In:
Transfusionsmedizin, Georg Thieme Verlag KG, Vol. 12, No. 04 ( 2022-11), p. 227-232
Abstract:
Chimerism analysis is important for monitoring engraftment and indicating the
recurrence of malignant cells after allogeneic hematopoietic stem cell transplantation. Highly sensitive methods with a detection limit of recipient
cells (equivalents) below 0,1%, e. g. quantitative PCR, droplet digital PCR and, most recently, Next-Generation Sequencing, can predict a
relapse up to 120 days earlier when compared to less sensitive methods. This review highlights the importance of assessing the dynamics of chimerism in the
low percentage range (below 1%) for the prediction of a relapse. Moreover, the authors propose a classification of different chimerism kinetics
with their reasonable underlying causal effects. The pros and cons of bone marrow samples versus peripheral blood samples and lineage specific chimerism in
the context with high sensitive chimerism analysis methods are discussed.
Type of Medium:
Online Resource
ISSN:
2191-8805
,
2191-8813
Language:
German
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
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