In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 77 ( 2022-11-25)
Abstract:
Despite the robust protection elicited by the COVID-19 mRNA vaccines against SARS-CoV-2 variants of concern, breakthrough infection with Omicron subvariants is common. Determining how breakthrough infection with various omicron subvariants might protect against future variants of concern is crucial information for vaccine development. Here, Muik et al. tested the neutralization potential of serum antibodies from SARS-CoV-2 mRNA–vaccinated people (three doses) who were SARS-CoV-2 naïve or experienced breakthrough infection with BA.1 or BA.2. They found that BA.2 breakthrough infection elicited superior neutralizing antibodies against BA.4/BA.5 virus. This neutralization against BA.4/BA.5 from BA.2 breakthrough infections was equally elicited by antibodies recognizing both the N-terminal domain (NTD) of spike and immunodominant receptor binding domain. Thus, NTD recognizing antibodies generated from BA.2 breakthrough infection may protect people against BA.4/BA.5 infection.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.ade2283
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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