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  • Rodriguez-Luna, David  (3)
  • English  (3)
  • 2015-2019  (3)
  • 1
    Online Resource
    Online Resource
    When to Stop : Detrimental Effect of Device Passes in Acute Ischemic Stroke Secondary to Large Vessel Occlusion
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Stroke Vol. 50, No. 7 ( 2019-07), p. 1781-1788
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 50, No. 7 ( 2019-07), p. 1781-1788
    Abstract: Substantial proportion of patients who achieve successful recanalization of acute ischemic stroke due to large vessel occlusion do not achieve good functional outcome. We aim to analyze the effect of number of thrombectomy device passes and degree of the recanalization (by modified Thrombolysis in Cerebral Infarction) on the clinical and functional outcome. Methods— Five hundred forty-two consecutive patients underwent mechanical thrombectomy for large vessel occlusion in the anterior circulation at a single tertiary stroke center. Baseline characteristics, number of passes, recanalization degree, clinical outcome at 24 hours (measured by National Institutes of Health Scale score), and functional outcome (measured by modified Rankin Scale at 90 days) were registered. Multivariate analysis was performed to determine the association of number of passes and degree of recanalization with dramatical clinical recovery (final National Institutes of Health Scale score ≤2 or decrease in 8 or more National Institutes of Health Scale score points in 24 hours) and good functional outcome (modified Rankin Scale score ≤2 at 90 days). Results— Four hundred fifty-nine patients (84%) achieved successful recanalization (modified Thrombolysis in Cerebral Infarction 2B–3), 213 (39%) of them after first device pass. In the multivariate analysis, first-pass recanalization and modified Thrombolysis in Cerebral Infarction 3 were independent predictors of good functional outcome (odds ratio, 2.5; 95% CI, 1.4–4.5; P =0.002 and odds ratio, 2.6 CI; 1.5–4.7; P =0.001, respectively) and dramatical clinical recovery (odds ratio, 1.8; 95% CI, 1.1–3; P =0.032 and odds ratio, 2.9; 95% CI, 1.7–5.1; P 〈 0.001, respectively). Rate of recanalization declined after each pass 39% (213/542), 35% (113/310), 33% (63/190), and 24% (26/154) for passes 1 to 4, respectively and 28% (45/158) for every attempt above 4 passes ( P 〈 0.001). In patients who achieved recanalization, a linear association between number of passes and good functional outcome was observed: 1 pass (58.6%), 2 passes (50.5%), 3 passes (48.4%), 4 passes (38.5%), or 5 or more passes (25.6%; P 〈 0.001) as compared with patients who did not achieve recanalization (16.9%). Conclusions— High number of device passes and less degree of recanalization are associated with worse outcome in patients with acute ischemic stroke secondary to large vessel occlusion. Future studies should investigate the optimal number of passes that should be attempted in patients without substantial recanalization.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.119.025088
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 80381-9
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Abstract WP129: The Yield of Antiplatelet Resistance in Carotid and Vertebral Artery Stenting
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. Suppl_1 ( 2018-01-22)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. Suppl_1 ( 2018-01-22)
    Abstract: Background: Platelet function measured by Aggregometry tests (AT) are commonly used to measure the response to antiplatelets in patients undergoing intracranial and coronary stenting. However, its relevance in carotid and vertebral stents (CVS) is unsettled. We aimed to determine the yield of antiplatelet resistance (AR) in CVS patients, and its relationship with early restenosis and new ischemic lesions on magnetic resonance imaging (MRI). Methods: We studied consecutive patients undergoing CVS. Platelet function was assessed before stenting by means of VerifyNow-assay using Aspirin and P2Y12 cartridges. Antiplatelet reactivity was defined using the cut-off values ARU≥550 as Aspirin resistance (AASR) and PRU≥220 as Clopidogrel resistance (CR). Patients received baseline and 5-day MRI. Periprocedural complications, the new ischemic lesions at 5-day MRI and stent permeability by carotid ultrasound at 24 hours, 5 days and 3 months were analysed. Results: A total of 366 patients were screened. Of those, 246 patients were enrolled and tested for platelet function. A total of 135 patients (54.2%) showed AR, 48 AASR (19.5%) and 112 CR (45.5%). Aspirin dose after the test was increased in 21 patients (45.7%). In 22 patients (20%) with CR the daily dose was increased, in 40 patients (37.7%) an extra-loading dose was administrated and in 9 patients (8.4%) we increased both. At 24 hours, one patient showed restenosis 〉 50% and another an occlusion (0.4 and 0.4% respectively). At 5 days, 8 patients had restenosis 〈 50% (13.1%) and in 43 (17.5%) MRI showed new ischemic lesions. At 3 months 9 patients had stenosis 〉 50% (4.5%) and stenting-related recurrence was observed in 3 (1.4%). A larger size lesions at 5-day MRI (OR 0.143; 95%CI 0.028-0.719) and a multi-territorial ischemic pattern (OR 0.143; 95%CI 0.075-0.893) were associated with lack of response to Clopidogrel therapy. No significant differences in AASR were observed across different groups. Conclusion: The yield of antiplatelet resistance in our series was 54.2%. Clopidogrel resistance was associated with a larger size and a multi-territorial stroke pattern at 5-day MRI. More studies are needed to elucidate the clinical impact of Aggregometry test and management recommendations.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.49.suppl_1.WP129
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 80381-9
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Abstract WMP40: A Comparison of Three Different Endovascular Approaches for Extracranial Internal Carotid Artery Lesions in the Setting of Tandem Occlusions
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. Suppl_1 ( 2018-01-22)
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. Suppl_1 ( 2018-01-22)
    Abstract: Background: Endovascular treatment (EVT) of extracranial internal carotid artery (ICA) lesions in the setting of tandem occlusions is a challenge, being angioplasty alone (AA) or angioplasty+stenting (AS) the two current approaches. Hemorrhagic transformation (HT) is a major problem when a conventional [self-expanding (SX)] stent is placed, regarding the need of early double antiplatelet therapy. Interestingly, balloon-expanding (BX) stents, due to their less thrombogenicity, may constitute an alternative, so they do not need early antiplatelets. We aimed to study differences in ICA restenosis, HT, clinical outcome and stroke recurrence between patients treated with AA or AS. Methods: Prospective study of consecutive patients with non-cardioembolic ischemic stroke and tandem occlusions, who underwent 〈 6hours EVT from April 2013 to April 2017. We compared rate of ICA high-degree stenosis/occlusion at 24h, HT, clinical outcome (change in NIHSS at 24h and at discharge over NIHSS at admission, and mRS≥2 at 3 months) and stroke recurrence within 3 months between AA and AS (SX and BX stents) groups. Results: Ninety-two patients fulfilled inclusion criteria: mean age 64.6±12.6 years. Forty (43.5%) received AA and 52 (56.5%) AS (61.5% SX stents, 38.5% BX stents). Both groups were comparable in baseline characteristics. Fifty (54.3%) received IV rtPA. Patients who underwent AA presented ICA high-degree stenosis/occlusion at 24h more frequently than those who underwent AS (86.5% vs. 21.2%, p 〈 0.001). No differences were found in HT, clinical outcome and stroke recurrence ( p 〉 0.05 for all comparisons). In the AS group, all SX stents received antiplatelets after EVT, whereas in 75% of cases in the BX group no antiplatelets were started within 24h. However, no differences were found in ICA high-degree stenosis /occlusion at 24h, clinical outcome and stroke recurrence ( p 〉 0.05). We neither found differences in HT. Nevertheless, all cases were asymptomatic in the BX stents group. Conclusions: Emergent ICA stenting seems to have a lower risk of restenosis compared to AA, without a significant increase of HT and stroke recurrence or a worse clinical outcome. BX stents, without early antiplatelet therapy, are a promising alternative to conventional carotid stents.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/str.49.suppl_1.WMP40
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 80381-9
    detail.hit.zdb_id: 1467823-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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