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  • S. Karger AG  (14)
  • Lee, Jae-Hong  (14)
  • English  (14)
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  • S. Karger AG  (14)
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  • English  (14)
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  • 1
    Online Resource
    Online Resource
    Group- and Home-Based Cognitive Intervention for Patients with Mild Cognitive Impairment: A Randomized Controlled Trial
    S. Karger AG ; 2016
    In:  Psychotherapy and Psychosomatics Vol. 85, No. 4 ( 2016), p. 198-207
    Details
    In: Psychotherapy and Psychosomatics, S. Karger AG, Vol. 85, No. 4 ( 2016), p. 198-207
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 We examined the efficacy of group-based cognitive intervention (GCI) and home-based cognitive intervention (HCI) in amnestic mild cognitive impairment (aMCI) and intervention effects on serum brain-derived neurotrophic factor (BDNF). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In this randomized and rater-blinded trial, 293 patients with aMCI from 18 nationwide hospitals were randomized: 96 to the GCI group, 98 to the HCI group and 99 to the control group. For 12 weeks, subjects receiving GCI participated twice per week in group sessions led by trained instructors, and those receiving HCI completed homework materials 5 days per week. They were assessed at baseline, postintervention (PI) and at the 6-month follow-up after the intervention. The primary endpoint was the change from baseline to PI in the modified Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In comparison to the controls (a 0.8-point decrease), the subjects receiving GCI (a 2.3-point decrease, p = 0.01) or HCI (a 2.5-point decrease, p = 0.02) showed significant improvements in the modified ADAS-Cog at PI, respectively. By the 6-month follow-up, those receiving GCI or HCI had better scores in the modified ADAS-Cog than the controls. The changes in BDNF levels significantly correlated with the changes in the modified ADAS-Cog in the GCI (r 〈 i 〉 = 〈 /i 〉 -0.29, p = 0.02 at PI) and HCI (r 〈 i 〉 = 〈 /i 〉 -0.27, p = 0.03 at 6-month follow-up) groups, respectively. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The GCI and HCI resulted in cognitive improvements in aMCI. An enhanced brain plasticity may be a component of the mechanism underpinning the cognitive improvements associated with the cognitive interventions.
    Type of Medium: Online Resource
    ISSN: 0033-3190 , 1423-0348
    URL: Article
    DOI: 10.1159/000442261
    RVK:
    CU 5500
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1472321-9
    SSG: 5,2
    SSG: 15,3
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Effects of Body Weight on the Safety of High-Dose Donepezil in Alzheimer’s Disease: Post hoc Analysis of a Multicenter, Randomized, Open-Label, Parallel Design, Three-Arm Clinical Trial
    S. Karger AG ; 2021
    In:  Dementia and Geriatric Cognitive Disorders Vol. 50, No. 3 ( 2021), p. 289-295
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 50, No. 3 ( 2021), p. 289-295
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Donepezil 23 mg is considered for Alzheimer’s disease (AD) to optimize cognitive benefits; however, increased adverse events (AEs) can negatively influence drug adherence. We investigated whether body weight (BW) differs based on the presence of AEs, and which baseline factors were relevant to the safety of high-dose donepezil. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This study was a post hoc analysis of a multicenter randomized trial between 2014 and 2016. We included patients with moderate to severe AD treated with 10 mg/day of donepezil, and the daily dose was escalated to 23 mg with/without dose titration. Dose titration indicates 15 mg/day of donepezil before escalation or 10 mg and 23 mg/day on alternate days before escalation during the first 4 weeks. The patients were divided into 2 groups based on occurrence of AEs of special interest (AESIs) to compare baseline characteristics. We also assessed relationships between BW and AESIs. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Among the 160 participants in the safety population, the baseline BWs differed between the AESI (+) ( 〈 i 〉 n 〈 /i 〉 = 67) and AESI (−) ( 〈 i 〉 n 〈 /i 〉 = 93) groups. Baseline BW was inversely correlated with the occurrence of AESIs ( 〈 i 〉 p 〈 /i 〉 = 0.020), and this relationship was prominent in the no-dose titration group ( 〈 i 〉 p 〈 /i 〉 = 0.009) but absent in the dose-titration groups ( 〈 i 〉 p 〈 /i 〉 & #x3e; 0.05). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 BW is the most important factor that correlated with cholinergic AEs. Hence, stepwise dose titration should be considered, particularly in patients with low BW, to minimize the inverse relationship between BW and the occurrence of AEs (“Clinicaltrials.gov” No. NCT02550665 registered on September 15, 2015).
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000518470
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 1482186-2
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Co-Occurrence of Seizure and Chorea in a Patient with Nonketotic Hyperglycemia
    S. Karger AG ; 2005
    In:  European Neurology Vol. 54, No. 4 ( 2005), p. 230-232
    Details
    In: European Neurology, S. Karger AG, Vol. 54, No. 4 ( 2005), p. 230-232
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000090717
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482237-4
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    Online Resource
  • 4
    Online Resource
    Online Resource
    False Memory and Alzheimer’s Disease Pathology in Patients with Amnestic Mild Cognitive Impairment: A Study with Amyloid PET
    S. Karger AG ; 2021
    In:  Dementia and Geriatric Cognitive Disorders Extra Vol. 11, No. 2 ( 2021-6-11), p. 172-180
    Details
    In: Dementia and Geriatric Cognitive Disorders Extra, S. Karger AG, Vol. 11, No. 2 ( 2021-6-11), p. 172-180
    Abstract: 〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 False memory, observed as intrusion errors or false positives (FPs), is prevalent in patients with Alzheimer’s disease, but has yet to be thoroughly investigated in patients with amnestic mild cognitive impairment (a-MCI) with Alzheimer’s disease pathology (ADP). We analyzed false versus veridical memory in individuals with a-MCI and measured the utility of false memory for ADP discrimination. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Patients with a-MCI who received neuropsychological testing and amyloid PET were included. Patients were categorized into “with” and “without ADP” groups according to PET results. Memory tests assessed veridical and false memory, and the verity of patient responses was analyzed. A logistic regression model was used to evaluate false memory efficiency in discriminating ADP, and the sensitivity and specificity at the optimal level were estimated using the receiver-operating characteristic curve. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Thirty-seven ADP and 46 non-ADP patients were enrolled. The ADP group made more FPs in the recognition tests, and their response verity was significantly lower in every delayed memory test. No group difference, however, was observed in the veridical memory. The logistic regression analysis demonstrated that as the FPs increased, the risk of ADP increased 1.31 and 1.36 times in the verbal and visual recognition tests, respectively. The discriminatory accuracy of the FPs was estimated “low” to “moderate” in the visual and verbal recognition, respectively, with an optimal cutoff above 2.5. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Increased false memory was the only feature to discriminate ADP from non-ADP in individuals with a-MCI. Further studies regarding false memory and its mechanism are warranted.
    Type of Medium: Online Resource
    ISSN: 1664-5464
    URL: Article
    DOI: 10.1159/000516230
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2021
    detail.hit.zdb_id: 2621464-7
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  • 5
    Online Resource
    Online Resource
    Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS)
    S. Karger AG ; 2015
    In:  Dementia and Geriatric Cognitive Disorders Vol. 40, No. 3-4 ( 2015), p. 158-165
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 40, No. 3-4 ( 2015), p. 158-165
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 The aims of this study were to determine baseline factors related to the progression of subjective memory impairment (SMI) in elderly subjects and to develop a new modeling scale to predict progression. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Elderly subjects with SMI were recruited from the nationwide Clinical Research Centers for Dementia of South Korea (CREDOS) multicenter cohort and divided into two groups: (1) progressed to mild cognitive impairment or Alzheimer's disease or (2) stable without progression. Baseline clinical characteristics were compared between the groups, and the most relevant predictors of progression were assessed. A new modeling scale combining the predictors was developed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In total, 129 subjects with SMI were analyzed. The follow-up duration was 0.5-4.7 years, and the median time to event was 3.64 years. The progressing group (n = 29) differed from the stable group (n = 100) in terms of baseline age, apolipoprotein E4 (APOE4) status, and some cognitive domains. Older age, a lower Mini-Mental State Examination recall score, APOE4 carrier, and a lower verbal delayed recall score were the most relevant predictors of progression, and a new modeling scale with these 4 predictors provided a better explanation of progression. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 SMI subjects with a higher risk of progression can be identified using a new modeling scale and might need further evaluations and more frequent follow-up.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000430807
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1482186-2
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    Online Resource
  • 6
    Online Resource
    Online Resource
    White Matter Changes May Precede Gray Matter Loss in Elderly with Subjective Memory Impairment
    S. Karger AG ; 2016
    In:  Dementia and Geriatric Cognitive Disorders Vol. 42, No. 3-4 ( 2016), p. 227-235
    Details
    In: Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 42, No. 3-4 ( 2016), p. 227-235
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 A limited number of studies addressed MRI-based neurodegenerative changes in subjective memory impairment (SMI). We investigated changes in white matter (WM) microstructures as well as gray matter (GM) macrostructures in subjects with SMI of high and low risk for progression. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A modeling scale (score range, 0-6) developed for prediction of SMI progression was used to divide SMI subjects (n = 46) into two groups: a high risk of progression (score ≥3; n = 19) and a low risk of progression (score ≤2; n = 27). Cross-sectional comparisons were performed using a region-of-interest-based diffusion tensor imaging (DTI) analysis, cortical thickness analysis, and hippocampal volumetry. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The high-risk group had more microstructural disruption shown by lower fractional anisotropy in the hippocampus, parahippocampal gyrus, supramarginal gyrus, and parts of frontotemporal lobes. On the other hand, GM macrostructural changes did not differ between the groups and were not associated with modeling scale scores. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 SMI subjects with a high risk of progression had more WM microstructural disruption than those with a low risk, and the changes were not explained by GM atrophy. Our findings suggest that the degree of microstructural alterations in SMI may be distinctive according to the risk factors and may precede GM atrophy.
    Type of Medium: Online Resource
    ISSN: 1420-8008 , 1421-9824
    URL: Article
    DOI: 10.1159/000450749
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1482186-2
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  • 7
    Online Resource
    Online Resource
    Short- and Long-Term Outcomes of Spontaneous CSF Hypovolemia
    S. Karger AG ; 2005
    In:  European Neurology Vol. 54, No. 2 ( 2005), p. 63-67
    Details
    In: European Neurology, S. Karger AG, Vol. 54, No. 2 ( 2005), p. 63-67
    Abstract: We undertook a study to investigate the short- and long-term outcomes of spontaneous CSF hypovolemia. Fifty-three consecutive patients with spontaneous CSF hypovolemia were included. Short-term outcome was assessed 4 weeks after the treatment in all patients. Long-term outcome after a mean follow-up of 61 months (range, 13–101 months) was evaluated in 26 patients. There were 18 men and 35 women (66%) with an age range of 22–64 years (mean 37 ± 9.5). In assessing the short-term outcome of CSF hypovolemia, we found that complete headache relief was significantly higher in 43 patients who received epidural blood patch (EBP) than in 10 patients treated with supportive measures (p 〈 0.05). After a mean follow-up of 61 months, 25 (96%) of the 26 patients evaluated for long-term outcome had complete headache relief. These results suggest that EBP is safe and effective, resulting in excellent short- and long-term outcomes of CSF hypovolemia.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000087714
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1482237-4
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  • 8
    Online Resource
    Online Resource
    Foix-Chavany-Marie Syndrome after Unilateral Stroke
    S. Karger AG ; 2015
    In:  European Neurology Vol. 74, No. 1-2 ( 2015), p. 84-85
    Details
    In: European Neurology, S. Karger AG, Vol. 74, No. 1-2 ( 2015), p. 84-85
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000437419
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2015
    detail.hit.zdb_id: 1482237-4
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  • 9
    Online Resource
    Online Resource
    Dissociative Language Representation in a Patient with Schizencephaly
    S. Karger AG ; 2020
    In:  European Neurology Vol. 83, No. 5 ( 2020), p. 534-535
    Details
    In: European Neurology, S. Karger AG, Vol. 83, No. 5 ( 2020), p. 534-535
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000510850
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 1482237-4
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  • 10
    Online Resource
    Online Resource
    Clinical and Neuropsychological Characteristics of a Nationwide Hospital-Based Registry of Frontotemporal Dementia Patients in Korea: A CREDOS-FTD Study
    S. Karger AG ; 2014
    In:  Dementia and Geriatric Cognitive Disorders Extra Vol. 4, No. 2 ( 2014-7-10), p. 242-251
    Details
    In: Dementia and Geriatric Cognitive Disorders Extra, S. Karger AG, Vol. 4, No. 2 ( 2014-7-10), p. 242-251
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 We investigated the demographic, clinical, and neuropsychological characteristics of frontotemporal dementia (FTD) from the Clinical Research Center for Dementia of South Korea (CREDOS)-FTD registry. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 200 consecutive patients with FTD recruited from 16 neurological clinics in Korea were evaluated by cognitive and functional assessments, a screening test for aphasia, behavioral questionnaires, motor assessments, and brain MRI or PET. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In our registry, 78 patients were classified as having been diagnosed with behavioral-variant FTD (bvFTD), 70 with semantic dementia (SD), 33 with progressive nonfluent aphasia (PNFA), and 8 with motor neuron disease plus syndrome (MND-plus). The patients with language variants of dementia were older than those with bvFTD. There were no differences in sex ratio, duration of illness, or level of education among the four subgroups. Overall, the patients with bvFTD showed a significantly better performance in cognitive tests. A higher frequency of motor symptoms and a lower frequency of behavioral symptoms were found in PNFA than in bvFTD and SD. The Global Language Index was significantly lower in SD than in bvFTD and PNFA. The MND-plus group had a poorer performance than all the others in all cognitive domains. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The neuropsychological, behavioral, motor, and language characteristics of the four subtypes are comparable with those from other series. However, the proportion of SD (37.0%), which was similar to that of bvFTD (41.3%), was higher in our registry than in other series.
    Type of Medium: Online Resource
    ISSN: 1664-5464
    URL: Article
    DOI: 10.1159/000360278
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2621464-7
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