In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 28, No. 11 ( 2013-11), p. 1693-1698
Kurzfassung:
Hyperplastic/serrated polyposis syndrome ( HPS ) is a condition characterized by multiple hyperplastic/serrated colorectal polyps. The risk of colorectal cancer ( CRC ) is increased in HPS . The clinicopathologic characteristics of HPS in J apanese patients are unknown. The aim of this study is to clarify the clinicopathologic features of HPS in J apanese patients. Methods We retrieved records of patients diagnosed with HPS between A pril 2008 and M arch 2011 from the endoscopy database of H iroshima U niversity H ospital. In addition, we mailed a questionnaire to the hospital's 13 affiliated hospitals in J uly 2012. Data collected from the database and questionnaires included patient age, sex, number of hyperplastic/serrated polyps and tubular adenomas, size of the largest polyp, polyp location, resection for polyps, coexistence of HPS with CRC , and the diagnostic criterion met. Results Of the 73 608 patients who underwent colonoscopy, 10 (0.014%) met the criteria for HPS . The mean age of these patients was 58.3 years, and 6 (60%) were men. No subjects had a first‐degree relative with HPS . Four (40%) HPS patients had more than 30 hyperplastic/serrated polyps, and average size of the largest polyp was 19 mm. Three (30%) HPS patients had coexistence of HPS with CRC . In these 3 patients, polyps were observed throughout the colorectum. Conclusions Although HPS was a rare condition in the overall study population, patients with the disease may have high risk of CRC . HPS should be diagnosed correctly and followed up carefully.
Materialart:
Online-Ressource
ISSN:
0815-9319
,
1440-1746
DOI:
10.1111/jgh.2013.28.issue-11
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2013
ZDB Id:
2006782-3
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