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  • SAGE Publications  (48)
  • English  (48)
  • 2015-2019  (48)
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  • SAGE Publications  (48)
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  • English  (48)
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  • 2015-2019  (48)
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  • 1
    Online Resource
    Online Resource
    Expression and significance of molecular profiles on eosinophils of children with food allergy
    SAGE Publications ; 2019
    In:  European Journal of Inflammation Vol. 17 ( 2019-01), p. 205873921986860-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 17 ( 2019-01), p. 205873921986860-
    Abstract: Peripheral blood eosinophils may increase in food allergy (FA). However, the correlation between activation status of blood eosinophils and features of FA are unknown. We collected 25 cases of FA out-patients with increased number of eosinophils and 20 healthy children. Eosinophil surface markers were analyzed by flow cytometry. We found that CD23, CD44, CD54, and CRTH2 were positive on different eosinophils and that their expressions were increased in FA patients compared to the control individuals. There was a positive correlation with strong protein–protein interactions between the four eosinophil surface markers which were functionally involved in regulation of cell killing, interferon-gamma-mediated signaling pathway, and Epstein–Barr virus infection pathway. Thus, blood eosinophils change their phenotype during FA and induce significant gene regulation changes that may cause FA with eosinophilia. Detection of the expression of CD23, CD44, CD54, and CRTH2 on eosinophils can be used as indicators of FA with eosinophilia.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739219868601
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2584683-8
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  • 2
    Online Resource
    Online Resource
    Effect of moxibustion on the expression of GDNF and its receptor GFRα3 in the colon and spinal cord of rats with irritable bowel syndrome
    SAGE Publications ; 2019
    In:  Acupuncture in Medicine Vol. 37, No. 4 ( 2019-08), p. 244-251
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 37, No. 4 ( 2019-08), p. 244-251
    Abstract: Moxibustion treatment has been found to ameliorate clinical symptoms including abdominal pain, diarrhoea and constipation in patients with irritable bowel syndrome (IBS). Herein we investigated the mechanisms underlying the use of moxibustion in a rat model of IBS. Methods: In our study, an IBS model was established in rats by colorectal distension (CRD) stimulus and mustard oil enema. The rats were randomly divided into a normal group, model group, mild moxibustion group, electroacupuncture group, probiotic group and dicetel group. Abdominal withdrawal reflex (AWR) scores were determined within 90 min of the last treatment. The expression of GDNF/GFRα3 protein and mRNA in the colon and spinal cord were detected by immunohistochemistry and quantitative real-time-PCR, respectively. Results: The IBS model rats had significantly higher AWR scores than the normal group ( P 〈 0.01). After mild moxibustion treatment, the AWR score was significantly reduced (20 mm Hg, P 〈 0.05; 40 mm Hg, 60 mm Hg and 80 mm Hg, P 〈 0.01). The model group showed significantly more colonic glial cell line-derived neurotrophic factor (GDNF/GFRα3 (GDNF family receptor α3) protein and mRNA expression in the colon and spinal cord than the normal group ( P 〈 0.01). Compared with the model group, the expression of GDNF/GFRα3 protein and mRNA in the colon and spinal cord of the rats were significantly decreased in the mild moxibustion group (colon: GDNF and GFRα3 protein, P 〈 0.01; GDNF and GFRα3 mRNA, P 〈 0.01; spinal cord: GDNF and GFRα3 protein, P 〈 0.01; GDNF mRNA, P 〈 0.05, GFRα3 mRNA, P 〈 0.01). Conclusions: Our data suggest that moxibustion therapy may mitigate CRD-induced increases in the expression of GDNF and its receptor GFRα3 in the colon and spinal cord in a rat model of IBS.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2017-011455
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2126127-1
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  • 3
    Online Resource
    Online Resource
    High-Pressure Measurements of Temperature and CO 2 Concentration Using Tunable Diode Lasers at 2 μm
    SAGE Publications ; 2016
    In:  Applied Spectroscopy Vol. 70, No. 3 ( 2016-03), p. 474-484
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 70, No. 3 ( 2016-03), p. 474-484
    Abstract: A sensor for simultaneous measurements of temperature and carbon dioxide (CO 2 ) concentration at elevated pressure is developed using tunable diode lasers at 2 µm. Based on some selection rules, a CO 2 line pair at 5006.140 and 5010.725 cm −1 is selected for the TDL sensor. In order to ensure the accuracy and rapidity of the sensor, a quasi-fixed-wavelength WMS is employed. Normalization of the 2 f signal with the 1 f signal magnitude is used to remove the need for calibration and correct for transmission variation due to beam steering, mechanical misalignments, soot, and windows fouling. Temperatures are obtained from comparison of the background-subtracted 1 f-normalized WMS-2 f signals ratio and a 1 f-normalized WMS-2 f peak values ratio model. CO 2 concentration is inferred from the 1 f-normalized WMS-2 f peak values of the CO 2 transition at 5006.140 cm −1 . Measurements of temperature and CO 2 concentration are carried out in static cell experiments ( P = 1–10 atm, T = 500–1200 K) to validate the accuracy and ability of the sensor. The results show that accuracy of the sensor for temperature and CO 2 concentration are 1.66% temperature and 3.1%, respectively. All the measurements show the potential utility of the sensor for combustion diagnose at elevated pressure.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1177/0003702815626672
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    An improved artificial potential field method of trajectory planning and obstacle avoidance for redundant manipulators
    SAGE Publications ; 2018
    In:  International Journal of Advanced Robotic Systems Vol. 15, No. 5 ( 2018-09-01), p. 172988141879956-
    Details
    In: International Journal of Advanced Robotic Systems, SAGE Publications, Vol. 15, No. 5 ( 2018-09-01), p. 172988141879956-
    Abstract: In this article, we present an improved artificial potential field method of trajectory planning and obstacle avoidance for redundant manipulators. Specifically, we not only focused on the position for the manipulator end-effectors but also considered their posture in the course of trajectory planning and obstacle avoidance. We introduced boundaries for Cartesian space components to optimize the attractive field function. Moreover, the manipulator achieved a reasonable speed to move to the target pose, regardless of the difference between the initial pose and target pose. We proved the stability using Lyapunov stability theory by introducing velocity feedforward, when the manipulator moved along a continuous trajectory. Considering the shape of the manipulator joints and obstacles, we set up the collision detection model by projecting the obstacles to link coordinates. In this case, establishing the repulsive field between the nearest points on every joint and obstacles with the closest distance was sufficient for achieving obstacle avoidance for redundant manipulators. The simulation results based on a nine-degree-of-freedom hyper-redundant manipulator, which was designed and made in our laboratory, fully substantiated the efficacy and superiority of the proposed method.
    Type of Medium: Online Resource
    ISSN: 1729-8814 , 1729-8814
    URL: Article
    DOI: 10.1177/1729881418799562
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2202393-8
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  • 5
    Online Resource
    Online Resource
    Eliminating systematic bias from case-crossover designs
    SAGE Publications ; 2019
    In:  Statistical Methods in Medical Research Vol. 28, No. 10-11 ( 2019-11), p. 3100-3111
    Details
    In: Statistical Methods in Medical Research, SAGE Publications, Vol. 28, No. 10-11 ( 2019-11), p. 3100-3111
    Abstract: Case-crossover designs have been widely applied to epidemiological and medical investigations of associations between short-term exposures and risk of acute adverse health events. Much effort has been made in literature on understanding source of confounding and reducing systematic bias by reference-select strategies. In this paper, we explored the nature of bias in the ambi-directional and time-stratified case-crossover designs via simulation using actual air pollution data from urban Edmonton, Alberta, Canada. We further proposed a calibration approach for eliminating systematic bias in estimates (coefficient estimate, 95% confident interval, and p-value). Bias check for coefficient estimation, size check and power check for significance test were done via simulation experiments to show advantages of the calibrated case-crossover studies over the ones without calibration. An application was done to investigate associations between air pollutants and acute myocardial infarction hospitalizations in urban Edmonton. In conclusion, systematic bias in a case-crossover design is often unavoidable, leading to an obvious bias in the estimated effect and an unreliable p value in the significance test. The proposed calibration technique provides an efficient approach to eliminating systematic bias in a case-crossover study.
    Type of Medium: Online Resource
    ISSN: 0962-2802 , 1477-0334
    URL: Article
    DOI: 10.1177/0962280218797145
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2001539-2
    detail.hit.zdb_id: 1136948-6
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  • 6
    Online Resource
    Online Resource
    Dressing scheme and process parameters analysis for bonnet tool in bonnet polishing
    SAGE Publications ; 2017
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 231, No. 19 ( 2017-10), p. 3569-3578
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 231, No. 19 ( 2017-10), p. 3569-3578
    Abstract: Bonnet polishing is widely used in final processing of optical elements, as the bonnet tool has the characteristic of fine surface adaptability and controllable pressure. For the purpose of ensuring the stability and exact controllability of polishing process, it is necessary to make precise dressing of bonnet tool. In this paper, first a dressing scheme using cup diamond wheel is proposed for bonnet tool, and then the feasibility of the dressing scheme is verified by analyzing the trajectory and the envelope of the diamond particles on the cup wheel. After that, the influences of the dressing process parameters on the dressing efficiency and trajectory distribution are defined through theoretical analysis and MATLAB simulation, and by simulation the dressing process parameters are determined. In addition, a trimmed program with variable speed ratio is proposed to homogenize the dressing tracks. Finally, an experiment was conducted to test the simulation result. This paper provides the theoretical basis for actual dressing process of the bonnet tool.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/0954406216647754
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2024890-8
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  • 7
    Online Resource
    Online Resource
    Two Novel Mutations in the C-Terminal Region of Centrosomal Protein 290 ( CEP290 ) Result in Classic Joubert Syndrome
    SAGE Publications ; 2015
    In:  Journal of Child Neurology Vol. 30, No. 6 ( 2015-05), p. 772-776
    Details
    In: Journal of Child Neurology, SAGE Publications, Vol. 30, No. 6 ( 2015-05), p. 772-776
    Abstract: Joubert syndrome is a neurologic disorder with a pathognomonic “molar tooth sign” on brain imaging. The purpose of this study was to identify potential mutations in a Chinese patient with Joubert syndrome by targeted massively parallel sequencing. Taking advantage of high-throughput DNA sequencing technologies, 18 Joubert-causing genes of a Chinese patient with classic Joubert syndrome were sequenced at a time, and 2 novel variants in the CEP290 gene (c.7323_7327delAGAAG and c.6012-2A 〉 G) were identified in this patient. Sanger validation showed that 2 variants were inherited from each parents, respectively. Both variants are located in the C-terminal region of the CEP290 protein and are predicted to be deleterious. The results support that the combination of targeted genes enrichment and next-generation sequencing is valuable molecular diagnostic tool and suitable for clinical application.
    Type of Medium: Online Resource
    ISSN: 0883-0738 , 1708-8283
    URL: Article
    DOI: 10.1177/0883073814535488
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2068710-2
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  • 8
    Online Resource
    Online Resource
    Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization
    SAGE Publications ; 2018
    In:  Technology in Cancer Research & Treatment Vol. 17 ( 2018-01), p. 153303381880998-
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 17 ( 2018-01), p. 153303381880998-
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.1177/1533033818809984
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 9
    Online Resource
    Online Resource
    Comparative Efficacy of Statins for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Chronic Kidney Disease: A Network Meta-Analysis
    SAGE Publications ; 2019
    In:  Angiology Vol. 70, No. 4 ( 2019-04), p. 305-316
    Details
    In: Angiology, SAGE Publications, Vol. 70, No. 4 ( 2019-04), p. 305-316
    Abstract: Contrast-induced acute kidney injury (CI-AKI) is a common complication of iodinated contrast medium administration during cardiac catheterization. Statin treatment has been shown to be associated with reduced risk of CI-AKI; however, the results are inconsistent, especially for patients with chronic kidney disease (CKD). Thus, we conducted a network meta-analysis to evaluate the effects of statins in the prevention of CI-AKI. We systematically searched several databases (including, Embase, PubMed, the Cochrane Library, and ClinicalTrials.gov ) from inception to January 31, 2018. The primary outcome was occurrence of CI-AKI in patients with CKD undergoing cardiac catheterization. Both pairwise and network meta-analysis were performed. Finally, 21 randomized controlled trials with a total of 6385 patients were included. Results showed that statin loading before contrast administration was associated with a significantly reduced risk of CI-AKI in patients with CKD undergoing cardiac catheterization (odds ratio: 0.46; P 〈 .05). Atorvastatin and rosuvastatin administered at high dose may be the most effective treatments to reduce incidence of CI-AKI, with no difference between these 2 agents.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319718801246
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2065911-8
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  • 10
    Online Resource
    Online Resource
    Local Tumor Control and Normal Tissue Toxicity of Pulsed Low-Dose Rate Radiotherapy for Recurrent Lung Cancer : An In Vivo Animal Study
    SAGE Publications ; 2015
    In:  Dose-Response Vol. 13, No. 2 ( 2015-04-01), p. 155932581558850-
    Details
    In: Dose-Response, SAGE Publications, Vol. 13, No. 2 ( 2015-04-01), p. 155932581558850-
    Abstract: This study investigates (1) local tumor control and (2) normal tissue toxicity of pulsed low-dose rate radiotherapy (PLDR) for recurrent lung cancer. Methods: For study 1, nude mice were implanted with A549 tumors and divided into the following 3 groups: (1) control (n = 10), (2) conventional radiotherapy (RT; n = 10), and (3) PLDR (n = 10). Tumor-bearing mice received 2 Gy daily dose for 2 consecutive days. Weekly magnetic resonance imaging was used for tumor growth monitoring. For study 2, 20 mice received 8 Gy total body irradiation either continuously (n = 10) or 40 × 0.2 Gy pulses with 3-minute intervals (n = 10). Results: For study 1, both conventional RT and PLDR significantly inhibited the growth of A549 xenografts compared with the control group ( 〉 35% difference in the mean tumor volume; P 〈 .05). The PLDR results were slightly better than conventional RT (8% difference in the mean tumor volume; P 〉 .05). For study 2, the average weight was 20.94 ± 1.68 g and 25.69 ± 1.27 g and the survival time was 8 days and 12 days for mice treated with conventional RT and PLDR ( P 〈 .05), respectively. Conclusion: This study showed that PLDR could control A549 tumors as effectively as conventional RT, and PLDR induced much less normal tissue toxicity than conventional RT. Thus, PLDR would be a good modality for recurrent lung cancers. Advances in Knowledge: This article reports our results of an in vivo animal investigation of PLDR for the treatment of recurrent cancers, which may not be eligible for treatment because of the dose limitations on nearby healthy organs that have been irradiated in previous treatments. This was the first in vivo study to quantify the tumor control and normal tissue toxicities of PLDR using mice with implanted tumors, and our findings provided evidence to support the clinical trials that employ PLDR treatment techniques.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325815588507
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2440820-7
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