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  • 1
    Online Resource
    Online Resource
    Informa UK Limited ; 2010
    In:  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
    In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Informa UK Limited
    Type of Medium: Online Resource
    ISSN: 1178-7007
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2494854-8
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  • 2
    Online Resource
    Online Resource
    Hogrefe Publishing Group ; 2000
    In:  Therapeutische Umschau Vol. 57, No. 8 ( 2000-08-01), p. 498-503
    In: Therapeutische Umschau, Hogrefe Publishing Group, Vol. 57, No. 8 ( 2000-08-01), p. 498-503
    Abstract: The cornerstone of the evaluation of an obese patient is the medical examination in combination with a few selected obesity specific measurements. Key elements in the obesity specific history are the patient’s weight history, the diet history, evaluation of the present and past physical activity pattern and the evaluation of the patient’s target weight. Central elements in the examination are the computation of the body mass index (BMI) as well the measurement of the waist circumference. The waist circumference shows a higher degree of correlation with different morbidities than the BMI. A waist circumference of 〉 80 cm in women and 〉 94 cm in men is associated with an increased overall morbidity risk. In general a minimal biochemical work-up – including fasting glucose, total cholesterol, HDL and triacylglycerol, urate, electrolytes and TSH – is enough. Special tests (screening examination for e.g. M. Cushing) are only indicated in the case of clinical suspicon; the determination of leptin is presently of no diagnostic nor therapeutic relevance. The indication for weight reduction should be formulated individually. In the long term weight stability has to be regarded as a success for most patients. Presently the prevention of weight gain and obesity is still the safest and most efficient “therapeutic” approach.
    Type of Medium: Online Resource
    ISSN: 0040-5930 , 1664-2864
    Language: English
    Publisher: Hogrefe Publishing Group
    Publication Date: 2000
    detail.hit.zdb_id: 82044-1
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  • 3
    Online Resource
    Online Resource
    Hogrefe Publishing Group ; 2002
    In:  Vasa Vol. 31, No. 2 ( 2002-05-01), p. 75-80
    In: Vasa, Hogrefe Publishing Group, Vol. 31, No. 2 ( 2002-05-01), p. 75-80
    Abstract: Hintergrund: Oxidative Modifikation von Low-Density-Lipoproteinen (LDL) verursacht eine vermehrte Einlagerung von Lipiden in die Arterienwand und steigert somit das atherogene Potential. Patienten haben verschiedene Lipoprotein-Profile, die von der Verteilung der LDL-Subgruppen beeinflusst werden. Die kleine dichte LDL 3 -Fraktion ist durch eine schnelle Oxidationsbereitschaft geprägt. Um festzustellen, ob eine Verbindung zwischen Hypertonie, LDL-Oxidation und -Subgruppenverteilung besteht, haben wir bei 14 normotensiven Probanden ohne familiäre hypertonische Belastung (NT), bei 13 Normotensiven mit familiärer Belastung (NT-FH) und bei 10 Hypertensiven ohne (HT) und 11 mit familiärer Belastung (HT-FH) die LDL-Oxidationsbereitschaft und -Subfraktionen bestimmt. Patienten und Methoden: LDL wurde mit Kupfer (1.6 mumol/L) oxidiert und der Verlauf der Oxidation in vitro mit der kontinuierlichen spektrophotometrischen Absorption gemessen. Die quantitaive Verteilung der 3 LDL-Subgruppen wurde mit der Kapillarelektrophorese bestimmt. Ergebnisse: NT-FH und hypertensive Patienten haben kürzere antioxidative Phasen als die Kontrollpersonen (NT: 116 ± 36 Minuten; NT-FH 92 ± 32 Minuten, p 〈 0.05; HT: 95 ± 41 Minuten; HT-FH: 76 ± 33 Minuten, p 〈 0.05). Im Vergleich zu NT konnte bei hypertensiven Patienten mit familiärer Belastung ein signifikantes Überwiegen der LDL 3 -Subgruppe festgestellt werden (23.5 ± 4.6% versus NT: 19.3 ± 6.6%). Zusätzlich zeigte die statistische Analyse einen ähnlichen Trend für die anderen Patientengruppen (NT-FH: 20.4 ± 7.4%, HT: 21.4 ± 4.6%). Schlussfolgerung: Die Zunahme der LDL 3 -Subgruppe ist vermutlich mit einer gesteigerten LDL-Oxidationsbereitschaft und einem erhöhten Risiko für vaskuläre Erkrankungen bei genetischer Prädisposition und manifester Hypertonie verbunden.
    Type of Medium: Online Resource
    ISSN: 0301-1526 , 1664-2872
    Language: English
    Publisher: Hogrefe Publishing Group
    Publication Date: 2002
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  • 4
    In: British Journal of Haematology, Wiley, Vol. 108, No. 1 ( 2000-01), p. 176-181
    Type of Medium: Online Resource
    ISSN: 0007-1048
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2000
    detail.hit.zdb_id: 1475751-5
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 2015
    In:  Journal of Science and Medicine in Sport Vol. 19 ( 2015-12), p. e12-
    In: Journal of Science and Medicine in Sport, Elsevier BV, Vol. 19 ( 2015-12), p. e12-
    Type of Medium: Online Resource
    ISSN: 1440-2440
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 2230157-4
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  • 6
    Online Resource
    Online Resource
    Hogrefe Publishing Group ; 2002
    In:  Swiss Surgery Vol. 8, No. 2 ( 2002-04-01), p. 67-73
    In: Swiss Surgery, Hogrefe Publishing Group, Vol. 8, No. 2 ( 2002-04-01), p. 67-73
    Abstract: Objective: The three-dimensional relation of a liver tumour to the intrahepatic vascular trees is basis of operation planning in liver surgery. Yet it has not been proven whether 3D reconstruction and further computerised processing will enhance precision of operation planning in liver surgery which has been based on the liver segment classification of Couinaud up to now. Design: Our interdisciplinary group (department of Surgery, German Cancer Research Center and Department of Radiology) has developed a new interactive computer-based quantitative 3D operation planning system for liver surgery which is being introduced into the clinical routine. The system quantifies the organ structures semiautomatically, defines resection planes depending on safety margins and the vascular trees, and presents the data in digital movies as well as in quantitative reports. We conducted a clinical trial to evaluate whether 3D reconstruction will lead to an improved operation planning. Data of 7 virtual patients were presented to a total of 81 surgeons in different levels of training. The tumours had to be assigned to a liver segment and subsequently drawn together with the operation proposals into a liver model. The precision of both was measured quantitatively for each surgeon and stratified concerning 2D and different types of 3D presentations. Results: The 3D anatomy can be visualised in high quality which results in good perception of the third dimension (depth). Tumour assignment to liver segments was significantly correlated to the level of training (p 〈 0.05). There was a significant increase (p 〈 0.001) in the precision of tumour localisation by 51% and resection proposal from 2D through 3D reconstructions by 13%-21%. Quantitative differences of the simplified Couinaud's classification of the liver segments compared to the true vascular anatomy of up to 40% were found. Conclusion: The impact of individual 3D-reconstruction on surgical planning has been proven to be significant and increases precision quantitatively. The merit of Couinaud's classification may be enhanced by individualisation of the segment borders in future.
    Type of Medium: Online Resource
    ISSN: 1023-9332
    Language: English
    Publisher: Hogrefe Publishing Group
    Publication Date: 2002
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