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  • Berger, Michael  (2)
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  • 1
    Online Resource
    Online Resource
    Universal Guide for Skull Extraction and Custom-Fitting of Implants to Continuous and Discontinuous Skulls
    Society for Neuroscience ; 2022
    In:  eneuro Vol. 9, No. 3 ( 2022-05), p. ENEURO.0028-22.2022-
    Details
    In: eneuro, Society for Neuroscience, Vol. 9, No. 3 ( 2022-05), p. ENEURO.0028-22.2022-
    Abstract: Intracranial neurophysiological recordings require chronic implants to provide transcranial access to the brain. Especially in larger animals, which participate in experiments over extended periods of time, implants should match the skull curvature to promote osseointegration and avoid tissue and bacterial ingress over time. Proposed CAD methods for designing implants to date have focused on naive animals with continuous and even skull surfaces and calculate Boolean differences between implant and skull surface to fit the implant to the skull curvature. However, custom-fitting by calculating the difference fails, if a discontinuous skull surface needs to be matched. Also, the difference method does not allow designs with constant material thickness along the skull curvature, e.g., to allow fixed screw lengths. We present a universal step-by-step guide for custom-fitting implants which overcomes these limitations. It is suited for unusual skull conditions, like surface discontinuities or irregularities and includes virtual bending as a process to match skull surfaces while maintaining implant thickness. We demonstrate its applicability for a wide spectrum of scenarios, ranging from complex-shaped single-pieced implants to detailed multicomponent implant systems built on even or discontinuous skull. The guide uses only a few software tools and the final virtual product can be manufactured using CNC milling or 3D printing. A detailed description of this process is available on GitHub including step-by-step video instructions suitable for users without any prior knowledge in CAD programming. We report the experience with these implants over several years in 11 rhesus monkeys.
    Type of Medium: Online Resource
    ISSN: 2373-2822
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1523/ENEURO.0028-22.2022
    DOI: 10.1523/ENEURO.0028-22.2022.ed
    DOI: 10.1523/ENEURO.0028-22.2022.ext1
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2022
    detail.hit.zdb_id: 2800598-3
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  • 2
    Online Resource
    Online Resource
    Home-Enclosure-Based Behavioral and Wireless Neural Recording Setup for Unrestrained Rhesus Macaques
    Society for Neuroscience ; 2023
    In:  eneuro Vol. 10, No. 1 ( 2023-01), p. ENEURO.0285-22.2022-
    Details
    In: eneuro, Society for Neuroscience, Vol. 10, No. 1 ( 2023-01), p. ENEURO.0285-22.2022-
    Abstract: Electrophysiological studies with behaving nonhuman primates often require the separation of animals from their social group as well as partial movement restraint to perform well-controlled experiments. When the research goal per se does not mandate constraining the animals’ movements, there are often still experimental needs imposed by tethered data acquisition. Recent technological advances meanwhile allow wireless neurophysiological recordings at high band-width in limited-size enclosures. Here, we demonstrate wireless neural recordings at single unit resolution from unrestrained rhesus macaques while they performed self-paced, structured visuomotor tasks on our custom-built, stand-alone touchscreen system [eXperimental Behavioral Instrument (XBI)] in their home environment. We were able to successfully characterize neural tuning to task parameters, such as visuo-spatial selectivity during movement planning and execution, as expected from existing findings obtained via setup-based neurophysiology recordings. We conclude that when movement restraint and/or a highly controlled, insulated environment are not necessary for scientific reasons, cage-based wireless neural recordings are a viable option. We propose an approach that allows the animals to engage in a self-paced manner with our XBI device, both for fully automatized training and cognitive testing, as well as neural data acquisition in their familiar environment, maintaining auditory and sometimes visual contact with their conspecifics.
    Type of Medium: Online Resource
    ISSN: 2373-2822
    URL: Article
    DOI: 10.1523/ENEURO.0285-22.2022
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2023
    detail.hit.zdb_id: 2800598-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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