In:
Nature Biotechnology, Springer Science and Business Media LLC, Vol. 40, No. 6 ( 2022-06), p. 855-861
Kurzfassung:
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.
Materialart:
Online-Ressource
ISSN:
1087-0156
,
1546-1696
DOI:
10.1038/s41587-021-01188-9
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2022
ZDB Id:
1494943-X
ZDB Id:
1311932-1
SSG:
12
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