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  • English  (2)
  • 2005-2009  (2)
  • 2008  (2)
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  • English  (2)
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  • 2005-2009  (2)
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  • 2008  (2)
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  • 1
    In: European Journal of Neurology, Wiley, Vol. 15, No. 5 ( 2008-05), p. 512-519
    Abstract: Background and purpose:  Previous studies have shown significantly higher mortality and vascular morbidity amongst patients with ischaemic stroke onset at a young age compared with controls after a mean observation time of more than 11 years. Methods:  In the present cross‐sectional study, we measured the carotid intima‐media thickness (IMT) in 140 (75%) of 187 survivors of ischaemic stroke after a mean observation time of 11.9 years. Their mean age when included was 41.1 years. IMT was measured by B‐mode ultrasonography. Results:  Total maximum IMT  〈 1.0 mm was found in 34 (24%) patients, [1.0–1.2 mm) in 29 (21%) patients, [1.2–1.5 mm) in 29 (21%) patients and ≥1.5 mm in 48 (34%) patients. Increasing total maximum IMT was related to increasing age, male gender, recurrent ischaemic stroke, coronary atherosclerosis, peripheral atherosclerosis, smoking, hypertension and diabetes mellitus. Discussion:  IMT changes confirm increased vascular morbidity in patients who suffered ischaemic stroke at a young age.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2020241-6
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2008
    In:  Scandinavian Journal of Immunology Vol. 67, No. 4 ( 2008-04), p. 400-403
    In: Scandinavian Journal of Immunology, Wiley, Vol. 67, No. 4 ( 2008-04), p. 400-403
    Abstract: Proteasome antibodies were detected by enzyme‐linked immunosorbent assay in two of the 45 (4.4%) patients with lung cancer, 0 of the 39 patients with breast cancer and six of the 51 (11.8%) patients with ovarian cancer. Six of the 47 (12.8%) patients with relapsing remitting multiple sclerosis had proteasome antibodies, as well as two of the 100 (2%) blood donors. Significant higher odds ratios compared to the blood donors were found for the patients with ovarian cancer (OR: 6.4; 95% CI: 1.1–68) and multiple sclerosis (OR: 7.1; 95% CI: 1.2–74). There was no association between proteasome antibodies and metastases or onconeural antibodies. The antibodies showed reactivity to 23, 25 and 27 kD proteins of the 20S proteasome using Western blot. The increased prevalence of proteasome antibodies in patients with ovarian cancer or multiple sclerosis may reflect cellular damage and release of intracellular antigens. Whether the antibodies take part in the clearance of released proteasomes and thus participate in the pathogenesis of cancer or autoimmune disease is not known.
    Type of Medium: Online Resource
    ISSN: 0300-9475 , 1365-3083
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2020954-X
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