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  • 1
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    Online Resource
    Molecular and morphological data place Blarneya in Tylophoron ( Arthoniaceae )
    Cambridge University Press (CUP) ; 2011
    In:  The Lichenologist Vol. 43, No. 4 ( 2011-07), p. 345-356
    Details
    In: The Lichenologist, Cambridge University Press (CUP), Vol. 43, No. 4 ( 2011-07), p. 345-356
    Abstract: Based on morphological, anatomical, chemical, ecological and molecular evidence, Blarneya is synonymized here with Tylophoron . The molecular phylogeny derived from sequences obtained from sporodochia of Blarneya places this genus, described to accommodate an anamorphic lichen with white cushion-shaped sporodochia, within Tylophoron . This conclusion is further supported by the discovery of Tylophoron -type ascomata emerging directly from thalli with Blarneya -type sporodochia and producing identical hyaline conidia. In one specimen pycnidia were also observed. This represents a surprising variety of morphologically different conidiomata. A different anamorphic type was previously reported from Tylophoron , and this is confirmed here by molecular analysis for T. moderatum : besides thalli with ascomata this species has anamorphic thalli with an irregularly delimited brown sporodochial felt and brown conidia. Ascomata are not known from these entirely anamorphic thalli, whereas they do occur infrequently in Tylophoron species with Blarneya -type sporodochia. A key to all currently accepted species of Tylophoron is provided. In addition to the corticolous Tylophoron hibernicum , confined to humid forests, two saxicolous species with Blarneya -type sporodochia are described here as new: T. galapagoense , known only from Galapagos, differs from T. hibernicum by a thicker, more compact, beige rather than white, more strongly C+ red thallus, growing below sheltered rock overhangs in dry forests; T. stalactiticum has a C− thallus with stipitate, white, C+ red sporodochia; the species is known only from a single locality in Tenerife, on a large slope with volcanic boulders.
    Type of Medium: Online Resource
    ISSN: 0024-2829 , 1096-1135
    URL: Article
    DOI: 10.1017/S002428291100020X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2011
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  • 2
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    Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides
    Cambridge University Press (CUP) ; 2009
    In:  Expert Reviews in Molecular Medicine Vol. 11 ( 2009-03)
    Details
    In: Expert Reviews in Molecular Medicine, Cambridge University Press (CUP), Vol. 11 ( 2009-03)
    Abstract: Antisense oligonucleotides as a therapeutic platform have been slow to progress since the approval of the first antisense drug in 1998. Recently, there have been several examples of convincing antisense interventions in animal models and promising clinical trial data. This review considers the factors determining the success of antisense oligonucleotides as therapeutic agents. In order to produce target knockdown after systemic delivery, antisense oligonucleotides must avoid nuclease degradation, reticuloendothelial-system uptake and rapid renal excretion, and extravasate to the target cell type outside the vasculature. They then must enter the target cell, and escape the endosome–lysosome pathway so as to be free to interact with the target mRNA. We consider the significance of these limiting factors based on the literature and our own experience using systemic administration of antisense oligonucleotides.
    Type of Medium: Online Resource
    ISSN: 1462-3994
    URL: Article
    DOI: 10.1017/S1462399409001021
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2009
    detail.hit.zdb_id: 2035515-4
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  • 3
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    Older people and falls: a randomized controlled trial of a health visitor (HV) intervention
    Cambridge University Press (CUP) ; 2001
    In:  Reviews in Clinical Gerontology Vol. 11, No. 3 ( 2001-08), p. 209-214
    Details
    In: Reviews in Clinical Gerontology, Cambridge University Press (CUP), Vol. 11, No. 3 ( 2001-08), p. 209-214
    Abstract: Research shows that approximately one in three people over the age of 65 years falls in any one year, with approximately one in three falling again in the following year. Prevalence of falls also increases with age, and women are more likely to fall than men. However, in advanced old age the ratio of men and women fallers reaches equal proportions.
    Type of Medium: Online Resource
    ISSN: 0959-2598 , 1469-9036
    URL: Article
    DOI: 10.1017/S0959259801011327
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2001
    detail.hit.zdb_id: 2000041-8
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  • 4
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    The effect of feeding structured triacylglycerols enriched in eicosapentaenoic or docosahexaenoic acids on murine splenocyte fatty acid composition and leucocyte phagocytosis
    Cambridge University Press (CUP) ; 2003
    In:  British Journal of Nutrition Vol. 90, No. 6 ( 2003-12), p. 1071-1080
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 90, No. 6 ( 2003-12), p. 1071-1080
    Abstract: The effects of altering the type of n -3 polyunsaturated fatty acid (PUFA) in the mouse diet on the ability of monocytes and neutrophils to perform phagocytosis were investigated. Male weanling mice were fed for 7 d on one of nine diets which contained 178 g lipid/kg and which differed in the type of n -3 PUFA and in the position of these in dietary triacylglycerol (TAG). The control diet contained 4·4 g α-linolenic acid/100 g total fatty acids. In the other diets, eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) replaced a proportion (50 or 100 %) of the α-linolenic acid, and were in the sn -2 or the sn -1(3) position of dietary TAG. There were significant increases in the content of n -3 PUFA in spleen-cell phospholipids when EPA or DHA was fed. These increases were largely independent of the position of EPA or DHA in dietary TAG except when EPA was fed at the highest level, when the incorporation was greater when it was fed in the sn -2 than in the sn -1(3) position. There was no significant effect of dietary DHA on monocyte or neutrophil phagocytic activity. Dietary EPA dose-dependently decreased the number of monocytes and neutrophils performing phagocytosis. However, when EPA was fed in the sn -2 position, the ability of active monocytes or neutrophils to engulf bacteria was increased in a dose-dependent fashion. This did not occur when EPA was fed in the sn -1(3) position. Thus, there appears to be an influence of the position of EPA, but not of DHA, in dietary TAG on its incorporation into cell phospholipids and on the activity of phagocytic cells.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1079/BJN2003996
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
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    SSG: 21
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  • 5
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    No major differences in energy metabolism between matched and unmatched groups of ‘large-eating’ and ‘small-eating’ men
    Cambridge University Press (CUP) ; 1993
    In:  British Journal of Nutrition Vol. 70, No. 2 ( 1993-09), p. 393-406
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 70, No. 2 ( 1993-09), p. 393-406
    Abstract: Rates of energy expenditure (J/kg fat-free mass (FFM) per min) in normal weight, ‘small-eating’ men were compared with those obtained for normal weight ( n 8) and underweight ( n 5) ‘large-eating’ men. For the matched groups of ‘large-’ and ‘small-eaters’ there were no differences in resting metabolic rate (RMR) measurements but during controlled daily activities there was a small but significant increase ( P 〈 0.05) in energy expenditure in the ‘large-eaters’. These results contrast with those obtained for the unmatched groups where energy requirements were about 10 % ( P 〈 0.01) higher in the underweight ‘large-eaters’ at rest but were not different during the more energetic (walking) activities. However, after adjustment for differences in FFM between these two groups, the resting energy expenditures of the ‘large-eaters’ (82·54 (SE 1·51) J/kg FFM per min) were similar to those of the ‘small-eaters’ (81·87 (SE 1·51) J/kg FFM per min). Oral temperatures were significantly higher in the matched (0·35–0·65°) and unmatched (0·7–0·9°) ‘large-eaters’ both at rest and during the different activities, but the thermic effect of food (50 kJ/kg FFM) was one fifth lower (not significant) in both groups of ‘large-eaters’. These results provide little evidence for any major metabolic differences between groups of ‘large-eating’ and ‘small-eating’ men.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1079/BJN19930134
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1993
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  • 6
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    The Southern 2MASS Active Galactic Nuclei Survey: Spectroscopic Follow-up with Six Degree Field
    Cambridge University Press (CUP) ; 2010
    In:  Publications of the Astronomical Society of Australia Vol. 27, No. 3 ( 2010), p. 302-320
    Details
    In: Publications of the Astronomical Society of Australia, Cambridge University Press (CUP), Vol. 27, No. 3 ( 2010), p. 302-320
    Abstract: The Two Micron All-Sky Survey (2MASS) has provided a uniform photometric catalog to search for previously unknown red active galactic nuclei (AGN) and Quasi-Stellar Objects (QSOs).We have extended the search to the southern equatorial sky by obtaining spectra for 1182 AGN candidates using the six degree field (6dF) multifibre spectrograph on the UK Schmidt Telescope. These were scheduled as auxiliary targets for the 6dF Galaxy Redshift Survey. The candidates were selected using a single color cut of J – K s 〉 2 to K s ≲ 15.5 and a galactic latitude of lbl 〉 30°. 432 spectra were of sufficient quality to enable a reliable classification. 116 sources (∼27%) were securely classified as type I AGN, 20 as probable type I AGN, and 57 as probable type II AGN. Most of them span the redshift range 0.05 〈 z 〈 0.5 and only 8 (∼6%) were previously identified as AGN or QSOs. Our selection leads to a significantly higher AGN identification rate amongst local galaxies ( 〉 20%) than in any previous (mostly blue-selected) galaxy survey. A small fraction of the type I AGN could have their optical colors reddened by optically thin dust with A V 〈 2 mag relative to optically selected QSOs. A handful show evidence of excess far-infrared (IR) emission. The equivalent width (EW) and color distributions of the type I and II AGN are consistent with AGN unified models. In particular, the EW of the [O iii ] emission line weakly correlates with optical–near-IR color in each class of AGN, suggesting anisotropic obscuration of the AGN continuum. Overall, the optical properties of the 2MASS red AGN are not dramatically different from those of optically-selected QSOs. Our near-IR selection appears to detect the most near-IR luminous QSOs in the local universe to z ≃0.6 and provides incentive to extend the search to deeper near-IR surveys.
    Type of Medium: Online Resource
    ISSN: 1323-3580 , 1448-6083
    URL: Article
    DOI: 10.1071/AS10001
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2010
    detail.hit.zdb_id: 2560489-2
    detail.hit.zdb_id: 2079225-6
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  • 7
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    Lessons from the English auxiliary system - CORRIGENDUM
    Cambridge University Press (CUP) ; 2020
    In:  Journal of Linguistics Vol. 56, No. 1 ( 2020-02-01), p. 227-228
    Details
    In: Journal of Linguistics, Cambridge University Press (CUP), Vol. 56, No. 1 ( 2020-02-01), p. 227-228
    Type of Medium: Online Resource
    ISSN: 0022-2267 , 1469-7742
    URL: Article
    DOI: 10.1017/S0022226719000094
    RVK:
    EQ 1000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2020
    detail.hit.zdb_id: 3073-9
    detail.hit.zdb_id: 1466491-4
    SSG: 7,11
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  • 8
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    Language Varieties and Genres - Michael R. Walrod, Discourse grammar in Ga'dang. (Summer Institute of Linguistics Publications in Linguistics, 63.) Dallas: The Summer Institute of Linguistics and the University of Texas at Arlington, 1979. Pp. 116.
    Cambridge University Press (CUP) ; 1982
    In:  Language in Society Vol. 11, No. 1 ( 1982-04), p. 145-147
    Details
    In: Language in Society, Cambridge University Press (CUP), Vol. 11, No. 1 ( 1982-04), p. 145-147
    Type of Medium: Online Resource
    ISSN: 0047-4045 , 1469-8013
    URL: Article
    DOI: 10.1017/S0047404500009131
    RVK:
    EQ 1000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1982
    detail.hit.zdb_id: 1492118-2
    detail.hit.zdb_id: 121434-2
    SSG: 7,11
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  • 9
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    Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses
    Cambridge University Press (CUP) ; 2021
    In:  Parasitology Vol. 148, No. 4 ( 2021-04), p. 408-419
    Details
    In: Parasitology, Cambridge University Press (CUP), Vol. 148, No. 4 ( 2021-04), p. 408-419
    Abstract: A prior systematic review on the efficacy of halofuginone (HFG) treatment to prevent or treat cryptosporidiosis in bovine calves was inconclusive. We undertook an updated synthesis and meta-analyses on key outcomes for the treatment of calves with HFG. Evaluated outcomes were oocyst shedding, diarrhoea, mortality and weight gain. Experiments had to describe results for same age animals in contemporary arms. Most doses were 100–150 mcg kg −1 day −1 . Results were subgrouped by study design, experiments with the lowest risk of bias and lack of industry funding. Eighteen articles were found that described 25 experiments. Most evidence came from randomized controlled trials in Europe. Significantly lower incidence of oocyst shedding, diarrhoea burden and mortality was reported when treatment started before calves were 5 days old. Most studies reported on outcomes for animals up to at least 28 days old. Publication bias was possible in all outcomes and seemed especially likely for diarrhoea outcomes. Beneficial results when HFG treatment was initiated in calves older than 5 days were also found. Prophylactic treatment to prevent cryptosporidiosis is effective in preventing multiple negative outcomes and is beneficial to calf health and will result in a reduction of environmental contamination by Cryptosporidium oocysts.
    Type of Medium: Online Resource
    ISSN: 0031-1820 , 1469-8161
    URL: Article
    DOI: 10.1017/S0031182020002267
    RVK:
    WA 15000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 1491287-9
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  • 10
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    FINITE-SAMPLE INSTRUMENTAL VARIABLES INFERENCE USING AN ASYMPTOTICALLY PIVOTAL STATISTIC
    Cambridge University Press (CUP) ; 2003
    In:  Econometric Theory Vol. 19, No. 05 ( 2003-10)
    Details
    In: Econometric Theory, Cambridge University Press (CUP), Vol. 19, No. 05 ( 2003-10)
    Type of Medium: Online Resource
    ISSN: 0266-4666 , 1469-4360
    URL: Article
    DOI: 10.1017/S0266466603195023
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 1501041-7
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