In:
Angewandte Chemie, Wiley, Vol. 127, No. 49 ( 2015-12), p. 14966-14970
Abstract:
Although the use of reactive oxygen species (ROS) has been extensively studied, current systems employ external stimuli such as light or electrical energy to produce ROS, which limits their practical usage. In this report, biocompatible metals were used to construct a novel electrochemical system that can spontaneously generate H 2 O 2 without any external light or voltage. The corrosion of Mg transfers electrons to Au‐decorated oxidized Ti in an energetically favorable process, and the spontaneous generation of H 2 O 2 in an oxygen reduction reaction was revealed to occur at titanium by combined spectroscopic and electrochemical analyses. The controlled release of H 2 O 2 noticeably enhanced in vitro angiogenesis even in the absence of growth factors. Finally, a new titanium implant prototype was developed by Mg incorporation, and its potential for promoting angiogenesis was demonstrated.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v127.49
DOI:
10.1002/ange.201507352
Language:
German
Publisher:
Wiley
Publication Date:
2015
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505868-5
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514305-6
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505872-7
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1479266-7
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506259-7
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