In:
Angewandte Chemie, Wiley, Vol. 126, No. 25 ( 2014-06-16), p. 6651-6655
Abstract:
The total synthesis of the tunicate metabolite mandelalide A and the correction of its originally assigned stereochemistry are reported. Key features of the convergent, fully stereocontrolled route include the use of a Prins cyclization for the diastereoselective construction of the tetrahydropyran subunit, Rychnovsky–Bartlett cyclization for the preparation of the tetrahydrofuran moiety, Suzuki coupling, Horner–Wadsworth–Emmons macrocyclization, and glycosylation to append the L ‐rhamnose‐derived pyranoside.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v126.25
DOI:
10.1002/ange.201403542
Language:
German
Publisher:
Wiley
Publication Date:
2014
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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