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  • Hindawi Limited  (15)
  • English  (15)
  • 2010-2014  (15)
Material
Publisher
  • Hindawi Limited  (15)
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Language
  • English  (15)
Years
  • 2010-2014  (15)
Year
  • 1
    Online Resource
    Online Resource
    Tract-Based Bayesian Multivariate Analysis of Mild Traumatic Brain Injury
    Hindawi Limited ; 2014
    In:  Computational and Mathematical Methods in Medicine Vol. 2014 ( 2014), p. 1-4
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2014 ( 2014), p. 1-4
    Abstract: Purpose . Detecting brain regions characterizing mild traumatic brain injury (mTBI) by combining Tract-Based Spatial Statistics (TBSS) and Graphical-model-based Multivariate Analysis (GAMMA). Materials and Methods . This study included 39 mTBI patients and 28 normal controls. Local research ethics committee approved this prospective study. Diffusion-tensor imaging was performed in mTBI patients within 7 days of injury. Skeletonized fractional anisotropy (FA) maps were generated by using TBSS. Brain regions characterizing mTBI were detected by GAMMA. Results . Two clusters of lower frontal white matter FA were present in mTBI patients. We constructed classifiers based on FA values in these two clusters to differentiate mTBI and controls. The mean accuracy, sensitivity, and specificity, across five different classifiers, were 0.80, 0.94, and 0.61, respectively. Conclusions . Combining TBSS and GAMMA can detect neuroimaging biomarkers characterizing mTBI.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2014/120182
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2256917-0
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  • 2
    Online Resource
    Online Resource
    A 3-Arm, Randomized, Controlled Trial of Heat-Sensitive Moxibustion Therapy to Determine Superior Effect among Patients with Lumbar Disc Herniation
    Hindawi Limited ; 2014
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2014 ( 2014), p. 1-7
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Abstract: Systematic reviews of moxibustion for LDH have identified ponderable evidence, especially for heat-sensitive moxibustion (HSM). Therefore, we designed and carried out the large sample trial to evaluate it. 456 patients were recruited from 4 centers in China and were randomly divided into three groups by the ratio of 1 : 1 : 1 to HSM (152) group, conventional moxibustion (152) group, and conventional drug plus acupuncture (152) group. Compared with usual care, there was a statistically significant reduction in mean M-JOA score at 2 weeks and 6 months for HSM (3.8 ± 2.6 versus 8.5 ± 2.9; 3.7 ± 2.2 versus 10.1 ± 2.9) and conventional moxibustion (7.9 ± 3.0 versus 8.5 ± 2.9; 8.9 ± 3.1 versus 10.1 ± 2.9). Compared with conventional moxibustion group, HSM group showed greater improvement in all the outcomes. The mean dose of moxibustion was 41.13 ± 5.26 (range 21–60) minutes in the HSM group. We found that HSM was more effective in treating patients with LDH, compared with conventional moxibustion and conventional drug plus acupuncture. This finding indicated that the application of moxibustion on the heat-sensitive points is a good moxibustion technique in treating disease.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2014/154941
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2148302-4
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  • 3
    Online Resource
    Online Resource
    3′ Splice Site Sequences of Spinal Muscular Atrophy Related SMN2 Pre-mRNA Include Enhancers for Nearby Exons
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-9
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-9
    Abstract: Spinal muscular atrophy (SMA) is a human genetic disease which occurs because of the deletion or mutation of SMN1 gene. SMN1 gene encodes the SMN protein which plays a key role in spliceosome assembly. Although human patients contain SMN2, a duplicate of SMN1, splicing of SMN2 produces predominantly exon 7 skipped isoform. In order to understand the functions of splice site sequences on exon 7 and 8, we analyzed the effects of conserved splice site sequences on exon 7 skipping of SMN2 and SMN1 pre-mRNA. We show here that conserved 5′ splice site sequence of exon 7 promoted splicing of nearby exons and subsequently reduced splicing of distant exons. However, to our surprise, conserved 3′ splice site sequence of exon 7 and 8 did not promote splicing of nearby exons. By contrast, the mutation inhibited splicing of nearby exons and subsequently promoted splicing of distant exons. Our study shows that 3′ splice sites of exon 7 and 8 contain enhancer for their splice site selection, in addition to providing cleavage sites.
    Type of Medium: Online Resource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/617842
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2075968-X
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  • 4
    Online Resource
    Online Resource
    The Review of GRACE Data Applications in Terrestrial Hydrology Monitoring
    Hindawi Limited ; 2014
    In:  Advances in Meteorology Vol. 2014 ( 2014), p. 1-9
    Details
    In: Advances in Meteorology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-9
    Abstract: The Gravity Recovery and Climate Experiment (GRACE) satellite provides a new method for terrestrial hydrology research, which can be used for improving the monitoring result of the spatial and temporal changes of water cycle at large scale quickly. The paper presents a review of recent applications of GRACE data in terrestrial hydrology monitoring. Firstly, the scientific GRACE dataset is briefly introduced. Recently main applications of GRACE data in terrestrial hydrological monitoring at large scale, including terrestrial water storage change evaluation, hydrological components of groundwater and evapotranspiration (ET) retrieving, droughts analysis, and glacier response of global change, are described. Both advantages and limitations of GRACE data applications are then discussed. Recommendations for further research of the terrestrial water monitoring based on GRACE data are also proposed.
    Type of Medium: Online Resource
    ISSN: 1687-9309 , 1687-9317
    URL: Article
    DOI: 10.1155/2014/725131
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2486777-9
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  • 5
    Online Resource
    Online Resource
    An Integrated Model for Simulating Regional Water Resources Based on Total Evapotranspiration Control Approach
    Hindawi Limited ; 2014
    In:  Advances in Meteorology Vol. 2014 ( 2014), p. 1-10
    Details
    In: Advances in Meteorology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-10
    Abstract: Total evapotranspiration and water consumption (ET) control is considered an efficient method for water management. In this study, we developed a water allocation and simulation (WAS) model, which can simulate the water cycle and output different ET values for natural and artificial water use, such as crop evapotranspiration, grass evapotranspiration, forest evapotranspiration, living water consumption, and industry water consumption. In the calibration and validation periods, a “piece-by-piece” approach was used to evaluate the model from runoff to ET data, including the remote sensing ET data and regional measured ET data, which differ from the data from the traditional hydrology method. We applied the model to Tianjin City, China. The Nash-Sutcliffe efficiency (Ens) of the runoff simulation was 0.82, and its regression coefficient R 2 was 0.92. The Nash-Sutcliffe Efficiency (Ens) of regional total ET simulation was 0.93, and its regression coefficient R 2 was 0.98. These results demonstrate that ET of irrigation lands is the dominant part, which accounts for 53% of the total ET. The latter is also a priority in ET control for water management.
    Type of Medium: Online Resource
    ISSN: 1687-9309 , 1687-9317
    URL: Article
    DOI: 10.1155/2014/345671
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2486777-9
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  • 6
    Online Resource
    Online Resource
    Preparation and Characterization of Magnetic Mesoporous Bioactive Glass/Carbon Composite Scaffolds
    Hindawi Limited ; 2013
    In:  Journal of Chemistry Vol. 2013 ( 2013), p. 1-11
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2013 ( 2013), p. 1-11
    Abstract: The magnetic Fe-MBG/C composite scaffolds with enhanced mechanical strength and multifunctionality have been successfully prepared. The study showed that the Fe-MBG/C composite scaffolds with the porosity of ca. 80% had interconnected macropores (200–500 µm) and mesopores (3.7–4.4 nm) and significantly enhanced the compressive strength compared to the pure MBG scaffolds. Importantly, the Fe-MBG/C composite scaffolds exhibited good bioactivity and sustained drug release property. At the same time, the Fe-MBG/C composite scaffolds could generate heat to raise the temperature of surrounding environment in an alternating magnetic field due to their superparamagnetic behavior. Therefore, the magnetic Fe-MBG/C composite scaffolds could form a multifunctional platform with bone regeneration, magnetic hyperthermia, and local drug delivery and have more potential for use in the regeneration of the critical-sized bone defects caused by bone tumors.
    Type of Medium: Online Resource
    ISSN: 2090-9063 , 2090-9071
    URL: Article
    DOI: 10.1155/2013/893479
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
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  • 7
    Online Resource
    Online Resource
    Comparative Effectiveness of the Deqi Sensation and Non-Deqi by Moxibustion Stimulation: A Multicenter Prospective Cohort Study in the Treatment of Knee Osteoarthritis
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-7
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-7
    Abstract: Substantial evidence has supported that moxibustion stimulates a unique phenomenon of Deqi, heat-sensitive moxibustion sensation. This study consisted of a multicenter, prospective cohort study with two parallel arms (A: heat-sensitive moxibustion sensation group; B: nonheat-sensitive moxibustion sensation group). All forms of moxibustion were applied unilaterally on the right leg with a triangle shape of three acupuncture points simultaneously (bilateral Xi Yan (EX-LE5) and He Ding (EX-LE2)). After one month the primary outcome parameter GPCRND-KOA showed significant differences between groups: trial group 5.23 ± 2.65 (adjusted mean ± SE) 95% CI [4.44 ~ 6.01] versus control group 7.43 ± 2.80 [6.59 ~ 8.26], P = 0.0001 . Significant differences were manifested in total M-JOA score during the follow-up period ( P = 0.0006 ). Mean knee circumference indicated significant difference between the groups ( P = 0.03 ; P = 0.007 ). Overall, this evidence suggested that the effectiveness of the Deqi sensation group might be more superior than the non-Deqi sensation one in the treatment of KOA. This study was aimed at providing scientific evidence on the Deqi sensation of moxibustion and at showing that heat-sensitive moxibustion sensation is essential to achieve the preferable treatment effects of KOA.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/906947
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 8
    Online Resource
    Online Resource
    First-Principles Study of the Structural Stability and Electronic and Elastic Properties of Helium in α -Zirconium
    Hindawi Limited ; 2014
    In:  Advances in Condensed Matter Physics Vol. 2014 ( 2014), p. 1-8
    Details
    In: Advances in Condensed Matter Physics, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
    Abstract: First-principles calculations within density functional theory have been performed to investigate the behaviors of helium in α -zirconium. The most favorable interstitial site for He in α -Zr is not an ordinary tetrahedral or octahedral site, but a basal octahedral site with a formation energy as low as 2.40 eV. The formation energy reduces to 1.25 eV in the presence of preexisting vacancies. The analysis on the density of states and the charge density has been carried out. In addition, the influences of He and small He-V complexes on the elastic properties have been studied. The He-V complexes have been found to greatly affect the elastic properties compared with He alone.
    Type of Medium: Online Resource
    ISSN: 1687-8108 , 1687-8124
    URL: Article
    DOI: 10.1155/2014/929750
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2501251-4
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  • 9
    Online Resource
    Online Resource
    Influence of the Molecular Adhesion Force on the Indentation Depth of a Particle into the Wafer Surface in the CMP Process
    Hindawi Limited ; 2014
    In:  Advances in Materials Science and Engineering Vol. 2014 ( 2014), p. 1-6
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Abstract: By theoretical calculation, the external force on the particle conveyed by pad asperities and the molecular adhesion force between particle and wafer are compared and analyzed quantitatively. It is confirmed that the molecular adhesion force between particle and wafer has a great influence on the chemical mechanical polishing (CMP) material removal process. Considering the molecular adhesion force between particle and wafer, a more precise model for the indentation of a particle into the wafer surface is developed in this paper, and the new model is compared with the former model which neglected the molecular adhesion force. Through theoretical analyses, an approach and corresponding critical values are applied to estimate whether the molecular adhesion force in CMP can be neglected. These methods can improve the precision of the material removal model of CMP.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2014/696893
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2501025-6
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  • 10
    Online Resource
    Online Resource
    Reactive Oxygen Species in Vascular Formation and Development
    Hindawi Limited ; 2013
    In:  Oxidative Medicine and Cellular Longevity Vol. 2013 ( 2013), p. 1-14
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2013 ( 2013), p. 1-14
    Abstract: Reactive oxygen species (ROS) are derived from the metabolism of oxygen and are traditionally viewed as toxic byproducts that cause damage to biomolecules. It is now becoming widely acknowledged that ROS are key modulators in a variety of biological processes and pathological states. ROS mediate key signaling transduction pathways by reversible oxidation of certain signaling components and are involved in the signaling of growth factors, G-protein-coupled receptors, Notch, and Wnt and its downstream cascades including MAPK, JAK-STAT, NF- κ B, and PI3K/AKT. Vascular formation and development is one of the most important events during embryogenesis and is vital for postnasal tissue repair. In this paper, we will discuss how ROS regulate different steps in vascular development, including smooth muscle cell differentiation, angiogenesis, endothelial progenitor cells recruitment, and vascular cell migration.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2013/374963
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2455981-7
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