In:
Angewandte Chemie, Wiley, Vol. 126, No. 44 ( 2014-10-27), p. 12016-12021
Abstract:
siRNA delivery remains a major challenge in RNAi‐based therapy. Here, we report for the first time that an amphiphilic dendrimer is able to self‐assemble into adaptive supramolecular assemblies upon interaction with siRNA, and effectively delivers siRNAs to various cell lines, including human primary and stem cells, thereby outperforming the currently available nonviral vectors. In addition, this amphiphilic dendrimer is able to harness the advantageous features of both polymer and lipid vectors and hence promotes effective siRNA delivery. Our study demonstrates for the first time that dendrimer‐based adaptive supramolecular assemblies represent novel and versatile means for functional siRNA delivery, heralding a new age of dendrimer‐based self‐assembled drug delivery in biomedical applications.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v126.44
DOI:
10.1002/ange.201406764
Language:
German
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
506609-8
detail.hit.zdb_id:
1479266-7
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