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  • American Association for Cancer Research (AACR)  (2)
  • English  (2)
  • 1
    Online Resource
    Online Resource
    Abstract 193: Adipocytes, obesity and the multiple myeloma microenvironment
    American Association for Cancer Research (AACR) ; 2014
    In:  Cancer Research Vol. 74, No. 19_Supplement ( 2014-10-01), p. 193-193
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 74, No. 19_Supplement ( 2014-10-01), p. 193-193
    Abstract: Multiple myeloma (MM), a hematological malignancy characterized by monoclonal plasma cells in the bone marrow, affects nearly 23,000 Americans per year. Obesity contributes to the development and progression of multiple myeloma, yet the relationship between MM cells and adipocytes found in the tumor microenvironment has not been fully elucidated. To examine how adipocytes contribute to the growth and progression of MM, we co-cultured human myeloma cell lines with primary human adipocytes isolated from lipoaspirates. We found that MM cells directly co-cultured with adipocytes or exposed to their conditioned media had increased viability, angiogenic potential, invasion, colony formation, and production of inflammatory cytokines, when compared to MM cells alone. Moreover, adipocytes from obese individuals (BMI & gt; 30) further compounded this. Thus, we demonstrate an important role for adipocytes in promoting myeloma pathologies. Citation Format: Gervaise H. Henry, Nicholas J. Watson, Rebecca C. O'Neill, Tracy Tabib, Erika M. Bullwinkle, Kathleen L. DeCicco-Skinner. Adipocytes, obesity and the multiple myeloma microenvironment. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 193. doi:10.1158/1538-7445.AM2014-193
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2014-193
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2014
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  • 2
    Online Resource
    Online Resource
    The Impact of Exclusive Use of Very Low Nicotine Cigarettes on Compensatory Smoking: An Inpatient Crossover Clinical Trial
    American Association for Cancer Research (AACR) ; 2020
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 29, No. 4 ( 2020-04-01), p. 880-886
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 4 ( 2020-04-01), p. 880-886
    Abstract: The FDA is considering a mandated reduction in the nicotine content of cigarettes. Clinical trials have been limited by non-study cigarette use (noncompliance), which could mask compensation. The goal of this study was to assess whether compensation occurs when smokers provided with very low nicotine cigarettes cannot access normal nicotine cigarettes. Methods: In a within-subjects, crossover design, current smokers (n = 16) were confined to a hotel for two 4-night hotel stays during which they were only able to access the research cigarettes provided. The hotel stays offered normal nicotine cigarettes or very low nicotine content (VLNC) cigarettes, in an unblinded design, available for “purchase” via a study bank. Results: In the context of complete compliance with the study cigarettes (n = 16), there was not a significant increase during the VLNC condition for cigarettes smoked per day, expired carbon monoxide, or N-acetyl-S-(cyanoethyl)-l-cysteine (cyanoethyl-MA, metabolite of acrylonitrile). There was a significant nicotine × time interaction on urine N-acetyl-S-(3-hydroxypropyl)-l-cysteine (hydroxypropyl-MA, metabolite of acrolein), driven by an increase in the VLNC condition during the first 24 hours. By the end of the VLNC condition, there was no evidence of compensation across any measure of smoking or smoke exposure. Conclusions: Among current smokers who exclusively used VLNC cigarettes for 4 days, there was no significant compensatory smoking behavior. Impact: These data, combined with the larger body of work, suggest that a mandated reduction in nicotine content is unlikely to result in an increase in smoking behavior to obtain more nicotine.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-19-0963
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
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