In:
Journal of Biological Systems, World Scientific Pub Co Pte Ltd, Vol. 03, No. 01 ( 1995-03), p. 155-164
Abstract:
Membrane carries (symporters) performing active transport of solutes are molecular machines which transduce the energy stored in the electrochemical gradient of certain ions into osmotical work. Evolutionary strategies have been used to find optimal catalytic states of different kinetic models of membrane carriers. The analysis shows that in many cases there are several nearly optimal solutions to a given quality function. In general, this is because dissociation constants compensate for rate constants and because the maxima of the quality functions are usually flat with respect to at least some parameters. The number of solutions increases with increasing model complexity. The advantage of kinetic complexity with respect to protein evolution is discussed. Symmetric solutions frequently appear even under asymmetric conditions in the environment. An attempt is made to compare the results of the theoretical analysis with experimental data of the rabbit intestinal Na + /glucose-symporter.
Type of Medium:
Online Resource
ISSN:
0218-3390
,
1793-6470
DOI:
10.1142/S0218339095000150
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
1995
detail.hit.zdb_id:
2026740-X
SSG:
12
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