In:
Current Neuropharmacology, Bentham Science Publishers Ltd., Vol. 19, No. 11 ( 2021-11), p. 1855-1864
Abstract:
Epilepsy represents one of the most common brain diseases among humans.
Tissue acidosis is a common phenomenon in epileptogenic foci. Moreover, its role in epileptogenesis remains unclear. Acid-sensing ion channel-1a (ASIC1a) represents a potential way to
assess new therapies. ASIC1a, mainly expressed in the mammalian brain, is a type of protein-gated cation channel. It has been shown to play an important role in the pathological mechanism of various
diseases, including stroke, epilepsy, and multiple sclerosis. Methods: Data were collected from Web of Science, Medline, PubMed, through searching for these
keywords: "Acid-sensing ion channels 1a" or "ASIC1a" and "epilepsy" or "seizure". Results: The role of ASIC1a in epilepsy remains controversial; it may represent a promising therapeutic
target of epilepsy. Conclusion: This review is intended to provide an overview of the structure, trafficking, and molecular
mechanisms of ASIC1a in order to elucidate the role of ASIC1a in epilepsy further.
Type of Medium:
Online Resource
ISSN:
1570-159X
DOI:
10.2174/1570159X19666210402102232
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
detail.hit.zdb_id:
2119376-9
Permalink
