In:
Synlett, Georg Thieme Verlag KG, Vol. 34, No. 08 ( 2023-05), p. 953-957
Abstract:
The first total synthesis of patulone, a plant metabolite possessing a unique 1,1-diisoprenyl-1H-xanthene-2,9-dione structure, is described. Starting from a 1-fluroxanthone derivative with suitable substitution pattern, the pivotal gem-diisoprenylation was efficiently accomplished by implementing twice the sequence of addition of isoprenyl Grignard reagent to the carbonyl at C9 and anion-accelerated oxy-Cope rearrangement.
Type of Medium:
Online Resource
ISSN:
0936-5214
,
1437-2096
DOI:
10.1055/s-0042-1751395
Language:
German
Publisher:
Georg Thieme Verlag KG
Publication Date:
2023
detail.hit.zdb_id:
2042012-2
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