In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2022-4-25), p. e0009793-
Abstract:
Amebiasis, caused by Entamoeba histolytica , is spreading in developing countries and in many developed countries as a sexually transmitted infection. Here, we evaluated the efficacy of serological screening to identify asymptomatic E . histolytica infection as a potential epidemiological control measure to limit its spread. Methodology/Principal findings This cross-sectional study was carried out between January and March 2021 in an HIV-negative men who have sex with men (MSM) cohort at the National Center for Global Health and Medicine. Serological screening was performed using a commercially available ELISA kit. For seropositive individuals, we performed stool polymerase chain reaction (PCR) to determine current E . histolytica infection. We performed E . histolytica serological screening of 312 participants. None had a history of E . histolytica infection prior to the study. The overall E . histolytica seropositivity was 6.7% (21/312), which was similar to that found by the rapid plasma reagin test (17/312). We identified current infection in 8 of 20 seropositive participants (40.0%) by stool PCR. Conclusions/Significance Our serological screening approach constitutes a potentially practical epidemiological strategy. Active epidemiological surveys, in combination with an effective screening strategy for asymptomatically infected individuals, should be applied to help reduce sexually transmitted E . histolytica infections.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009793
DOI:
10.1371/journal.pntd.0009793.g001
DOI:
10.1371/journal.pntd.0009793.g002
DOI:
10.1371/journal.pntd.0009793.t001
DOI:
10.1371/journal.pntd.0009793.s001
DOI:
10.1371/journal.pntd.0009793.s002
DOI:
10.1371/journal.pntd.0009793.s003
DOI:
10.1371/journal.pntd.0009793.s004
DOI:
10.1371/journal.pntd.0009793.s005
DOI:
10.1371/journal.pntd.0009793.s006
DOI:
10.1371/journal.pntd.0009793.r001
DOI:
10.1371/journal.pntd.0009793.r002
DOI:
10.1371/journal.pntd.0009793.r003
DOI:
10.1371/journal.pntd.0009793.r004
DOI:
10.1371/journal.pntd.0009793.r005
DOI:
10.1371/journal.pntd.0009793.r006
DOI:
10.1371/journal.pntd.0009793.r007
DOI:
10.1371/journal.pntd.0009793.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2429704-5
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