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  • Hindawi Limited  (3)
  • English  (3)
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  • Hindawi Limited  (3)
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  • English  (3)
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  • 1
    Online Resource
    Online Resource
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-8-24), p. 1-17
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-8-24), p. 1-17
    Abstract: Background. SPTSSA encodes the small subunit A of serine palmitoyltransferase. It catalyzes the formation of sphingoid long-chain base backbone of sphingolipids. Its role in glioma prognosis and tumor-infiltrating immune cells remains unclear. Methods. We analyzed SPTSSA expression and association with clinical prognosis using GEPIA and CGGA database. Then, GSEA was performed to identify relevant biological functions of SPTSSA. The correlations between SPTSSA expression and tumor immune infiltrates were investigated using CIBERSORT and TIMER. Finally, IHC and IF were performed to confirm the value of prognosis and the correlation with immune infiltration. Results. SPTSSA expression was significantly upregulated in diffuse glioma compared to normal tissues and associated with poor survival in GEPIA and CGGA database. Then, we identified biological processes and signaling pathways associated with SPTSSA expression. The result showed that SPTSSA enriched in the GO term like oxidative stress. Finally, we showed that SPTSSA expression was significantly associated with tumor-infiltrating immune cells and overall survival via IHC. Conclusion. These findings suggest that SPTSSA expression might be used as a prognostic biomarker for glioma and potential target for novel glioma therapy.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 2
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  Advances in Civil Engineering Vol. 2021 ( 2021-4-9), p. 1-9
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2021 ( 2021-4-9), p. 1-9
    Abstract: Adopting an effective top coal caving method is the key to enhancing coal recovery and reducing gangue content for the fully mechanized top coal caving working face with extra-thick coal seams. In this study, the movement of coal particles generated during top coal caving is considered to follow a normal distribution. Then, the caving body and coal-rock settlement along the working face during the caving process are studied based on both the random media theory and probability theory. Accordingly, the optimal caving interval and caving sequences are determined, and a novel interval symmetrical coal caving method is proposed. The proposed method is systematically verified with results from physical similarity tests, and different caving methods are assessed by field tests. The results show the following: (1) The coal-rock settlement and the caving body demonstrate clear axial symmetrical features along the working face; the size of the caving body increases as the caving height grows and its shape turns progressively from semicircular to semielliptical with a lower foot of the coal-rock settlement. (2) The caving interval is derived using the sum of the radii of the coal-rock settlement curves formed by the two largest caving bodies. (3) The symmetrical caving approach provides a symmetrical space for the subsequent movement of the broken top coal, which enables a uniform development of the caving body. (4) Compared with the traditional sequential coal caving method with the same number of supports, the interval symmetrical caving method results in a 21.7% of coal production increase, 17% caving rate promotion, and a shortened caving time by 23.4%. (5) The interval symmetrical caving method is found to improve the controllability of the caving process at the fully mechanized top coal caving working face. In general, this work presents a theoretical approach to select the optimal caving methods for the fully mechanized caving working face in extra-thick coal seams for an improved production efficiency of the work face. The results of this study can also provide theoretical significance and referencing value for quantitative analyses of the coal caving methods for work faces with similar geological conditions.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2449760-5
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  • 3
    Online Resource
    Online Resource
    Hindawi Limited ; 2007
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 17, No. 2 ( 2007-03), p. 123-133
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 17, No. 2 ( 2007-03), p. 123-133
    Type of Medium: Online Resource
    ISSN: 1096-4290 , 1099-047X
    URL: Issue
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2007
    detail.hit.zdb_id: 2007326-4
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