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  • MDPI AG  (5)
  • Zhang, Peng  (5)
  • English  (5)
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  • MDPI AG  (5)
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  • English  (5)
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  • 1
    Online Resource
    Online Resource
    Structure Inheritance in Nanoparticle Ink Direct-Writing Processes and Crack-Free Nano-Copper Interconnects Printed by a Single-Run Approach
    MDPI AG ; 2019
    In:  Materials Vol. 12, No. 9 ( 2019-05-13), p. 1559-
    Details
    In: Materials, MDPI AG, Vol. 12, No. 9 ( 2019-05-13), p. 1559-
    Abstract: When nanoparticle conductive ink is used for printing interconnects, cracks and pores are common defects that deteriorate the electrical conductivity of the printed circuits. Influences of the ink solvent, the solid fraction of the ink, the pre-printing treatment and the sintering parameters on the interconnect morphology and conductivity were investigated. It was found that the impacts of all these factors coupled with each other throughout the whole procedure, from the pre-printing to the post-printing processes, and led to a structure inheritance effect. An optimum process route was developed for producing crack-free interconnects by a single-run direct-writing approach using home-made nano-copper ink. A weak gel was promoted in the ink before printing in the presence of long-chain polymers and bridging molecules by mechanical agitation. The fully developed gel network prevented the phase separation during ink extrusion and crack formations during drying. With the reducing agents in the ink and slow evaporation of the ink solvent, compact packing and neck joining of copper nanoparticles were obtained after a two-step sintering process. The crack-free interconnects successfully produced have a surface roughness smaller than 1.5 μm and the square resistances as low as 0.01 Ω/□.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma12091559
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2487261-1
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Optimization of Flavonoid Extraction from Salix babylonica L. Buds, and the Antioxidant and Antibacterial Activities of the Extract
    MDPI AG ; 2022
    In:  Molecules Vol. 27, No. 17 ( 2022-09-03), p. 5695-
    Details
    In: Molecules, MDPI AG, Vol. 27, No. 17 ( 2022-09-03), p. 5695-
    Abstract: The present study was designed to evaluate the chemical extraction, chemical composition, and antioxidant and antibacterial properties of the total flavonoids in Willow Buds (TFW). We investigated the optimal extraction of TFW using response surface methodology (RSM). Chemical compounds were analyzed using Q-Orbitrap LC–MS/MS. The DPPH radical scavenging capacity, hydroxy radical inhibitory ability, and superoxide anion radical inhibitory ability were explored to determine the antioxidant properties of flavonoid extractions. The antibacterial effect was assessed via minimal inhibitory concentration. The results demonstrated that the optimal extraction conditions were an ethanol concentration of 50%, a time of 35 min, and a liquid/material ratio of 70:1 mL/g. Under these conditions, the yield of TFW was 7.57%. Eight flavonoids, a phenolic glycoside, and an alkaloid were enriched in the Willow Buds. The TFW exhibited significant antioxidant activity, with IC50 values of 0.18-0.24 mg/mL and antimicrobial activity against Escherichia coli, Salmonella enterica, Staphylococcus aureus, and Streptococcus pneumoniae. TFW may be explored as potential and natural compounds in food and pharmacological applications.
    Type of Medium: Online Resource
    ISSN: 1420-3049
    URL: Article
    DOI: 10.3390/molecules27175695
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2008644-1
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  • 3
    Online Resource
    Online Resource
    Automatic Extraction of Marine Aquaculture Zones from Optical Satellite Images by R3Det with Piecewise Linear Stretching
    MDPI AG ; 2022
    In:  Remote Sensing Vol. 14, No. 18 ( 2022-09-06), p. 4430-
    Details
    In: Remote Sensing, MDPI AG, Vol. 14, No. 18 ( 2022-09-06), p. 4430-
    Abstract: In recent years, the development of China’s marine aquaculture has brought serious challenges to the marine ecological environment. Therefore, it is significant to classify and extract the aquaculture zone and spatial distribution in order to provide a reference for aquaculture management. However, considering the complex marine aquaculture environment, it is difficult for traditional remote sensing technology and deep learning to achieve a breakthrough in the extraction of large-scale aquaculture zones so far. This study proposes a method based on the combination of piecewise linear stretching and R3Det to classify and extract raft aquaculture and cage aquaculture zones. The grayscale value is changed by piecewise linear stretching to reduce the influence of complex aquaculture backgrounds on the extraction accuracy, to effectively highlight the appearance characteristics of the aquaculture zone, and to improve the image contrast. On this basis, the aquaculture zone is classified and extracted by R3Det. Taking the aquaculture zone of Sansha Bay as the research object, the experimental results showed that the accuracy of R3Det in extracting the number of raft aquaculture and cage aquaculture zones was 98.91% and 97.21%, respectively, and the extraction precision of the area of the aquaculture zone reached 92.08%. The proposed method can classify and extract large-scale marine aquaculture zones more simply and efficiently than common remote sensing techniques.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    URL: Article
    DOI: 10.3390/rs14184430
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2513863-7
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  • 4
    Online Resource
    Online Resource
    Remarkable Effects of Urbanization on Forest Landscape Multifunctionality in Urban Peripheries: Evidence from Liaoyuan City in Northeast China
    MDPI AG ; 2021
    In:  Forests Vol. 12, No. 12 ( 2021-12-15), p. 1779-
    Details
    In: Forests, MDPI AG, Vol. 12, No. 12 ( 2021-12-15), p. 1779-
    Abstract: Forest landscape multifunctionality (FLM) provides multiple benefits, such as climate regulation, water storage, and biodiversity maintenance. However, the external factors limiting FLM have not been fully identified, although addressing them could contribute to sustainable development. The present study aimed to identify and quantify the role of urbanization as an external factor that affects FLM. To this end, impervious area changes in Liaoyuan, China, were observed from 2000 to 2018, and 10 buffer zones at 500 m intervals were established outside the city. Within each buffer zone, we analyzed changes in forest landscape functions, including habitat maintenance, carbon sequestration, and water yield, as well as changes in the multifunctionality of their composition. The urbanization of Liaoyuan was significant in 2000–2018. The functions of the forest landscape became stronger and more stable as they were located further away from the urban edge. We refer to this pattern as the gradient effect of urbanization. Specifically, urbanization affected the investigated functions at a distance of 1000–2500 m. The FLM showed a more significant gradient effect of urbanization. The impact distance of urbanization on the FLM increased from 3000 m in 2000 to over 5000 m in 2018. This impact distance increased significantly whenever urbanization strengthened significantly (i.e., in 2005–2010 and 2015–2018). These findings are instructive for forest and urban managers working to achieve multiple Sustainable Development Goals.
    Type of Medium: Online Resource
    ISSN: 1999-4907
    URL: Article
    DOI: 10.3390/f12121779
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2527081-3
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  • 5
    Online Resource
    Online Resource
    An Anti-Cancer Peptide LVTX-8 Inhibits the Proliferation and Migration of Lung Tumor Cells by Regulating Causal Genes’ Expression in p53-Related Pathways
    MDPI AG ; 2020
    In:  Toxins Vol. 12, No. 6 ( 2020-06-02), p. 367-
    Details
    In: Toxins, MDPI AG, Vol. 12, No. 6 ( 2020-06-02), p. 367-
    Abstract: Spider venom has been found to show its anticancer activity in a variety of human malignancies, including lung cancer. In this study, we investigated the anti-cancer peptide toxin LVTX-8, with linear amphipathic alpha-helical conformation, designed and synthesized from the cDNA library of spider Lycosa vittata. Multiple cellular methods, such as CCK-8 assay, flow cytometry, colony formation assay, Transwell invasion and migration assay, were performed to detect peptide-induced cell growth inhibition and anti-metastasis in lung cancer cells. Our results demonstrated that LVTX-8 displayed strong cytotoxicity and anti-metastasis towards lung cancer in vitro. Furthermore, LVTX-8 could suppress the growth and metastasis of lung cancer cells (A549 and H460) in nude mouse models. Transcriptomics, integrated with multiple bioinformatics analysis, suggested that the molecular basis of the LVTX-8-mediated inhibition of cancer cell growth and metastasis manifested in two aspects: Firstly, it could restrain the activity of cancer cell division and migration through the functional pathways, including “p53 hypoxia pathway” and “integrin signaling”. Secondly, it could regulate the expression level of apoptotic-related proteins, which may account for programmed apoptosis of cancer cells. Taken together, as an anticancer peptide with high efficiency and acceptable specificity, LVTX-8 may become a potential precursor of a therapeutic agent for lung cancer in the future.
    Type of Medium: Online Resource
    ISSN: 2072-6651
    URL: Article
    DOI: 10.3390/toxins12060367
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2518395-3
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