different types of pulmonary MN, including cytological features. Case 1 is an 18-year-old female, and case 2 is a 73-year-old female patient. They presented to our hospital with nodules of the lung. Histological examination revealed tumor cells with round to oval nuclei and acidophilic cytoplasm that formed nests or fascicles with mild hyalinized stroma in case 1 and tumors containing the bi-phasic components of a nest-like and fascicle pattern with pleomorphism in case 2. Immunohistochemically, these tumors were positive for cytokeratin (CK) AE1/AE3, CK5/6, vimentin, calponin, and EMA, and focal positive for S-100a protein and alpha smooth muscle actin. The pathological diagnoses in cases 1 and 2 were myoepithelioma and myoepithelial carcinoma, respectively. In conclusion, we encountered two cases of extremely rare MNs that occurred in the lung. This disease can be diagnosed by collecting appropriate cytological and histological findings and should be listed as a differential diagnosis.
    Type of Medium: Online Resource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000524769
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2022
    detail.hit.zdb_id: 2458961-5
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  • 13
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    Intestinal Behçet’s Disease with Primary Myelofibrosis Involving Trisomy 8
    S. Karger AG ; 2019
    In:  Acta Haematologica Vol. 142, No. 4 ( 2019), p. 253-256
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 142, No. 4 ( 2019), p. 253-256
    Abstract: Behçet’s disease (BD) is a disorder characterized by systemic inflammation of multiple organs, including the intestines. Several studies have reported a relationship between myelodysplastic syndrome and BD, and trisomy 8 was frequently seen, especially in intestinal BD. However, the association of BD with primary myelofibrosis (PMF) has not been well documented. A 58-year-old Japanese female was diagnosed with PMF in 2014. The symptoms of PMF resolved with ruxolitinib. However, she developed fever and intestinal perforation due to multiple ulcers in the terminal ileum in 2017. Intestinal perforation recurred 1 month later, and the dose of ruxolitinib was tapered. After discontinuation of ruxolitinib, she presented with recurrent oral aphthous ulcers and uveitis. Subsequently, intestinal perforation recurred, and she was diagnosed with intestinal BD. Trisomy 8 was identified in her peripheral blood. She underwent steroid therapy, azathioprine, and infliximab. This case suggests relationships between PMF, trisomy 8, and BD.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000501019
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2019
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 14
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    Acute Generalized Exanthematous Pustulosis Caused by Erlotinib in a Patient with Lung Cancer
    S. Karger AG ; 2021
    In:  Case Reports in Oncology Vol. 14, No. 1 ( 2021-3-29), p. 599-603
    Details
    In: Case Reports in Oncology, S. Karger AG, Vol. 14, No. 1 ( 2021-3-29), p. 599-603
    Abstract: Acute generalized exanthematous pustulosis (AGEP) is a rare drug-related adverse skin reaction caused mainly by antibiotics. Erlotinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used to treat lung cancer. A 69-year-old woman with primary lung cancer (adenocarcinoma, cT3N1M1b, stage IVB) developed erythema and multiple skin pustules on her abdomen and both thighs after 7 weeks of erlotinib treatment. She also had fever and general fatigue. Histological examination of a skin biopsy specimen showed intraepidermal pustules with neutrophil and eosinophil infiltration. She was diagnosed with erlotinib-induced AGEP. AGEP resolved by erlotinib discontinuation and systemic corticosteroid treatment. The lung cancer progressed when erlotinib was discontinued, so afatinib, a second-generation EGFR-TKI, was administrated without any skin adverse effects. Afatinib successfully decreased the lung cancer, and maintained the disease stable for 1 year. Although acneiform rash was the most common skin adverse event caused by EGFR, AGEP rarely occurred. The present case also demonstrated that it is possible to switch agents, from erlotinib to afatinib, even though they have the same pharmacological effects. Although AGEP is a rare drug-related skin disorder, physicians should be aware that erlotinib may induce AGEP.
    Type of Medium: Online Resource
    ISSN: 1662-6575
    URL: Article
    DOI: 10.1159/000514146
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
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  • 15
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    Interleukin-33 and Soluble ST2 Levels in Infants with Hypoxic-Ischemic Encephalopathy
    S. Karger AG ; 2023
    In:  Neonatology Vol. 120, No. 3 ( 2023), p. 353-362
    Details
    In: Neonatology, S. Karger AG, Vol. 120, No. 3 ( 2023), p. 353-362
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Interleukin (IL)-33 and its receptor ST2L play key roles in the IL-33/ST2 signaling pathway. Soluble ST2 (sST2) inhibits the proper function of IL-33. sST2 levels are increased in patients with several neurological diseases, but in infants with hypoxic-ischemic encephalopathy (HIE), IL-33 and sST2 levels have not been studied. This study aimed to investigate whether serum levels of IL-33 and sST2 are useful as biomarkers of HIE severity and prognostic factors for infants with HIE. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Twenty-three infants with HIE and 16 controls (gestational age ≥36 weeks and ≥1,800 g birth weight) were enrolled in this study. Serum levels of IL-33 and sST2 were measured at & #x3c;6 h, 1–2, 3, and 7 days of age. Hydrogen-1 magnetic resonance spectroscopy was performed, and ratios of peak integrals of lactate/N-acetylaspartate (Lac/NAA) were calculated as objective indicators of brain damage. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In the moderate and severe HIE, serum sST2 concentrations were increased and there was a good correlation between serum sST2 and HIE severity on days 1–2, whereas no variation was observed in serum IL-33. Serum sST2 levels were positively correlated with Lac/NAA ratios (Kendall’s rank correlation coefficient = 0.527, 〈 i 〉 p 〈 /i 〉 = 0.024), and both sST2 and Lac/NAA ratios were significantly higher in HIE infants with neurological impairment ( 〈 i 〉 p 〈 /i 〉 = 0.020 and & #x3c;0.001, respectively). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 sST2 may be a useful predictor of severity and later neurological outcomes in infants with HIE. Further investigation is required to elucidate the relationship between the IL-33/ST2 axis and HIE.
    Type of Medium: Online Resource
    ISSN: 1661-7800 , 1661-7819
    URL: Article
    DOI: 10.1159/000529679
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 2403535-X
    SSG: 12
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  • 16
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    Profiling Surgical Staplers: Does Staple Direction Affect the Strength of the Anastomosis?
    S. Karger AG ; 2015
    In:  Digestive Surgery Vol. 32, No. 6 ( 2015), p. 454-458
    Details
    In: Digestive Surgery, S. Karger AG, Vol. 32, No. 6 ( 2015), p. 454-458
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Few studies have been conducted regarding the optimal staple direction in gastrointestinal anastomosis. The purpose of this study was to evaluate the burst pressure of the anastomosis depending on the firing direction of the stapler. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Pig esophagus and small bowel were used for all experiments. The small intestine represented a thin intestinal tract and the esophagus represented a thick intestinal tract. A side-to-side anastomosis was performed using a linear stapler, and the burst pressure was measured. A leak test on the anastomosis was then performed and burst pressures measured. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Burst pressures after anastomosis using a GIA™ 100-3.8 were 47.4 ± 10.4 mm Hg. With the same GIA, the burst pressure was significantly greater when the staples were driven from the small intestine into the esophagus (83.3 ± 17.3 mm Hg). Using the GIA™ 100-4.8, it was found that the burst pressure was significantly greater when the staplers were driven into the small intestine versus the esophagus (51.6 ± 7.1 vs. 68.6 ± 16.1 mm Hg). There was no significant difference between the different GIAs when fired in the same direction. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Burst pressures were significantly greater when the staplers were driven from the small intestine into the esophagus. The direction of the staple line influences the strength of the anastomosis.
    Type of Medium: Online Resource
    ISSN: 0253-4886 , 1421-9883
    URL: Article
    DOI: 10.1159/000440817
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1468560-7
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  • 17
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    Sternocleidomastoid Muscle Thickness Correlates with Exercise Tolerance in Patients with COPD
    S. Karger AG ; 2023
    In:  Respiration Vol. 102, No. 1 ( 2023), p. 64-73
    Details
    In: Respiration, S. Karger AG, Vol. 102, No. 1 ( 2023), p. 64-73
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Patients with chronic obstructive pulmonary disease (COPD) have difficulties inhaling as the diaphragm becomes flattened and weakened due to lung hyperinflation. This weakened respiratory function is compensated for by the increased activity of the accessory respiratory muscles, such as the sternocleidomastoid muscle (SCM). 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 This study aimed to evaluate the difference in the SCM thickening fraction (SCM TF) of each respiratory phase (end-expiration, resting inspiration, and end-inspiration), as measured using ultrasonography (US), between patients with COPD and control subjects. We also evaluate the correlation between the SCM TF of each respiratory phase and exercise tolerance in patients with COPD. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients with COPD ( 〈 i 〉 n 〈 /i 〉 = 44) and age-matched controls ( 〈 i 〉 n 〈 /i 〉 = 20) underwent US for determination of the SCM TF. Ventilation parameters, including the peak oxygen uptake (peak VO 〈 sub 〉 2 〈 /sub 〉 ) and the change in the inspiratory capacity, were measured during cardiopulmonary exercise testing. The SCM thickness and TF was measured during end-expiration, resting breathing, and end-inspiration. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The SCM was significantly thinner in patients with COPD than in controls at end-expiration. The increase in the SCM TF from end-expiration to end-inspiration in patients with COPD did not differ significantly from that in control subjects. In contrast, the SCM TF from end-expiration to resting inspiration was significantly greater in patients with COPD than in control subjects. The peak VO 〈 sub 〉 2 〈 /sub 〉 was strongly positively correlated with the SCM TF from end-expiration to end-inspiration in patients with COPD ( 〈 i 〉 r 〈 /i 〉 = 0.71, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.01). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The SCM may be thinner in patients with COPD than in controls. The SCM TF may also be associated with exercise tolerance.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000527100
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 1464419-8
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  • 18
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    Early Recurrence of Immunoglobulin A Nephropathy after Kidney Transplantation in a Patient with Down Syndrome
    S. Karger AG ; 2023
    In:  Nephron
    Details
    In: Nephron, S. Karger AG
    Abstract: A 39-year-old male kidney transplant recipient with Down syndrome (DS) was admitted to our hospital for biopsy. He had proteinuria at age 9, was diagnosed with immunoglobulin A nephropathy (IgAN) at age 22, had a tonsillectomy at age 35, and underwent ABO-compatible kidney transplantation (from his mother) at age 36. His serum creatinine was stable at 2.21 mg/dL 3 months after the kidney transplant, and his urine protein was 0.11 g/day. A protocol biopsy was performed 7 months after the kidney transplant, and there was suspicion of early recurrence of IgAN. One year after the transplant, urine erythrocytes were elevated and proteinuria was 0.41 g/day; at 3 years and 5 months after the kidney transplant, hematuria was evident along with proteinuria (0.74 g/day). Therefore, an episode biopsy was performed. A total of 23 glomeruli were obtained, four of which exhibited global sclerosis; three others showed intra- and extracapillary proliferative glomerulonephritis compatible with IgAN recurrence. Here, we report a rare case of early recurrence of IgAN with disease progression despite tonsillectomy in a patient with DS.
    Type of Medium: Online Resource
    ISSN: 1660-8151 , 2235-3186
    URL: Article
    DOI: 10.1159/000530915
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2023
    detail.hit.zdb_id: 2810853-X
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  • 19
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    Statistical Parametric Analysis of Cerebral Blood Flow in Vascular Dementia with Small-Vessel Disease Using 〈sup〉99m〈/sup〉Tc-HMPAO SPECT
    S. Karger AG ; 2008
    In:  Cerebrovascular Diseases Vol. 26, No. 5 ( 2008), p. 556-562
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 26, No. 5 ( 2008), p. 556-562
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Subcortical ischemic vascular dementia (SVD) caused by small-artery disease is a major cause of dementia. It still remains unclear, however, whether SVD may present with localized regional cerebral blood flow (rCBF) changes. We aimed to clarify the local rCBF changes associated with dementia in patients with early-stage SVD. 〈 i 〉 Methods: 〈 /i 〉 The subjects consisted of 15 patients with early-stage SVD [Mini Mental State Examination (MMSE) score: 20 ± 3.5] without apparent brain atrophy (SVD group), 11 patients without dementia with white matter lesions (non-dementia-WML group) and 16 age-matched controls. All the subjects were right-handed and underwent brain perfusion single photon emission computed tomography (SPECT), magnetic resonance imaging and cognitive function testing. Statistical analysis of the differences in the SPECT rCBF was performed by SPM2. The degree of severity of the WMLs was evaluated based on the Scheltens rating scale. 〈 i 〉 Results: 〈 /i 〉 The results of SPM analysis revealed that the rCBF in the SVD group was significantly decreased in the pulvinar nuclei of the thalamus of both sides as compared with that in the controls, and in the left pulvinar nucleus as compared with that in the non-dementia-WML group. On the other hand, SPM analysis revealed no significant reduction in rCBF in the non-dementia-WML group as compared with that in the controls. The WMLs in the left parietal region were severer in the SVD group than in the non-dementia-WML group. 〈 i 〉 Conclusions: 〈 /i 〉 In patients with early-stage SVD without apparent brain atrophy, significant rCBF reduction in the bilateral pulvinar nuclei as compared with that in normal controls, and in the left pulvinar nucleus as compared with that in patients without dementia with WMLs was found.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000160213
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2008
    detail.hit.zdb_id: 1482069-9
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  • 20
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    A Case of Leukemic Mastocytoma Terminating in Metamorphosis
    S. Karger AG ; 1986
    In:  Acta Haematologica Vol. 75, No. 1 ( 1986), p. 40-45
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 75, No. 1 ( 1986), p. 40-45
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000206079
    Language: English
    Publisher: S. Karger AG
    Publication Date: 1986
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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