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  • 1
    Online Resource
    Online Resource
    participating in a couples therapy outcome study: Participants' views
    Springer Science and Business Media LLC ; 1996
    In:  Contemporary Family Therapy Vol. 18, No. 4 ( 1996-12), p. 607-617
    Details
    In: Contemporary Family Therapy, Springer Science and Business Media LLC, Vol. 18, No. 4 ( 1996-12), p. 607-617
    Type of Medium: Online Resource
    ISSN: 0892-2764 , 1573-3335
    URL: Article
    DOI: 10.1007/BF02195720
    RVK:
    CL 1000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1996
    detail.hit.zdb_id: 2015091-X
    SSG: 2,1
    SSG: 5,2
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  • 2
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    A Unique Academic Committee on Native American Psychiatry
    Springer Science and Business Media LLC ; 1999
    In:  Academic Psychiatry Vol. 23, No. 4 ( 1999-12), p. 222-223
    Details
    In: Academic Psychiatry, Springer Science and Business Media LLC, Vol. 23, No. 4 ( 1999-12), p. 222-223
    Type of Medium: Online Resource
    ISSN: 1042-9670 , 1545-7230
    URL: Article
    DOI: 10.1007/BF03340058
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1999
    detail.hit.zdb_id: 1475666-3
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  • 3
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    Binaural sound reproduction in a stereo dipole system
    Acoustical Society of America (ASA) ; 1996
    In:  The Journal of the Acoustical Society of America Vol. 100, No. 4_Supplement ( 1996-10-01), p. 2700-2700
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 100, No. 4_Supplement ( 1996-10-01), p. 2700-2700
    Abstract: A new transaural system referred to as a ‘‘stereo dipole’’ reproduction system using a closely spaced pair of loudspeakers in front of a listener has been introduced recently. Computer simulations using theoretical models, in which the listener’s head is assumed to be a perfectly rigid sphere, revealed that sound field equalization by the SD system including inverse filtering and also for the virtual source reproduction can be achieved in a wide range of area relative to the standard loudspeaker arrangements. This paper will deal with a further investigation of the SD system in terms of the controlled acoustic field around the head. The theoretical model used in the computer simulation is extended so that one can calculate an impulse response at any point while considering the influence of a rigid sphere. This model is used to compare the sound field around the spherical obstacle due to the SD system with one by the ordinary transaural system.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.417079
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1996
    detail.hit.zdb_id: 1461063-2
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  • 4
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    A Phase I/II Study of the Protease Inhibitor Indinavir in Children With HIV Infection
    American Academy of Pediatrics (AAP) ; 1998
    In:  Pediatrics Vol. 102, No. 1 ( 1998-07-01), p. 101-109
    Details
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 102, No. 1 ( 1998-07-01), p. 101-109
    Abstract: Background. Indinavir, an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease, is approved for the treatment of HIV infection in adults when antiretroviral therapy is indicated. We evaluated the safety and pharmacokinetic profile of the indinavir free-base liquid suspension and the sulfate salt dry-filled capsules in HIV-infected children, and studied its preliminary antiviral and clinical activity in this patient population. In addition, we evaluated the pharmacokinetic profile of a jet-milled suspension after a single dose. Methods. Previously untreated children or patients with progressive HIV disease despite antiretroviral therapy or with treatment-associated toxicity were eligible for this phase I/II study. Three dose levels (250 mg/m2, 350 mg/m2, and 500 mg/m2 per dose given orally every 8 h) were evaluated in 2 age groups ( & lt;12 years and ≥12 years). Indinavir was initially administered as monotherapy and then in combination with zidovudine and lamivudine after 16 weeks. Results. Fifty-four HIV-infected children (ages 3.1 to 18.9 years) were enrolled. The indinavir free-base suspension was less bioavailable than the dry-filled capsule formulation, and therapy was changed to capsules in all children. Hematuria was the most common side effect, occurring in 7 (13%) children, and associated with nephrolithiasis in 1 patient. The combination of indinavir, lamivudine, and zidovudine was well tolerated. The median CD4 cell count increased after 2 weeks of indinavir monotherapy by 64 cells/mm3, and this was sustained at all dose levels. Plasma ribonucleic acid levels decreased rapidly in a dose-dependent way, but increased toward baseline after a few weeks of indinavir monotherapy. Conclusions. Indinavir dry-filled capsules are relatively well tolerated by children with HIV infection, although hematuria occurs at higher doses. Future studies need to evaluate the efficacy of indinavir when combined de novo with zidovudine and lamivudine.
    Type of Medium: Online Resource
    ISSN: 1098-4275 , 0031-4005
    URL: Article
    DOI: 10.1542/peds.102.1.101
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 1998
    detail.hit.zdb_id: 1477004-0
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  • 5
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    Immunoreconstitution after ritonavir therapy in children with human immunodeficiency virus infection involves multiple lymphocyte lineages
    Elsevier BV ; 1999
    In:  The Journal of Pediatrics Vol. 134, No. 5 ( 1999-5), p. 597-606
    Details
    In: The Journal of Pediatrics, Elsevier BV, Vol. 134, No. 5 ( 1999-5), p. 597-606
    Type of Medium: Online Resource
    ISSN: 0022-3476
    URL: Article
    DOI: 10.1016/S0022-3476(99)70247-7
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1999
    detail.hit.zdb_id: 2005245-5
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  • 6
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    Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli
    Rockefeller University Press ; 1996
    In:  The Journal of Experimental Medicine Vol. 184, No. 6 ( 1996-12-01), p. 2429-2432
    Details
    In: The Journal of Experimental Medicine, Rockefeller University Press, Vol. 184, No. 6 ( 1996-12-01), p. 2429-2432
    Abstract: A key rate-limiting step in the adaptive immune response at peripheral challenge sites is the transmission of antigen signals to T cells in regional lymph nodes. Recent evidence suggests that specialized dendritic cells (DC) fulfill this surveillance function in the resting state, but their relatively slow turnover in most peripheral tissues brings into question their effectiveness in signaling the arrival of highly pathogenic sources of antigen which require immediate mobilization of the full range of host defenses for maintenance of homeostasis. However, the present report demonstrates that recruitment of a wave of DC into the respiratory tract mucosa is a universal feature of the acute cellular response to local challenge with bacterial, viral, and soluble protein antigens. Consistent with this finding, we also demonstrate that freshly isolated respiratory mucosal DC respond in vitro to a variety of CC chemokines as well as complementary cleavage products and N-formyl-methionyl-leucine-phenylalanine. This suggests that rapid amplification of specific antigen surveillance at peripheral challenge sites is an integral feature of the innate immune response at mucosal surfaces, and serves as an “early warning system” to alert the adaptive immune system to incoming pathogens.
    Type of Medium: Online Resource
    ISSN: 0022-1007 , 1540-9538
    URL: Article
    DOI: 10.1084/jem.184.6.2429
    RVK:
    XA 10000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 1996
    detail.hit.zdb_id: 1477240-1
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  • 7
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    The automatic control of boundary-layer transition ? Experiments and computation
    Springer Science and Business Media LLC ; 1995
    In:  Applied Scientific Research Vol. 54, No. 4 ( 1995-6), p. 293-311
    Details
    In: Applied Scientific Research, Springer Science and Business Media LLC, Vol. 54, No. 4 ( 1995-6), p. 293-311
    Type of Medium: Online Resource
    ISSN: 0003-6994 , 1573-1987
    URL: Article
    DOI: 10.1007/BF00863515
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1995
    detail.hit.zdb_id: 1492282-4
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  • 8
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    A multiple microphone recording technique for the generation of virtual acoustic images
    Acoustical Society of America (ASA) ; 1999
    In:  The Journal of the Acoustical Society of America Vol. 105, No. 3 ( 1999-03-01), p. 1503-1516
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 105, No. 3 ( 1999-03-01), p. 1503-1516
    Abstract: A new recording technique based on multichannel digital signal processing is suggested. The system uses a dummy-head that is modeled as a rigid sphere with two pairs of microphones mounted on opposite sides of the sphere in the horizontal plane. Reversals—front back confusion, is a well-known phenomenon when localizing virtual acoustic images produced by either headphones or loudspeakers. Reproduction with two loudspeakers to the front of the listener causes rear virtual acoustic images to be perceived primarily at “mirrored” angles in the frontal hemisphere. The problem is tackled here by using a multichannel signal processing technique rather than by mimicking accurately the acoustomechanical properties of a human head. The acoustic signals which are recorded at the microphones are filtered by a 4×4 matrix of digital filters before being transmitted via four loudspeakers. The performance of the system is investigated by means of computer simulations, objective measurements, and also by subjective experiments in an anechoic environment, where the listeners are asked to localize the perceived angle of the signals which were prerecorded with the sphere dummy-head. Successful discrimination of reversals is achieved primarily due to the dominant role of the interaural time delay (ITD) for localization at low frequencies, but the accuracy with which listeners can localize virtual acoustic images is reduced in comparison to a conventional two-ear dummy-head (e.g., KEMAR) with a two-loudspeaker arrangement. The system is robust with respect to head rotations—virtual acoustic images do not disappear and localization ability improves when listeners use small head rotations.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.426690
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1999
    detail.hit.zdb_id: 1461063-2
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  • 9
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    Online Resource
    Local sound field reproduction using two closely spaced loudspeakers
    Acoustical Society of America (ASA) ; 1998
    In:  The Journal of the Acoustical Society of America Vol. 104, No. 4 ( 1998-10-01), p. 1973-1981
    Details
    In: The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 104, No. 4 ( 1998-10-01), p. 1973-1981
    Abstract: When only two loudspeakers are used for the reproduction of sound for a single listener, time domain simulations show that it is advantageous that the two loudspeakers are very close together. The sound field reproduced by two loudspeakers that span 10 degrees as seen by the listener is simpler, and locally more similar to the sound field generated by a real sound source, than that reproduced by two loudspeakers that span 60 degrees. The basic physics of the problem is first explained by assuming that the sound propagates under free-field conditions. It is then demonstrated that when the influence of the listener on the incident sound waves is taken into account by modeling the listener’s head as a rigid sphere, the results are qualitatively the same as in the free-field case. Consequently, two closely spaced loudspeakers are capable of accurately reproducing a desired sound field, not only at the ears of the listener but also in the vicinity of the listener’s head. This result, although counter-intuitive, is very encouraging. In particular, it suggests that many low-fidelity audio systems, such as those currently supplied with most multi-media computers, can be greatly improved.
    Type of Medium: Online Resource
    ISSN: 0001-4966 , 1520-8524
    URL: Article
    DOI: 10.1121/1.423763
    RVK:
    EQ 1000
    Language: English
    Publisher: Acoustical Society of America (ASA)
    Publication Date: 1998
    detail.hit.zdb_id: 1461063-2
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  • 10
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    Online Resource
    A Phase I/II Study of the Protease Inhibitor Ritonavir in Children With Human Immunodeficiency Virus Infection
    American Academy of Pediatrics (AAP) ; 1998
    In:  Pediatrics Vol. 101, No. 3 ( 1998-03-01), p. 335-343
    Details
    In: Pediatrics, American Academy of Pediatrics (AAP), Vol. 101, No. 3 ( 1998-03-01), p. 335-343
    Abstract: Background. Ritonavir, a potent antiretroviral protease inhibitor, has been approved for the treatment of adults and children with human immunodeficiency virus (HIV) infection. In a phase I/II study, we assessed the safety, tolerability, and pharmacokinetic profile of the oral solution of ritonavir in HIV-infected children and studied the preliminary antiviral and clinical effects. Methods. HIV-infected children between 6 months and 18 years of age were eligible. Four dose levels of ritonavir oral solution (250, 300, 350, and 400 mg/m2 given every 12 hours) were evaluated in two age groups (≤2 years, & gt;2 years). Ritonavir was administered alone for the first 12 weeks and then in combination with zidovudine and/or didanosine. Clinical and laboratory parameters were monitored every 2 to 4 weeks. Results. A total of 48 children (median age, 7.7 years; range, 0.5 to 14.4 years) were included in this analysis. Dose-related nausea, diarrhea, and abdominal pain were the most common toxicities and resulted in discontinuation of ritonavir in 7 children. Ritonavir was well absorbed at all dose levels, and plasma concentrations reached a peak 2 to 4 hours after a dose. CD4 cells counts increased by a median of 79 cells/mm3 after 4 weeks of monotherapy and were maintained throughout the study. Plasma HIV RNA decreased by 1 to 2 log10 copies/mL within 4 to 8 weeks of ritonavir monotherapy, and this level was sustained in patients enrolled at the highest dose level of 400 mg/m2 for the 24-week period. Conclusions. The oral solution of ritonavir has potent antiretroviral activity as a single agent and is relatively well tolerated by children when administered alone or in combination with zidovudine or didanosine.
    Type of Medium: Online Resource
    ISSN: 1098-4275 , 0031-4005
    URL: Article
    DOI: 10.1542/peds.101.3.335
    Language: English
    Publisher: American Academy of Pediatrics (AAP)
    Publication Date: 1998
    detail.hit.zdb_id: 1477004-0
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