In:
SynOpen, Georg Thieme Verlag KG, Vol. 04, No. 02 ( 2020-04), p. 38-43
Abstract:
A convenient route to conjugates of 2-thiohydantoins and menadione with linkers of various chemical nature through a two-stage reaction sequence (direct amination of the menadione with a functional amine followed by modification of a functional group) is presented. Optimal conditions for the direct amination of menadione using alkyl amines with substituents such as azide, alkyne, hydroxyl, amine, halogen, and carboxyl have been developed. Further modification of selected functionalities using CuAAC or esterification reactions with 2-thiohydantoines has been performed.
Type of Medium:
Online Resource
ISSN:
2509-9396
DOI:
10.1055/s-0040-1707519
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2020
detail.hit.zdb_id:
2889779-1
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