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  • 1
    Online Resource
    Online Resource
    Risk Factors for Hiccups after Deep Brain Stimulation of Subthalamic Nucleus for Parkinson’s Disease
    MDPI AG ; 2022
    In:  Brain Sciences Vol. 12, No. 11 ( 2022-10-26), p. 1447-
    Details
    In: Brain Sciences, MDPI AG, Vol. 12, No. 11 ( 2022-10-26), p. 1447-
    Abstract: Background: After deep brain stimulation (DBS), hiccups as a complication may lead to extreme fatigue, sleep deprivation, or affected prognosis. Currently, the causes and risk factors of postoperative hiccups are unclear. In this study, we investigated the risk factors for hiccups after DBS of the subthalamic nucleus (STN) for Parkinson’s disease (PD) under general anesthesia. Methods: We retrospectively included patients who underwent STN DBS in the study, and collected data of demographic characteristics, clinical evaluations, and medications. According to the occurrence of hiccups within seven days after operation, the patients were divided into a hiccups group and non-hiccups group. The potentially involved risk factors for postoperative hiccups were statistically analyzed by logistic regression analysis. Results: A total of 191 patients were included in the study, of which 34 (17.80%) had postoperative transient persistent hiccups. Binary univariate logistic regression analysis showed that male, higher body mass index (BMI), smoker, Hoehn and Yahr stage (off), preoperative use of amantadine, hypnotic, Hamilton anxiety scale and Hamilton depression scale scores, and postoperative limited noninfectious peri-electrode edema in deep white matter were suspected risk factors for postoperative hiccups (p 〈 0.1). In binary multivariate logistic regression analysis, male (compared to female, OR 14.00; 95% CI, 1.74–112.43), postoperative limited noninfectious peri-electrode edema in deep white matter (OR, 7.63; 95% CI, 1.37–42.37), preoperative use of amantadine (OR, 3.64; 95% CI, 1.08–12.28), and higher BMI (OR, 3.50; 95% CI, 1.46–8.36) were independent risk factors for postoperative hiccups. Conclusions: This study is the first report about the risk factors of hiccups after STN DBS under general anesthesia for PD patients. The study suggests that male, higher BMI, preoperative use of amantadine, and postoperative limited noninfectious peri-electrode edema in deep white matter are independent risk factors for postoperative hiccups of STN-DBS for PD patients. Most hiccups after STN-DBS for PD patients were transient and self-limiting.
    Type of Medium: Online Resource
    ISSN: 2076-3425
    URL: Article
    DOI: 10.3390/brainsci12111447
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2651993-8
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  • 2
    Online Resource
    Online Resource
    New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 2 ( 2023-01-12), p. 1487-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 2 ( 2023-01-12), p. 1487-
    Abstract: Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1–3 all reduce Aβ42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer’s disease [AD] associated with BACE1-, NCSTN-, GSK3β-, and CDK5-mediated pathways, suggesting these alkaloids’ potential against AD.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24021487
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    An Attention Mechanism-Improved YOLOv7 Object Detection Algorithm for Hemp Duck Count Estimation
    MDPI AG ; 2022
    In:  Agriculture Vol. 12, No. 10 ( 2022-10-10), p. 1659-
    Details
    In: Agriculture, MDPI AG, Vol. 12, No. 10 ( 2022-10-10), p. 1659-
    Abstract: Stocking density presents a key factor affecting livestock and poultry production on a large scale as well as animal welfare. However, the current manual counting method used in the hemp duck breeding industry is inefficient, costly in labor, less accurate, and prone to double counting and omission. In this regard, this paper uses deep learning algorithms to achieve real-time monitoring of the number of dense hemp duck flocks and to promote the development of the intelligent farming industry. We constructed a new large-scale hemp duck object detection image dataset, which contains 1500 hemp duck object detection full-body frame labeling and head-only frame labeling. In addition, this paper proposes an improved attention mechanism YOLOv7 algorithm, CBAM-YOLOv7, adding three CBAM modules to the backbone network of YOLOv7 to improve the network’s ability to extract features and introducing SE-YOLOv7 and ECA-YOLOv7 for comparison experiments. The experimental results show that CBAM-YOLOv7 had higher precision, and the recall, mAP@0.5, and mAP@0.5:0.95 were slightly improved. The evaluation index value of CBAM-YOLOv7 improved more than those of SE-YOLOv7 and ECA-YOLOv7. In addition, we also conducted a comparison test between the two labeling methods and found that the head-only labeling method led to the loss of a high volume of feature information, and the full-body frame labeling method demonstrated a better detection effect. The results of the algorithm performance evaluation show that the intelligent hemp duck counting method proposed in this paper is feasible and can promote the development of smart reliable automated duck counting.
    Type of Medium: Online Resource
    ISSN: 2077-0472
    URL: Article
    DOI: 10.3390/agriculture12101659
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2651678-0
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  • 4
    Online Resource
    Online Resource
    Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death against Human Non-Small Cell Lung Cancers
    MDPI AG ; 2020
    In:  International Journal of Molecular Sciences Vol. 21, No. 16 ( 2020-08-05), p. 5608-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 21, No. 16 ( 2020-08-05), p. 5608-
    Abstract: Non-small cell lung cancer (NSCLC) accounts about 80% of all lung cancers. More than two-thirds of NSCLC patients have inoperable, locally advanced or metastatic tumors. Non-toxic agents that synergistically potentiate cancer-killing activities of chemotherapeutic drugs are in high demand. YL-9 was a novel and non-cytotoxic compound with the structure related to sildenafil but showing much less activity against phosphodiesterase type 5 (PDE5). NCI-H460, an NSCLC cell line with low PDE5 expression, was used as the cell model. YL-9 synergistically potentiated vinorelbine-induced anti-proliferative and apoptotic effects in NCI-H460 cells. Vinorelbine induced tubulin acetylation and Bub1-related kinase (BUBR1) phosphorylation, a necessary component in spindle assembly checkpoint. These effects, as well as BUBR1 cleavage, were substantially enhanced in co-treatment with YL-9. Several mitotic arrest signals were enhanced under combinatory treatment of vinorelbine and YL-9, including an increase of mitotic spindle abnormalities, increased cyclin B1 expression, B-cell lymphoma 2 (Bcl-2) phosphorylation and increased phosphoproteins. Moreover, YL-9 also displayed synergistic activity in combining with vinorelbine to induce apoptosis in A549 cells which express PDE5. In conclusion. the data suggest that YL-9 is a novel agent that synergistically amplifies vinorelbine-induced NSCLC apoptosis through activation of spindle assembly checkpoint and increased mitotic arrest of the cell cycle. YL-9 shows the potential for further development in combinatory treatment against NSCLC.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms21165608
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Differences in Gall Induction of Flower-like Galls on Haloxylon by Psyllids (Hemiptera: Aphalaridae), and the Emergence of Corresponding Parasitoids
    MDPI AG ; 2021
    In:  Insects Vol. 12, No. 10 ( 2021-09-23), p. 861-
    Details
    In: Insects, MDPI AG, Vol. 12, No. 10 ( 2021-09-23), p. 861-
    Abstract: Saxaul is a kind of dominant perennial psammophyte that widely distributes in arid and semi-arid desert areas, and it has multiple functions in preventing desertification, especially in windbreak and sand fixation. Various gall inducers induce galls on the saxaul, including the flower-like gall. Parasitoids have great potentiality in controlling gall inducers. However, studies about gall inducers and parasitoids of flower-like galls on Haloxylon, as well as the parasitic efficacy of the parasitoids, are rarely reported. In this study, the flower-like galls were observed on Haloxylon ammodendron and H. persicum in Fukang, Xinjiang, China. Two types of flower-like galls were found on H. ammodendron, while only one type was found on H. persicum. In total, five species of gall inducers and three species of parasitoids were obtained from the galls mentioned above. All the galls were induced by Caillardia (Hemiptera: Aphalaridae), which were mostly bivoltine in Fukang. Besides, their parasitoids Psyllaephaguscaillardiae and P. longiventris could be observed on all the types of galls. Additionally, correlative studies on the parasitization indexes demonstrated that all the dominant parasitoids of diverse flower-like galls were P. caillardiae, which were slightly more in number than the P. ogazae discovered in the flower bud-like galls. In addition, the relevance between the emergence or lifespan of parasitoids and temperature was also investigated. The results showed that the number of parasitoids emerging decreased rapidly after a period of enhancement with the increase of temperature, including an optimum temperature, while the lifespan of wasps gradually shortened with the temperature rising. Our results highlight the importance of the biological investigation of parasitoids in the gall inducers lived in closed galls, which may provide critical evidence for us to understand its potential application in biological control.
    Type of Medium: Online Resource
    ISSN: 2075-4450
    URL: Article
    DOI: 10.3390/insects12100861
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2662247-6
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  • 6
    Online Resource
    Online Resource
    Effective Identification of Terrain Positions from Gridded DEM Data Using Multimodal Classification Integration
    MDPI AG ; 2018
    In:  ISPRS International Journal of Geo-Information Vol. 7, No. 11 ( 2018-11-14), p. 443-
    Details
    In: ISPRS International Journal of Geo-Information, MDPI AG, Vol. 7, No. 11 ( 2018-11-14), p. 443-
    Abstract: Terrain positions are widely used to describe the Earth’s topographic features and play an important role in the studies of landform evolution, soil erosion and hydrological modeling. This work develops a new multimodal classification system with enhanced classification performance by integrating different approaches for terrain position identification. The adopted classification approaches include local terrain attribute (LA)-based and regional terrain attribute (RA)-based, rule-based and supervised, and pixel-based and object-oriented methods. Firstly, a double-level definition scheme is presented for terrain positions. Then, utilizing a hierarchical framework, a multimodal approach is developed by integrating different classification techniques. Finally, an assessment method is established to evaluate the new classification system from different aspects. The experimental results, obtained at a Loess Plateau region in northern China on a 5 m digital elevation model (DEM), show reasonably positional relationship, and larger inter-class and smaller intra-class variances. This indicates that identified terrain positions are consistent with the actual topography from both overall and local perspectives, and have relatively good integrity and rationality. This study demonstrates that the current multimodal classification system, developed by taking advantage of various classification methods, can reflect the geographic meanings and topographic features of terrain positions from different levels.
    Type of Medium: Online Resource
    ISSN: 2220-9964
    URL: Article
    DOI: 10.3390/ijgi7110443
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2655790-3
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  • 7
    Online Resource
    Online Resource
    Applying an Improved Stacking Ensemble Model to Predict the Mortality of ICU Patients with Heart Failure
    MDPI AG ; 2022
    In:  Journal of Clinical Medicine Vol. 11, No. 21 ( 2022-10-31), p. 6460-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 11, No. 21 ( 2022-10-31), p. 6460-
    Abstract: Cardiovascular diseases have been identified as one of the top three causes of death worldwide, with onset and deaths mostly due to heart failure (HF). In ICU, where patients with HF are at increased risk of death and consume significant medical resources, early and accurate prediction of the time of death for patients at high risk of death would enable them to receive appropriate and timely medical care. The data for this study were obtained from the MIMIC-III database, where we collected vital signs and tests for 6699 HF patient during the first 24 h of their first ICU admission. In order to predict the mortality of HF patients in ICUs more precisely, an integrated stacking model is proposed and applied in this paper. In the first stage of dataset classification, the datasets were subjected to first-level classifiers using RF, SVC, KNN, LGBM, Bagging, and Adaboost. Then, the fusion of these six classifier decisions was used to construct and optimize the stacked set of second-level classifiers. The results indicate that our model obtained an accuracy of 95.25% and AUROC of 82.55% in predicting the mortality rate of HF patients, which demonstrates the outstanding capability and efficiency of our method. In addition, the results of this study also revealed that platelets, glucose, and blood urea nitrogen were the clinical features that had the greatest impact on model prediction. The results of this analysis not only improve the understanding of patients’ conditions by healthcare professionals but allow for a more optimal use of healthcare resources.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm11216460
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662592-1
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  • 8
    Online Resource
    Online Resource
    Evaluation of Production–Living–Ecological Functions in Support of SDG Target 11.a: Case Study of the Guangxi Beibu Gulf Urban Agglomeration, China
    MDPI AG ; 2022
    In:  Diversity Vol. 14, No. 6 ( 2022-06-11), p. 469-
    Details
    In: Diversity, MDPI AG, Vol. 14, No. 6 ( 2022-06-11), p. 469-
    Abstract: Sustainable Development Goals (SDGs) target 11.a is a good vision for the coordinated development of the economy, society and environment in urban agglomerations. However, there was an extreme lack of indicators, data or case studies for SDG target 11.a, since it is a vague “process target”, which is not conducive to the implementation of SDG target 11.a. It is important to propose a quantitative, convenient, and local policies relevant method to promote the realization or to test the implementation effects of SDG target 11.a. Combined with socio-economic data and land use data, this study uses the methods of comprehensive evaluation model, coupling and coordination degree, and comparative advantage degree methods to study the pattern evolution, coordination characteristics and advantageous areas of production–living–ecological (PLE) functions in the Guangxi Beibu Gulf Urban Agglomeration (GBG_UA) from 1995 to 2019. The results showed that, (1) considering the spatiotemporal distribution of PLE functions, the study area has a relatively stable ecological function as well as fluctuating production and living functions. Considering the coordination characteristics of PLE functions, high–high and low–low clustering effects were observed, and primary coordination maintained the highest proportion, accounting from 55.26% in 1995 to 71.05% in 2019, indicating the SDG target 11.a level in the GBG_UA was poor. Considering the advantageous areas for PLE functions, the region mostly comprises single-function advantageous areas and a few multifunction advantageous areas, including 20 single-function advantage counties (accounting for 52%), 15 dual-function advantage counties (accounting for 39%), and three multi-function advantage counties (accounting for 7.8%), which indicates the lack of diversified land use structures in this region. (2) Optimization suggestions for the coordinated development and realization of SDG target 11.a for the GBG_UA were provided. Suggestions were made based on the radiation and driving role of Nanning city to guide the coordinated development of surrounding counties (districts). Suggestions were also made to improve the design of the integrated transportation network as well as to optimize allocation according to the resource endowment of land and to realize an upgraded ecology as well as agricultural products and services. (3) The evaluation of PLE functions is a quantitative and convenient method that can optimize national and regional development planning and test the implementation effects of SDG target 11.a. This study offers foundational knowledge for the realization of SDG target 11.a in the GBG_UA and provides a reference for the research and implementation of SDG target 11.a in other regions around the world.
    Type of Medium: Online Resource
    ISSN: 1424-2818
    URL: Article
    DOI: 10.3390/d14060469
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2518137-3
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  • 9
    Online Resource
    Online Resource
    Identification of Non-Electrophilic Nrf2 Activators from Approved Drugs
    MDPI AG ; 2017
    In:  Molecules Vol. 22, No. 6 ( 2017-05-26), p. 883-
    Details
    In: Molecules, MDPI AG, Vol. 22, No. 6 ( 2017-05-26), p. 883-
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules22060883
    Language: English
    Publisher: MDPI AG
    Publication Date: 2017
    detail.hit.zdb_id: 2008644-1
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  • 10
    Online Resource
    Online Resource
    Cloning and Expression Analysis of a PISTILLATA Homologous Gene from Pineapple (Ananas comosus L. Merr)
    MDPI AG ; 2012
    In:  International Journal of Molecular Sciences Vol. 13, No. 1 ( 2012-01-19), p. 1039-1053
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 13, No. 1 ( 2012-01-19), p. 1039-1053
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms13011039
    Language: English
    Publisher: MDPI AG
    Publication Date: 2012
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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