In:
Angewandte Chemie, Wiley, Vol. 127, No. 45 ( 2015-11-02), p. 13434-13438
Abstract:
The first trifluoromethylthiolation and [ 18 F]trifluoromethylthiolation of alkyl electrophiles with in situ generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition‐ metal‐free approach is high yielding, compatible with a variety of functional groups, and operated under mild reaction conditions. The conceptual advantage of this exogenous‐fluoride‐mediated transformation enables unprecedented syntheses of [ 18 F]CF 3 S‐labeled molecules from most commonly used [ 18 F]fluoride ions. The rapid radiochemical reaction time (≤1 min) and high functional‐group tolerance allow access to a variety of aliphatic [ 18 F]CF 3 S compounds in high yields.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v127.45
DOI:
10.1002/ange.201505446
Language:
German
Publisher:
Wiley
Publication Date:
2015
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505872-7
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1479266-7
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506259-7
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