In:
Angewandte Chemie, Wiley, Vol. 130, No. 11 ( 2018-03-05), p. 2909-2913
Abstract:
Described here is the first example of a rhodium‐catalyzed carboacylation/aromatization cascade of a C=O bond by C−C activation. In this transformation, a reactive rhodaindanone complex is regioselectively generated and adds across a C=O bond with subsequent elimination, thus providing a unique strategy to access a multisubstituted benzofuran scaffold. A diverse range of benzofuran analogues were obtained in good yields. Mechanistic studies show a tricyclic lactone was a viable intermediate. Application of this methodology to the total synthesis of C13‐deOH‐viniferifuran and C13‐deOH‐diptoindonesin G was achieved.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.11
DOI:
10.1002/ange.201713179
Language:
English
Publisher:
Wiley
Publication Date:
2018
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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