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  • American Association for Cancer Research (AACR)  (26)
  • Yang, Gong  (26)
  • English  (26)
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  • 1
    Online Resource
    Online Resource
    Abstract 6491: Temporal changes in circulating sex hormones and aromatase activity and associations with lung cancer survival in postmenopausal women
    American Association for Cancer Research (AACR) ; 2023
    In:  Cancer Research Vol. 83, No. 7_Supplement ( 2023-04-04), p. 6491-6491
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 83, No. 7_Supplement ( 2023-04-04), p. 6491-6491
    Abstract: Background: Exogenous sex hormone supplements had been associated with increased lung cancer mortality in a large clinical trial. No study to date has evaluated temporal trajectories of circulating sex hormones and aromatase activity and their associations with lung cancer survival. Objective: To characterize temporal changes in prediagnostic levels of circulating sex hormones and aromatase activity and to evaluate their associations with overall survival in lung cancer patients. Methods: Included in the analysis were 385 incident lung cancer patients identified in a large prospective cohort among postmenopausal women who had never used cigarette products nor exogenous sex hormone supplements. Concentrations of sex hormones were quantitated using LC-MS/MS assays in prediagnostic plasma samples. The product-substrate molar ratio of estrone to androstenedione was used as an index of aromatase activity (IAA). A multivariable Cox model with restricted cubic spline functions was used to calculate hazard ratio (HR) for overall survival. Results: Of 385 patients with lung cancer, 308 died during a median follow-up of 18.1 years. Initial analyses in all patients showed that higher levels of circulating estrone and IAA and lower levels of androstenedione and testosterone were associated with poorer overall survival after adjusting for nonclinical covariates. In analyses restricted to those with clinical data (n=281), stronger associations were found after further adjustment for tumor stage and treatment regimens. Compared with patients at the median level of IAA, adjusted HRs (95% CI) for total mortality in those at the 30th, 70th, 90th and 95th percentiles were 0.98 (0.84-1.13), 1.05 (0.94-1.16), 1.28 (1.06-1.54), and 1.64 (1.27-2.12), respectively, with P-overall & lt; 0.001. A similar positive association was observed for estrone. In contrast, inverse associations were seen for androgens. For example, compared with the median level of testosterone, HRs (95% CI) for those at the 5th, 10th, 30th, 70th percentiles were 2.10 (1.43-3.09), 1.69 (1.29-2.23), 1.45 (1.19-1.76), and 0.86 (0.78-0.94), respectively, with P-overall = 0.001. Further, we found that circulating levels of sex hormones changed during disease progression. The closer the hormone measurement to cancer diagnosis the higher the IAA and estrone levels (P-overall & lt; 0.001 for both), and the temporal change plateaued 10 years before cancer diagnosis (P-nonlinearity & lt; 0.001 for both). An opposite temporal pattern was found for testosterone. Moreover, the significant association between sex hormones and lung cancer survival was only observed when sex hormones were measured within 10 years before diagnosis. Conclusions: Findings from our study, for the first time, demonstrate temporal changes in circulating sex hormones and their associations with lung cancer survival in postmenopausal women. Citation Format: Yingya Zhao, Xiao-Ou Shu, Yu-Tang Gao, Mark M. Kushnir, Qiuyin Cai, Hui Cai, Qing Lan, Nathaniel Rothman, Wei Zheng, Gong Yang. Temporal changes in circulating sex hormones and aromatase activity and associations with lung cancer survival in postmenopausal women. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6491.
    Type of Medium: Online Resource
    ISSN: 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2023-6491
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2023
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  • 2
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    Intra-Person Variation of Urinary Biomarkers of Oxidative Stress and Inflammation
    American Association for Cancer Research (AACR) ; 2010
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 19, No. 4 ( 2010-04-01), p. 947-952
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 19, No. 4 ( 2010-04-01), p. 947-952
    Abstract: Background: Oxidative stress and inflammation have been linked to many chronic diseases including cancer and cardiovascular diseases. Urinary levels of F2-isoprostanes (F2-IsoPs), 2,3-dinor-5,6-dihydro-15-F2t-IsoP (15-F2t-IsoP-M), a major metabolite of F2-IsoPs, prostaglandin E2 metabolite (PGE-M), and leukotriene E4 (LTE4) have been proposed as biomarkers for oxidative stress and inflammation. However, little information is available regarding the intra-person variation of these biomarkers, hindering their application in epidemiologic studies. Methods: We evaluated the intra-person variation of these four urinary biomarkers among 48 randomly chosen participants of a validation study of a population-based cohort, the Shanghai Men's Health Study. Four spot urine samples, collected during each season over a 1-year period, were measured for these biomarkers. Results: The intraclass correlation coefficients for F2-IsoPs, 15-F2t-IsoP-M, PGE-M, and LTE4 were 0.69, 0.76, 0.67, and 0.64, respectively. The Spearman correlation coefficients, derived by using bootstrap analysis of single spot measurements and the average of the other three seasonal measurements, were 0.47, 0.60, 0.61, and 0.57 for F2-IsoPs, 15-F2t-IsoP-M, PGE-M, and LTE4. Except for high correlations between F2-IsoPs and 15-F2t-IsoP-M (r = 0.65), the other biomarkers were moderately correlated (r = 0.21-0.44). Conclusions: Our study results suggest that these four urinary biomarkers have relatively low intra-person variation over a 1-year period. Impact: Spot measurements of F2-IsoPs, 15-F2t-IsoP-M, PGE-M, and LTE4 could be useful as biomarkers of oxidative stress and inflammation status for epidemiologic studies. Cancer Epidemiol Biomarkers Prev; 19(4); 947–52. ©2010 AACR.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-10-0046
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
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  • 3
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    Genetic Polymorphisms in the TGF- β 1 Gene and Breast Cancer Survival
    American Association for Cancer Research (AACR) ; 2004
    In:  Cancer Research Vol. 64, No. 3 ( 2004-02-01), p. 836-839
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 64, No. 3 ( 2004-02-01), p. 836-839
    Abstract: The effect of genetic polymorphisms in the TGF-β1 gene at codon 10 (T+29C), codon 25 (G+74C), and the promoter region [C → T at −509 from the transcription site, (C-509T)] on breast cancer survival was evaluated among a cohort of 1111 patients. The median follow-up time for the cohort was 5.17 years after cancer diagnosis. No DNA sequence variation at codon 25 of the TGF-β1 gene was found, whereas polymorphisms in C-509T and T+29C were in strong linkage disequilibrium. Patients who carried the C allele of T+29C polymorphism had a reduced 5-year disease-free survival rate (75.6% for T/C, and 78.2% for C/C) compared with the T/T genotype (85.1%; P, 0.04); the age-adjusted hazard ratio was 1.5 (95% confidence interval, 1.1–2.2). Adjustment for clinical prognostic factors slightly attenuated the association (hazard ratio, 1.4, 95% confidence interval, 1.0–1.9). Our study suggests that genetic polymorphisms in the TGF-β1 gene may play a role in breast cancer progression.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/0008-5472.CAN-03-3492
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2004
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  • 4
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    Abstract 102: Circulating C-reactive protein and colorectal cancer risk: a report from the Shanghai Men's Health Study.
    American Association for Cancer Research (AACR) ; 2013
    In:  Cancer Research Vol. 73, No. 8_Supplement ( 2013-04-15), p. 102-102
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 73, No. 8_Supplement ( 2013-04-15), p. 102-102
    Abstract: Chronic inflammation has been implicated in the pathogenesis of colorectal cancer. C-reactive protein (CRP), a biomarker of systemic inflammation, has been investigated in various populations for its association with colorectal cancer risk, but results have been inconsistent. We examined pre-diagnostic circulating levels of CRP with colorectal cancer risk among 288 colorectal cancer cases and 576 frequency-matched controls nested within the Shanghai Men's Health Study (2002-2006), a population-based cohort study of 61,483 men. Baseline plasma CRP levels were 47% higher among men who subsequently developed colorectal cancer than among those who remained free of the disease (1.12 μg/ml vs. 0.76 μg/ml; P & lt;0.001). Multivariate analyses showed a dose-dependent relationship between CRP and colorectal cancer risk (P-trend=0.001); men in the highest tertile with CRP & gt;1.19 μg/ml had 1.88-fold (95%CI: 1.24-2.86) increased odds of developing colorectal cancer compared with men in the lowest tertile with CRP & lt;0.45 μg/ml. The association was observed for both colon and rectal cancers, became stronger after excluding subjects who took any antibiotics during past 7 days, and was restricted to cancer cases diagnosed within 4 years of blood collection (ORs for the highest tertile being 3.28 (95%CI: 1.28-8.37), 3.68 (95%CI: 1.62-8.38), and 1.05 (95%CI: 056-1.97), respectively for cases diagnosed within 2, 2-4 and 4 years after blood draw). The findings from our study suggest that circulating CRP level is positively associated with colorectal cancer risk in Chinese men, and this association, at least in part, is explained by inflammation related to cancerous or precancerous processes. Citation Format: Jie Wu, Qiuyin Cai, Honglan Li, Hui Cai, Jing Gao, Gong Yang, Wei Zheng, Yong-Bing Xiang, Xiao-ou Shu. Circulating C-reactive protein and colorectal cancer risk: a report from the Shanghai Men's Health Study. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 102. doi:10.1158/1538-7445.AM2013-102
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2013-102
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2013
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  • 5
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    Abstract 5310: A prospective study of dietary polyunsaturated fatty acid intakes and lung cancer risk
    American Association for Cancer Research (AACR) ; 2017
    In:  Cancer Research Vol. 77, No. 13_Supplement ( 2017-07-01), p. 5310-5310
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 13_Supplement ( 2017-07-01), p. 5310-5310
    Abstract: Background. Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti-inflammatory properties. Results from epidemiologic studies, however, have been inconclusive. We prospectively evaluated the association of dietary PUFA intakes and lung cancer risk in two population-based cohort studies, the Shanghai Men’s Health Study (SMHS) and Shanghai Women’s Health Study (SWHS). Methods. A total of 130,823 study participants (i.e., 60,427 men and 70,396 women) were included in the current analysis. Dietary fatty acid intakes were derived from data collected at the baseline by validated food frequency questionnaires. Cox proportional hazards model was applied to assess the association between PUFAs intake and lung cancer risk with adjustment for age, smoking status, smoking packs-year (men only), drinking status, BMI, physical activity status, total energy, red meat intake, vegetable intake, vitamin supplemental use, menopausal status and hormone replacement therapy (women only). Results. We found an inverse association between total PUFA intakes and lung cancer risk [hazard ratios (HRs) and respective 95% confidence intervals (CIs) for quintiles 2, 3, 4, and 5 versus quintile 1 were 0.73 (0.56-0.95), 0.78 (0.59-1.03), 0.64 (0.47-0.87) and 0.55 (0.37-0.82) in SMHS and 0.69 (0.53-0.90), 0.76 (0.58-0.99), 0.60 (0.44-0.81), and 0.53 (0.36-0.79) in SWHS)]. A similar pattern was observed for consumption of linoleic acid, total n-6 PUFAs and the ratio n-6 PUFAs/n-3 PUFAs in adenocarcinoma patients. This inverse association was more likely in male ever-smokers for total PUFAs, linoleic acid and total n-6 PUFAs. On the other hand, EPA intake was positively associated with lung cancer risk in female never-smokers [HRs and 95% CIs: 1.10 (0.85-1.42), 1.36 (1.05-1.77), 1.28 (0.97-1.88) and 1.30 (0.97-1.74), for quintiles 2-5 versus quintile 1] . A similar positive association between DHA intake and lung cancer risk in female never-smokers was also observed. Conclusions. Total polyunsaturated fatty acid, linoleic and total n-6 PUFA intakes were associated with decreased risk of lung cancer. EPA and DHA intakes were associated with an increased risk of lung cancer among female never-smokers. Financial Support: This work was supported by grants from the US National Institutes of Health/National Cancer Institute (R37 CA070867 and UM1 CA182910 - to Wei Zheng; R01 CA082729, UM1 CA173640 and R25 CA160056 - to Xiao-Ou Shu) Citation Format: Hung N. Luu, Harvey J. Murff, Honglan Li, Qiuyin Cai, Yu-Tang Gao, Jing Gao, Hui Cai, Gong Yang, Qing Lan, Yong-Bing Xiang, Wei Zheng, Xiao-Ou Shu. A prospective study of dietary polyunsaturated fatty acid intakes and lung cancer risk [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5310. doi:10.1158/1538-7445.AM2017-5310
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2017-5310
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2017
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  • 6
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    Abstract LB-412: Urinary polyphenols, GST copy number variation, and breast cancer risk: Results from the Shanghai Women's Health Study (SWHS)
    American Association for Cancer Research (AACR) ; 2010
    In:  Cancer Research Vol. 70, No. 8_Supplement ( 2010-04-15), p. LB-412-LB-412
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 70, No. 8_Supplement ( 2010-04-15), p. LB-412-LB-412
    Abstract: Background: In vitro studies found that the flavanol epigallocatechin (EGC) and flavonols, but not the flavanol epicatechin (EC), activated glutathione s-transferases (GST), a family of phase II enzymes which detoxify reactive oxygen species, such as catechol estrogen metabolites. Objective: To investigate whether urinary excretion of tea polyphenols interacted with GST polymorphism in relation to breast cancer risk. Design: We conducted a study of 353 incident breast cancer cases and 701 individually-matched controls nested within the Shanghai Women's Health Study cohort of women aged 40-70 years at baseline. Liquid chromatography tandem mass spectrometry was used to measure urinary excretion of flavanols and flavonols. Real-time multiplex PCR were used to quantify the copy number variation for the GSTM1 and GSTT1 genes. Results: Urinary excretion of flavonols and flavanols, particularly, EGC(p=0.02), were significantly higher among those null for GSTM1 than those positive for GSTM1. Furthermore, urinary excretion of flavanol EGC significantly interacted with GSTM1 polymorphism (p=0.04), while flavonols, particularly kaempferol, may interact with both GSTM1 and GSTT1 genotype in relation to breast cancer. As a result, flavanols (primarily EGC) and flavonols significantly interacted with the joint genotypes of GSTM1 and GSTT1 in relation to breast cancer risk. Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, whereas flavonols, particularly kaempferol, were significantly associated with an increased risk of breast cancer for those possessing both GSTM1 and GSTT1. Conclusion: These results, if confirmed, may provide a new avenue for the personalized prevention of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-412.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM10-LB-412
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
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  • 7
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    Abstract 119: Urinary biomarkers of oxidative stress and breast cancer survival among Chinese breast cancer survivors.
    American Association for Cancer Research (AACR) ; 2013
    In:  Cancer Research Vol. 73, No. 8_Supplement ( 2013-04-15), p. 119-119
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 73, No. 8_Supplement ( 2013-04-15), p. 119-119
    Abstract: Background: Systemic oxidative stress has been implicated in the pathogenesis and progression of many chronic diseases, including breast cancer. To our knowledge, no study has investigated the association of biomarkers of systemic oxidative stress after cancer treatment and breast cancer prognosis. Methods: We conducted a pilot study to investigate the association of systemic oxidative stress after primary cancer treatment with mortality in a nested case-control study in the Shanghai Breast Cancer Survival Study (SBCSS). Urinary levels of 15-F(2t)-isoprostane (15-F(2t)-IsoP) and one of its major metabolites (2,3-dinor-5,6-dihydro-15-F(2t)-IsoP (15-F(2t)-IsoP-M)), two well-studied biomarkers of systemic oxidative stress, were measured using gas chromatography/negative ion chemical ionization mass spectrometry for 57 deceased breast cancer patients (cases; 88% due to breast cancer) and 103 matched surviving breast cancer patients (controls) in the SBCSS with available post-cancer treatment urinary samples. Cases and controls were aged 26-70 years and were matched approximately 1:2 on age at diagnosis (+/- 1 year), stage (I-III), and year of diagnosis (2003-2004). Biomarkers were adjusted for creatinine concentrations and expressed as ng/mg of creatinine. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were derived from conditional logistic regression models, conditioned on age, stage, and year of diagnosis. Results: Elevated 15-F(2t)-IsoP levels, categorized based on the median level (≥1.73; & lt;1.73(reference)), were inversely associated with mortality (adjusted OR = 0.36, 95% CI: 0.14-0.96) after adjustment for known clinical prognostic factors (including cancer treatment and tumor characteristics), body mass index, vitamin supplement use, and weeks between breast cancer diagnosis and urine collection. The inverse association was marginally significant when 15-F(2t)-IsoP was categorized based on tertiles (p for trend = 0.08). In contrast, elevated 15-F(2t)-IsoPM levels, categorized based on the median level (≥0.91; & lt;0.91 (reference)), were associated with a statistically non-significant increased risk of mortality (adjusted OR = 1.39, 95% CI: 0.62-3.09). Conclusion: These preliminary results suggest differing associations for 15-F(2t)-IsoP and 15-F(2t)-IsoPM with mortality among breast cancer survivors. To our knowledge, this is the first study to investigate the association between 15-F(2t)-IsoP or 15-F(2t)-IsoP-M levels and breast cancer survival. Results from this pilot study require conformation in future larger studies. Citation Format: Sarah J. Nechuta, Qiuyin Cai, Ying Zheng, Ginger L. Milne, Hui Cai, Qi Dai, Gong Yang, Wei Zheng, Wei Lu, Xiao Ou Shu. Urinary biomarkers of oxidative stress and breast cancer survival among Chinese breast cancer survivors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 119. doi:10.1158/1538-7445.AM2013-119
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2013-119
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2013
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  • 8
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    Abstract 627: Physical activity and inflammatory and oxidative status markers in Chinese women
    American Association for Cancer Research (AACR) ; 2012
    In:  Cancer Research Vol. 72, No. 8_Supplement ( 2012-04-15), p. 627-627
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 627-627
    Abstract: Background: Leisure-time physical activity has been linked to lower circulating levels of inflammatory markers. Few studies have examined the association of non-recreational and household physical activity with inflammatory and oxidative stress markers. This study comprehensively evaluated the association of inflammatory and oxidative stress markers with physical activity, overall and by domains of physical activity, with a particular focus on both routine non-recreational and household physical activity, in a subset of 1,005 participants of the Shanghai Women's Health Study. Methods: Plasma cytokines (interleukin-6 [IL-6], IL-1α, tumor necrosis factor-β [TNFα] ) and C-reactive protein and urinary F2-isoprostanes and their metabolites were measured in 1,005 healthy Chinese women aged 40-70 years. Usual physical activity was assessed through in-person interview using a validated physical activity questionnaire. Results: Recreational and non-recreational physical activity contributed 6.2% and 93.8%, respectively, of energy expenditure from overall physical activity in this study population of middle-aged and elderly women. Two major sub-types of non-recreational physical activity, routine physical activity (walking and biking for transportation) and household physical activity, accounted for 49.6% and 38.2% of energy expenditure of overall physical activity. After adjusting for age, body mass index, lifestyle and dietary factors, diseases of the musculoskeletal system and connective tissue, Charlson comorbidity index, and history of chronic infectious and inflammation-related diseases using a general linear regression model, concentrations of IL-6, IL-1α, and TNFα decreased with increasing quartiles of overall physical activity, with a difference between extreme quartiles of 28.5% (P for trend = 0.002), 26.9% (0.005), and 18.4% (0.001), respectively. The inverse trends were similar when the analysis was restricted to non-recreational physical activity (P for trend = 0.004 for IL-6, 0.03 for IL-1α, and 0.009 for TNFα), or its components walking and biking for transportation (P for trend = 0.02, 0.048, and 0.005, respectively) and household activity (P for trend = 0.07, 0.08, and 0.03, respectively). Recreational physical activity was inversely associated with TNFα level (P for trend = 0.01). No significant associations were observed between physical activity and oxidative stress markers. Interpretation: This study suggests that overall physical activity (both recreational and non-recreational) may reduce the circulating levels of inflammatory markers. Our finding of a potential role of low-level physical activity, such as routine non-recreational and household activity, in reducing inflammation may have important public health implications because these types of activities are the main contributor to total physical activity in elderly women. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 627. doi:1538-7445.AM2012-627
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM2012-627
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2012
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  • 9
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    Abstract B88: Plasma carotenoids, tocopherols, retinol and breast cancer risk: Results from the Shanghai Women's Health Study
    American Association for Cancer Research (AACR) ; 2008
    In:  Cancer Prevention Research Vol. 1, No. 7_Supplement ( 2008-11-01), p. B88-B88
    Details
    In: Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 1, No. 7_Supplement ( 2008-11-01), p. B88-B88
    Abstract: B88 Objective Studies conducted in Western countries have suggested that lipophilic antioxidants, particularly carotenoids, may have preventive effects on the risk of breast cancer. We prospectively investigated the associations of serum levels of tocopherols, total retinol, total and specific types of carotenoids with the risk of developing breast cancer among Chinese women; a population with low risk of breast cancer and low prevalence of vitamin supplement use. Methods A nested case-control study was conducted within the cohort of the Shanghai Women’s Health Study including 365 newly-diagnosed cases and 726 individually-matched controls 40-70 years of age who provided a blood sample at baseline. Multivariate conditional logistic regression analyses were used to assess associations between breast cancer risk and antioxidants. Results Overall, we did not observe significant associations between any of the tocopherols, retinol and most carotenoids, and breast cancer risk. Plasma levels of lycopene other than trans, 5-cis and 7-cis were associated with a reduced risk with an OR of 0.56 (95% CI: 0.32-0.97) for the highest quartile versus the lowest after adjusting for plasma levels of other antioxidants. This inverse association was seen predominantly among premenopausal women with a corresponding OR (95% CI) of 0.36 (0.16-0.80). We also found that trans α-cryptoxanthin was associated with a reduced risk of breast cancer in a dose-response manner, with a corresponding OR of 0.59 (95% CI: 0.34-1.01) (P trend, 0.02) and the inverse association for trans α-cryptoxanthin appeared in both pre- and post-menopausal women. Conclusions Our study did not show strong evidence for an overall protective effect of plasma lipophilic antioxidants on breast cancer risk. The few significant inverse associations for subtype carotenoids need to be confirmed in future studies. Citation Information: Cancer Prev Res 2008;1(7 Suppl):B88.
    Type of Medium: Online Resource
    ISSN: 1940-6207 , 1940-6215
    URL: Article
    DOI: 10.1158/1940-6207.PREV-08-B88
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2008
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  • 10
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    Abstract A92: Oxidative stress, obesity, and breast cancer risk: results from the Shanghai women health study (SWHS) .
    American Association for Cancer Research (AACR) ; 2008
    In:  Cancer Prevention Research Vol. 1, No. 7_Supplement ( 2008-11-01), p. A92-A92
    Details
    In: Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 1, No. 7_Supplement ( 2008-11-01), p. A92-A92
    Abstract: A92 Background Increased reactive oxygen species may exhaust the antioxidant capability of human defense systems, leading to oxidative stress and cancer development. Urinary F2-isoprostanes, secondary end products of lipid peroxidation, are more accurate markers of oxidative stress than other available biomarkers. No prospective study has investigated whether levels of 15-F2t-Isop and its metabolite (15-F2t-IsopM) are related to breast cancer risk. Methods We conducted a nested case-control study within the Shanghai Women’s Health Study, a population-based cohort study of 74,942 Chinese women between 40 and 70 years of age. Prediagnostic urinary 15-F2t-Isop and 15-F2t-IsopM were measured by gas chromatography-mass spectrometry for 436 breast cancer cases and 852 individually matched controls. Results Urinary excretion of isoprostanes was not significantly different between cases and controls. However, among overweight women, levels of isoprostanes were positively associated with breast cancer risk, which became stronger with increasing BMI. Among women with a BMI≥29, the odds ratio (OR) increased to10.27 (2.41-43.80) for the highest compared to the lowest tertile of 15-F2t-IsopM (p for trend, 0.003; p for interaction, 0.0004). In contrast, 15-F2t-Isop and 15-F2t-IsopM were inversely associated with breast cancer risk among non-overweight women. Among women with a BMI≤23, breast cancer risk was reduced with increasing 15-F2t-Isop levels in a dose-response manner (p for trend, 0.006), with an OR of 0.46 (95%CI: 0.26-0.80) for the highest tertile versus the lowest (p for interaction, 0.006). Conclusion Our results suggest that the role of oxidative stress in breast cancer development may depend on adiposity and menopausal status. Citation Information: Cancer Prev Res 2008;1(7 Suppl):A92.
    Type of Medium: Online Resource
    ISSN: 1940-6207 , 1940-6215
    URL: Article
    DOI: 10.1158/1940-6207.PREV-08-A92
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2008
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