In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-8), p. e0248884-
Abstract:
Even with increasing awareness of sex-related differences in atherosclerotic cardiovascular disease (ASCVD), it remains unclear whether the progression of coronary atherosclerosis differs between women and men. We sought to compare coronary artery calcium (CAC) progression between women and men. From a retrospective, multicentre registry of consecutive asymptomatic individuals who underwent CAC scoring, we identified 9,675 men and 1,709 women with follow-up CAC scoring. At baseline, men were more likely to have a CAC score 〉 0 than were women (47.8% vs. 28.6%). The probability of CAC progression at 5 years, defined as [√CAC score (follow-up)—√CAC score (baseline)] ≥2.5, was 47.4% in men and 29.7% in women ( p 〈 0.001). When we stratified subjects according to the 10-year ASCVD risk ( 〈 5%, ≥5% and 〈 7.5%, and ≥7.5%), a sex difference was observed in the low risk group (CAC progression at 5 years, 37.6% versus 17.9%; p 〈 0.001). However, it became weaker as the 10-year ASCVD risk increased (64.2% versus 46.2%; p 〈 0.001, and 74.8% versus 68.7%; p = 0.090). Multivariable analysis demonstrated that male sex was independently associated with CAC progression rate among the entire group ( p 〈 0.001). Subgroup analyses showed an independent association between male sex and CAC progression rate only in the low-risk group. The CAC progression rate is higher in men than in women. However, the difference between women and men diminishes as the 10-year ASCVD risk increases.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0248884
DOI:
10.1371/journal.pone.0248884.g001
DOI:
10.1371/journal.pone.0248884.g002
DOI:
10.1371/journal.pone.0248884.g003
DOI:
10.1371/journal.pone.0248884.g004
DOI:
10.1371/journal.pone.0248884.t001
DOI:
10.1371/journal.pone.0248884.t002
DOI:
10.1371/journal.pone.0248884.t003
DOI:
10.1371/journal.pone.0248884.s001
DOI:
10.1371/journal.pone.0248884.s002
DOI:
10.1371/journal.pone.0248884.s003
DOI:
10.1371/journal.pone.0248884.r001
DOI:
10.1371/journal.pone.0248884.r002
DOI:
10.1371/journal.pone.0248884.r003
DOI:
10.1371/journal.pone.0248884.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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