In:
BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
Abstract:
The main cause of death in rheumatoid arthritis (RA) is cardiovascular events. We evaluated the relationship of anticyclic citrullinated peptide (anti-CCP) antibody levels with increased carotid intima-media thickness (cIMT) in RA patients. Methods . Forty-five anti-CCP positive and 37 anti-CCP negative RA patients, and 62 healthy controls (HC) were studied. All groups were assessed for atherogenic index of plasma (AIP) and cIMT. Anti-CCP, C-reactive protein (CRP), and levels of tumor necrosis factor alpha (TNF α ) and interleukin-6 (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA). Results . The anti-CCP positive RA patients showed increased cIMT compared to HC and anti-CCP negative ( P 〈 0.001 ). Anti-CCP positive versus anti-CCP negative RA patients, had increased AIP, TNF α and IL-6 ( P 〈 0.01 ), and lower levels of high density lipoprotein cholesterol (HDL-c) ( P = 0.02 ). The cIMT correlated with levels of anti-CCP ( r = 0.513 , P = 0.001 ), CRP ( r = 0.799 , P 〈 0.001 ), TNF α ( r = 0.642 , P = 0.001 ), and IL-6 ( r = 0.751 , P 〈 0.001 ). In multiple regression analysis, cIMT was associated with CRP ( P 〈 0.001 ) and anti-CCP levels ( P = 0.03 ). Conclusions . Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2698540-8
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