In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 99, No. 1 ( 2002-01-08), p. 84-89
Abstract:
Beetles, like other insects, depend on diuretic and antidiuretic
hormones to control water balance. We have isolated, using head extracts from the beetle Tenebrio molitor , a peptide
that strongly inhibits fluid secretion by the Malpighian tubules of this insect. This antidiuretic factor (ADF) appears to elicit its
effect via cGMP as a second messenger but does not stimulate NO production. It has primary structure:
Val-Val-Asn-Thr-Pro-Gly-His-Ala-Val-Ser-Tyr-His-Val-Tyr-OH. The ADF inhibits tubule secretion with high potency: the EC 50 is
around 10 fM. It bears no significant resemblance to other biologically active neuropeptides. To our knowledge this is the only
endogenous insect ADF acting on Malpighian tubules to be sequenced, and the first coleopteran (beetle) antidiuretic factor fully
characterized to date.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.012436199
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2002
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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