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  • Hindawi Limited  (2)
  • English  (2)
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  • Hindawi Limited  (2)
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  • English  (2)
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  • 1
    In: Complexity, Hindawi Limited, Vol. 2021 ( 2021-12-8), p. 1-12
    Abstract: The number of intelligent applications available for IIoT environments is growing, but when the time-series data these applications rely on are incomplete, their performance suffers. Unfortunately, incomplete data are all too frequent to a phenomenon in the world of IIoT. A common workaround is to use imputation. However, the current methods are largely designed to reconstruct a single missing pattern, where a robust and flexible imputation framework would be able to handle many different missing patterns. Hence, the framework presented in this study, RAEF, is capable of processing multiple missing patterns. Based on a recurrent autoencoder, RAEF houses a novel neuron structure, called a gated regulator, which reduces the negative impact of different missing patterns. In a comparison of the state-of-the-art time-series imputation frameworks at a range of different missing rates, RAEF yielded fewer errors than all its counterparts.
    Type of Medium: Online Resource
    ISSN: 1099-0526 , 1076-2787
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 2
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: Zearalenone is a mycotoxin produced by Fusarium spp. 11 β -Hydroxysteroid dehydrogenases, isoforms 1 (HSD11B1) and 2 (HSD11B2), have been demonstrated to be the regulators of the local level of active glucocorticoid, which has a broad range of physiological actions. In the present study, the potency of zearalenone was tested for the inhibition of HSD11B1 and HSD11B2 in rat and human tissues. Zearalenone showed potent inhibition of HSD11B2 with the half-maximal inhibitory concentration (IC 50 ) calculated at 49.63 and 32.22  μ M for the rat and human, respectively. Results showed that zearalenone competitively inhibited HSD11B2 when a steroid substrate was used. However, it served as an uncompetitive inhibitory factor when the cofactor NAD + was used. In contrast, the potency of zearalenone to inhibit both rat and human HSD11B1 was diminished, with the concentration of 100  μ M causing almost no inhibitory effect on the isoform. In conclusion, we observed that zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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