In:
Journal of Clinical Laboratory Analysis, Wiley, Vol. 28, No. 6 ( 2014-11), p. 461-464
Abstract:
Kawasaki disease (KD) is an acute, self‐limited vasculitis in infants and young children. Interleukin‐10 (IL‐10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL‐10 serum levels have been reported in the KD patients. Methods In this study, we investigated whether IL‐10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. Results Higher G allele frequencies of IL‐10 at ‐1082 position were observed in KD patients with CAA compared to the controls ( P = 0.016, OR: 2.86, 95% CI, 1.17–6.98). In addition, higher IL‐10 GCC haplotype frequencies were also observed in KD patients with CAA ( P = 0.016, OR: 2.85, 95% CI, 1.17–6.98). Conclusion Our data support the possibility that IL‐10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.
Type of Medium:
Online Resource
ISSN:
0887-8013
,
1098-2825
DOI:
10.1002/jcla.2014.28.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2001635-9
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