In:
Angewandte Chemie, Wiley, Vol. 126, No. 46 ( 2014-11-10), p. 12740-12744
Abstract:
Construction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer‐targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au‐1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au‐1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS‐mediated signaling pathways, leading to enhanced apoptosis‐inducing efficacy.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v126.46
DOI:
10.1002/ange.201407143
Language:
German
Publisher:
Wiley
Publication Date:
2014
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514305-6
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505872-7
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1479266-7
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506259-7
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