In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 78, No. 5 ( 2021-11), p. 1248-1258
Abstract:
There is limited evidence regarding the risks of incident atrial fibrillation (AF) associated with stage 1 isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH), especially among young adults. We aimed to evaluate the association between early stage of hypertension and AF in young adults. From the Korean nationwide health screening database, 2 958 544 subjects aged 20 to 39 years who were not prescribed antihypertensive medication at the index examination in 2009 were included. Subjects were categorized into 8 groups according to the 2017 American College of Cardiology/American Heart Association blood pressure (BP) guidelines: normal BP, elevated BP, stage 1 IDH, stage 1 ISH, stage 1 SDH, stage 2 IDH, stage 2 ISH, and stage 2 SDH. The primary outcome was new-onset AF. During a median follow-up of 8.3 years, 7347 subjects had incident AF (0.3 per 1000 person-years). Compared with normal BP, stage 1 IDH (adjusted hazard ratio, 1.160 [95% CI, 1.086–1.240]) and stage 1 SDH (1.250 [1.165–1.341] ) were associated with higher risks of incident AF, but not stage 1 ISH. Stage 2 IDH, ISH, and SDH were associated with higher risks of incident AF by 24%, 37%, and 61%, respectively. Stage 1 IDH and SDH were associated with higher risks of incident AF compared with normal BP. The risk of incident AF with stage 2 IDH was similar to that of stage 1 SDH. Optimal BP control, including diastolic BP, is associated with the lowest risk of new-onset AF, even among young adults.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/HYPERTENSIONAHA.121.17399
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2094210-2
Permalink