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  • MDPI AG  (7)
  • Englisch  (7)
  • 1
    Online-Ressource
    Online-Ressource
    LC–MS3 Strategy for Quantification of Carbamazepine in Human Plasma and Its Application in Therapeutic Drug Monitoring
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 4 ( 2022-02-11), p. 1224-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 4 ( 2022-02-11), p. 1224-
    Kurzfassung: This study developed a detection method based on the strategy of HPLC/MS3 and verified its suitability by quantifying carbamazepine in human plasma. The high-performance liquid chromatography–tandem mass spectrometry (HPLC/MS3) system was performed using a Shimadzu UFLC XR liquid chromatography and a SCIEX QTRAP® 5500 linear ion trap triple quadrupole mass spectrometer. The specific operation was as follows: the sample protein was firstly precipitated using methanol, then carbamazepine and carbamazepine-D2N15 were separated on an ACQUITY UPLC HSS T3 column using the gradient elution with solvent A (0.1% formic acid) and solvent B (0.1% formic acid in acetonitrile) at a flow rate of 0.25 mL/min. Each sample was run for 7 min. This method was validated for various parameters including accuracy, precision, selectivity, linearity, LLOQ, etc. Only 5 μL of sample plasma could obtain the result of LLOD 0.5 µg/mL. The intra-day and inter-day precision was 〈 8.23%, and accuracy was between −1.74% and 2.92%. This method was successfully used for monitoring the blood concentration of epilepsy patients after carbamazepine treatment.
    Materialart: Online-Ressource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27041224
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2008644-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Genetic Analyses Confirm SNPs in HSPA8 and ERBB2 are Associated with Milk Protein Concentration in Chinese Holstein Cattle
    MDPI AG ; 2019
    In:  Genes Vol. 10, No. 2 ( 2019-01-30), p. 104-
    Details
    In: Genes, MDPI AG, Vol. 10, No. 2 ( 2019-01-30), p. 104-
    Kurzfassung: Heat shock 70 kDa protein 8 (HSPA8) and erb-b2 receptor tyrosine kinase 2 (ERBB2) were the promising candidates for milk protein concentration in dairy cattle revealed through previous RNA sequencing (RNA-Seq) study. The objective of this post-RNA-Seq study was to confirm genetic effects of HSPA8 and ERBB2 on milk protein concentration in a large Chinese Holstein population and to evaluate the genetic effects of both genes on other milk production traits. There were 2 singlenucleotide polymorphisms (SNPs) identified for HSPA8 and 11 SNPs for ERBB2 by sequencing 17 unrelated Chinese Holstein sires. The SNP-rs136632043 in HSPA8 had significant associations with all five milk production traits (p = 0.0086 to p 〈 0.0001), whereas SNP-rs132976221 was remarkably associated with three yield traits (p 〈 0.0001). Nine (ss1996900615, rs109017161, rs109122971, ss1996900614, rs110133654, rs109941438, rs110552983, rs133031530, and rs109763505) of 11 SNPs in ERBB2 were significantly associated with milk protein percentage (p = 0.0177 to p 〈 0.0001). A 12 Kb haplotype block was formed in ERBB2 and haplotype associations revealed similar effects on milk protein traits. Our findings confirmed the significant genetic effects of HSPA8 and ERBB2 on milk protein concentration and other milk production traits and SNP phenotypic variances above 1% may serve as genetic markers in dairy cattle breeding programs.
    Materialart: Online-Ressource
    ISSN: 2073-4425
    URL: Article
    DOI: 10.3390/genes10020104
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2019
    ZDB Id: 2527218-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Coordinated Control for the Trajectory Tracking of Four-Wheel Independent Drive–Four-Wheel Independent Steering Electric Vehicles Based on the Extension Dynamic Stability Domain
    MDPI AG ; 2024
    In:  Actuators Vol. 13, No. 2 ( 2024-02-16), p. 77-
    Details
    In: Actuators, MDPI AG, Vol. 13, No. 2 ( 2024-02-16), p. 77-
    Kurzfassung: In order to achieve multi-objective chassis coordination control for 4WID-4WIS (four-wheel independent drive–four-wheel independent steering) electric vehicles, this paper proposes a coordinated control strategy based on the extension dynamic stability domain. The strategy aims to improve trajectory tracking performance, handling stability, and economy. Firstly, expert PID and model predictive control (MPC) are used to achieve longitudinal speed tracking and lateral path tracking, respectively. Then, a sliding mode controller is designed to calculate the expected yaw moment based on the desired vehicle states. The extension theory is applied to construct the extension dynamic stability domain, taking into account the linear response characteristics of the vehicle. Different coordinated allocation strategies are devised within various extension domains, providing control targets for direct yaw moment control (DYC) and active rear steering (ARS). Additionally, a compound torque distribution strategy is formulated to optimize driving efficiency and tire adhesion rate, considering the vehicle’s economy and stability requirements. The optimal wheel torque is calculated based on this strategy. Simulation tests using the CarSim/Simulink co-simulation platform are conducted under slalom test and double-lane change to validate the control strategy. The test results demonstrate that the proposed control strategy not only achieves good trajectory tracking performance but also enhances handling stability and economy during driving.
    Materialart: Online-Ressource
    ISSN: 2076-0825
    URL: Article
    DOI: 10.3390/act13020077
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2024
    ZDB Id: 2682469-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Flexible Textile-Based Sweat Sensors for Wearable Applications
    MDPI AG ; 2023
    In:  Biosensors Vol. 13, No. 1 ( 2023-01-12), p. 127-
    Details
    In: Biosensors, MDPI AG, Vol. 13, No. 1 ( 2023-01-12), p. 127-
    Kurzfassung: The current physical health care system has gradually evolved into a form of virtual hospitals communicating with sensors, which can not only save time but can also diagnose a patient’s physical condition in real time. Textile-based wearable sensors have recently been identified as detection platforms with high potential. They are developed for the real-time noninvasive detection of human physiological information to comprehensively analyze the health status of the human body. Sweat comprises various chemical compositions, which can be used as biomarkers to reflect the relevant information of the human physiology, thus providing references for health conditions. Combined together, textile-based sweat sensors are more flexible and comfortable than other conventional sensors, making them easily integrated into the wearable field. In this short review, the research progress of textile-based flexible sweat sensors was reviewed. Three mechanisms commonly used for textile-based sweat sensors were firstly contrasted with an introduction to their materials and preparation processes. The components of textile-based sweat sensors, which mainly consist of a sweat transportation channel and collector, a signal-selection unit, sensing elements and sensor integration and communication technologies, were reviewed. The applications of textile-based sweat sensors with different mechanisms were also presented. Finally, the existing problems and challenges of sweat sensors were summarized, which may contribute to promote their further development.
    Materialart: Online-Ressource
    ISSN: 2079-6374
    URL: Article
    DOI: 10.3390/bios13010127
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2662125-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    A Process-Based, Fully Distributed Soil Erosion and Sediment Transport Model for WRF-Hydro
    MDPI AG ; 2020
    In:  Water Vol. 12, No. 6 ( 2020-06-26), p. 1840-
    Details
    In: Water, MDPI AG, Vol. 12, No. 6 ( 2020-06-26), p. 1840-
    Kurzfassung: A soil erosion and sediment transport model (WRF-Hydro-Sed) is introduced to WRF-Hydro. As a process-based, fully distributed soil erosion model, WRF-Hydro-Sed accounts for both overland and channel processes. Model performance is evaluated using observed rain gauge, streamflow, and sediment concentration data during rainfall events in the Goodwin Creek Experimental Watershed in Mississippi, USA. Both streamflow and sediment yield can be calibrated and validated successfully at a watershed scale during rainfall events. Further discussion reveals the model’s uncertainty and the applicability of calibrated hydro- and sediment parameters to different events. While an intensive calibration over multiple events can improve the model’s performance to a certain degree compared with single event-based calibration, it might not be an optimal strategy to carry out considering the tremendous computational resources needed.
    Materialart: Online-Ressource
    ISSN: 2073-4441
    URL: Article
    DOI: 10.3390/w12061840
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2020
    ZDB Id: 2521238-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Serum Vitamin D Concentrations, Time to Pregnancy, and Pregnancy Outcomes among Preconception Couples: A Cohort Study in Shanghai, China
    MDPI AG ; 2022
    In:  Nutrients Vol. 14, No. 15 ( 2022-07-26), p. 3058-
    Details
    In: Nutrients, MDPI AG, Vol. 14, No. 15 ( 2022-07-26), p. 3058-
    Kurzfassung: Background: The role of vitamin D in reproductive health is still unclear. This study aimed to assess the effect of serum 25-hydroxyvitamin D (25(OH)D), among preconception couples, on fecundity, and the associations between 25(OH)D concentrations before and during pregnancy, and pregnancy outcomes. Methods: 200 preconception couples attempting to conceive were recruited and were followed-up until childbirth. Time to pregnancy was collected via telephone every two months or obtained via a questionnaire during pregnancy. Blood samples were collected to measure serum 25(OH)D levels from both partners at enrollment and from women during the second and third trimester of pregnancy. Results: Couples had higher conception rates within six months (adjusted odds ratio (aOR): 3.72, 95% CI: 1.16, 11.9) and reduced time to pregnancy (adjusted fecundability ratio (aFR): 1.50, 95% CI: 1.01, 2.23) if male partners had sufficient 25(OH)D compared with insufficient 25(OH)D. Compared to pregnant women with insufficient 25(OH)D in the third trimester of pregnancy, sufficient 25(OH)D was associated with reduced odds of anemia (OR: 0.22, 95% CI: 0.06, 0.82), longer gestational age (β: 0.53, 95% CI: 0.04, 1.01) and newborns’ higher ponderal index (β: 0.10, 95% CI: 0.01, 0.19). Conclusions: Sufficient serum 25(OH)D levels among preconception men or during pregnancy were associated with better reproductive health.
    Materialart: Online-Ressource
    ISSN: 2072-6643
    URL: Article
    DOI: 10.3390/nu14153058
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2518386-2
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  • 7
    Online-Ressource
    Online-Ressource
    Smart Mask as Wearable for Post-Pandemic Personal Healthcare
    MDPI AG ; 2023
    In:  Biosensors Vol. 13, No. 2 ( 2023-01-30), p. 205-
    Details
    In: Biosensors, MDPI AG, Vol. 13, No. 2 ( 2023-01-30), p. 205-
    Kurzfassung: A mask serves as a simple external barrier that protects humans from infectious particles from poor air conditions in the surrounding environment. As an important personal protective equipment (PPE) to protect our respiratory system, masks are able not only to filter pathogens and dust particles but also to sense, reflect or even respond to environmental conditions. This smartness is of particular interest among academia and industries due to its potential in disease detection, health monitoring and caring aspects. In this review, we provide an overlook of the current air filtration strategies used in masks, from structural designs to integrated functional modules that empower the mask’s ability to sense and transfer physiological or environmental information to become smart. Specifically, we discussed recent developments in masks designed to detect macroscopic physiological signals from the wearer and mask-based disease diagnoses, such as COVID-19. Further, we propose the concept of next-generation smart masks and the requirements from material selection and function design perspectives that enable masks to interact and play crucial roles in health-caring wearables.
    Materialart: Online-Ressource
    ISSN: 2079-6374
    URL: Article
    DOI: 10.3390/bios13020205
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2662125-3
    Standort Signatur Einschränkungen Verfügbarkeit
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