In:
Alimentary Pharmacology & Therapeutics, Wiley, Vol. 48, No. 6 ( 2018-09), p. 664-670
Abstract:
The incidence of hepatocellular carcinoma ( HCC ) in patients with a history of curatively‐treated HCC is higher than in patients with no history of HCC even after sustained virologic response ( SVR ). Aim To investigate differences in the patterns of HCC development after SVR in patients with a history of curatively‐treated HCC and those with no history of HCC , based on gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid‐enhanced magnetic resonance imaging ( EOB ‐ MRI ) findings. Methods EOB ‐ MRI was performed in 164 patients with HCV cirrhosis who achieved SVR by interferon‐free direct‐acting antiviral (DAA) therapy just before the start of therapy. Changes in EOB ‐ MRI findings after SVR were compared prospectively between patients with (n = 62) and without (n = 102) a history of HCC. Results The incidence of HCC after SVR was higher in patients with a history of HCC ( P 〈 0.0001). The prevalence of nonhypervascular hypointense nodules ( NHHN s) by EOB ‐ MRI was significantly higher in patients with a history of HCC at baseline ( P = 0.05). Although there was no difference in the incidence of the hypervascularisation of baseline NHHN s to typical hypervascular HCC between patients with and without a history of HCC , the incidence of direct emergence of hypervascular HCC despite the absence of NHHN s at baseline was significantly higher in patients with a history of HCC ( P 〈 0.0001). Conclusion Direct emergence of hypervascular HCC and a higher prevalence of NHHNs before DD therapy contributed to the higher incidence of HCC after SVR. ( UMIN 000017020).
Type of Medium:
Online Resource
ISSN:
0269-2813
,
1365-2036
DOI:
10.1111/apt.2018.48.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2003094-0
SSG:
15,3
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