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  • 1
    Online Resource
    Online Resource
    A Behaviorally Evidence-based Method for Computing Spatial Comparisons of Image Scenarios
    Angle Publishing Co., Ltd. ; 2023
    In:  網際網路技術學刊 Vol. 24, No. 5 ( 2023-09), p. 1113-1121
    Details
    In: 網際網路技術學刊, Angle Publishing Co., Ltd., Vol. 24, No. 5 ( 2023-09), p. 1113-1121
    Abstract: 〈p〉Large amounts of noise and a lack of contextual domain knowledge lead to slow and inefficient cross-domain image learning. This paper proposes an image scenario spatial data classification model based on evidence-based behavioral logic, intervenes in image annotation through evidence-based dynamic knowledge graphs, and uses spatial similarity measurement to evaluate the effectiveness and robustness of the method. The results show that: 1) Organizing the dynamic knowledge graphs of contextual domain knowledge by behavioral logic can significantly improve the association efficiency of each model. 2) The calculation method of image scenario space comparison based on behavior evidence can decrypt the implicit knowledge of images and significantly improve the effectiveness of image scenario space interpretation. The research results are helpful to guide the design and implementation of cross-domain image interpretation systems and improve the efficiency of information sharing.〈/p〉 〈p〉 〈/p〉
    Type of Medium: Online Resource
    ISSN: 1607-9264 , 1607-9264
    Uniform Title: A Behaviorally Evidence-based Method for Computing Spatial Comparisons of Image Scenarios
    URL: Article
    DOI: 10.53106/160792642023092405009
    Language: Unknown
    Publisher: Angle Publishing Co., Ltd.
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-11-15)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-11-15)
    Abstract: Tissues and organs undergo structural deterioration and functional decline during aging. DNA damage is considered a major cause of stem cell senescence. Although stem cells develop sophisticated DNA repair systems, when the intrinsic and extrinsic insults exceed the DNA repair capacity, cellular senescence, and age-related diseases inevitably occur. Therefore, the prevention and alleviation of DNA damage is an alternative to DNA repair in attenuating stem cell senescence and preventing age-related diseases. Pre-B-cell leukaemia homeobox 1 (PBX1) participates in maintaining the pluripotency of human embryonic and haematopoietic stem cells. Our recent studies showed that PBX1 promotes hair follicle-derived mesenchymal stem cell (HF-MSC) proliferation, decreases cellular senescence and apoptosis, and enhances induced pluripotent stem cell generation. Whether PBX1 attenuates HF-MSC senescence and apoptosis by alleviating DNA damage or by enhancing DNA repair remains unknown. In this study, we aimed to determine the effects of PBX1 on the intrinsic ROS or extrinsic H 2 O 2 -induced cellular senescence of HF-MSCs. To this end, we generated HF-MSCs overexpressing either PBX1, or poly (ADP-ribose) polymerase 1, or both. Our results showed that PBX1 overexpression attenuates HF-MSC senescence and apoptosis by alleviating reactive oxygen species (ROS)-mediated DNA damage instead of enhancing DNA repair. This is the first study to report that PBX1 attenuates stem cell senescence and apoptosis by alleviating DNA damage. It provides new insight into the mechanism of stem cell senescence and lays the foundation for the development of strategies for age-related disease prevention and treatment, and in particular, hair follicle repair and regeneration.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    DOI: 10.3389/fcell.2021.739868
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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  • 3
    Online Resource
    Online Resource
    Fresnel zone-plate based X-ray microscopy in Zernike phase contrast with sub-50 nm resolution at NSRL
    IOP Publishing ; 2009
    In:  Journal of Physics: Conference Series Vol. 186 ( 2009-09-01), p. 012005-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 186 ( 2009-09-01), p. 012005-
    Type of Medium: Online Resource
    ISSN: 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/186/1/012005
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2009
    detail.hit.zdb_id: 2166409-2
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  • 4
    Online Resource
    Online Resource
    Effects of Interfacial Fluorination on Performance Enhancement of High-k-Based Charge Trap Flash Memory
    IOP Publishing ; 2013
    In:  Japanese Journal of Applied Physics Vol. 52, No. 7R ( 2013-07-01), p. 070201-
    Details
    In: Japanese Journal of Applied Physics, IOP Publishing, Vol. 52, No. 7R ( 2013-07-01), p. 070201-
    Abstract: The effects of interfacial fluorination on the metal/Al 2 O 3 /HfO 2 /SiO 2 /Si (MAHOS) memory structure have been investigated. By comparing MAHOS memories with and without interfacial fluorination, it was identified that the deterioration of the performance and reliability of MAHOS memories is mainly due to the formation of an interfacial layer that generates excess oxygen vacancies at the interface. Interfacial fluorination suppresses the growth of the interfacial layer, which is confirmed by X-ray photoelectron spectroscopy depth profile analysis, increases enhanced program/erase efficiency, and improves data retention characteristics. Moreover, it was observed that fluorination at the SiO–HfO interface achieves a more effective performance enhancement than that at the HfO–AlO interface.
    Type of Medium: Online Resource
    ISSN: 0021-4922 , 1347-4065
    URL: Article
    DOI: 10.7567/JJAP.52.070201
    RVK:
    UA 4210.1
    RVK:
    UA 4210.2
    RVK:
    UA 4210
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2013
    detail.hit.zdb_id: 218223-3
    detail.hit.zdb_id: 797294-5
    detail.hit.zdb_id: 2006801-3
    detail.hit.zdb_id: 797295-7
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  • 5
    Online Resource
    Online Resource
    Table_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 11 ( 2022-1-3)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2022-1-3)
    Abstract: Pancreatic cancer is a highly malignant tumor with a poor survival prognosis. We attempted to establish a robust prognostic model to elucidate the clinicopathological association between lncRNA, which may lead to poor prognosis by influencing m6A modification, and pancreatic cancer. We investigated the lncRNAs expression level and the prognostic value in 440 PDAC patients and 171 normal tissues from GTEx, TCGA, and ICGC databases. The bioinformatic analysis and statistical analysis were used to illustrate the relationship. We implemented Pearson correlation analysis to explore the m6A-related lncRNAs, univariate Cox regression and Kaplan-Meier methods were performed to identify the seven prognostic lncRNAs signatures. We inputted them in the LASSO Cox regression to establish a prognostic model in the TCGA database, verified in the ICGC database. The AUC of the ROC curve of the training set is 0.887, while the validation set is 0.711. Each patient has calculated a risk score and divided it into low-risk and high-risk subgroups by the median value. Moreover, the model showed a robust prognostic ability in the stratification analysis of different risk subgroups, pathological grades, and recurrence events. We established a ceRNA network between lncRNAs and m6A regulators. Enrichment analysis indicated that malignancy-associated biological function and signaling pathways were enriched in the high-risk subgroup and m6A-related lncRNAs target mRNA. We have even identified small molecule drugs, such as Thapsigargin, Mepacrine, and Ellipticine, that may affect pancreatic cancer progression. We found that seven lncRNAs were highly expressed in tumor patients in the GTEx-TCGA database, and LncRNA CASC19/UCA1/LINC01094/LINC02323 were confirmed in both pancreatic cell lines and FISH relative quantity. We provided a comprehensive aerial view between m6A-related lncRNAs and pancreatic cancer’s clinicopathological characteristics, and performed experiments to verify the robustness of the prognostic model.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2021.812785
    DOI: 10.3389/fonc.2021.812785.s001
    DOI: 10.3389/fonc.2021.812785.s002
    DOI: 10.3389/fonc.2021.812785.s003
    DOI: 10.3389/fonc.2021.812785.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 6
    Online Resource
    Online Resource
    Image_1.tiff
    Frontiers Media SA ; 2023
    In:  Frontiers in Immunology Vol. 14 ( 2023-9-18)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-9-18)
    Abstract: Intervertebral disc degeneration (IVDD) is a leading cause of low back pain (LBP). The pathological process of IVDD is associated with inflammatory reactions and extracellular matrix (ECM) disorders. Digoxin is widely used for treating heart failure, and it has been reported to have anti-inflammatory effects. Objective This study is to investigate the role of digoxin in the pathogenesis of intervertebral disc degeneration as well as the involved molecular mechanism, particularly the potential target protein. Methods We exploited a rat needle model to investigate digoxin’s role in intervertebral disc degeneration in vivo . Safranin O staining was used to measure cartilaginous tissue in the intervertebral disc. The morphological changes of intervertebral discs in animal models were determined by Hematoxylin-Eosin (H & amp;E) staining and the pathological score. Primary nucleus pulposus cells (NP cells) from intervertebral discs of patients and murine were used in the present study. Western-Blotting assay, Real-time PCR assay, immunofluorescence staining, and immunochemistry were used to detect the role of digoxin in anti-TNF-α-induced inflammatory effects in vitro . Transfection of siRNA was used to regulate low-density lipoprotein receptor-related protein 4 (LRP4) expression in NP cells to investigate the potential protein target of digoxin. Results Digoxin protected against intervertebral disc degeneration in rat needle models. Digoxin was found to exert its disc-protective effects through at least three different pathways by a) suppressing TNF-α-induced inflammation, b) attenuating ECM destruction, c) significantly promoting ECM anabolism. Additionally, LRP4 was found to be the downstream molecule of digoxin in NP cells for anti-inflammation and regulation of ECM metabolism. The knockdown of LRP4 downregulated the protective effect of digoxin in NP cells. Conclusion These findings suggest that digoxin may be a potential therapeutic agent for intervertebral disc degeneration through anti-catabolism and pro-anabolism. Digoxin might also work as an alternative for other inflammation-related diseases.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2023.1251517
    DOI: 10.3389/fimmu.2023.1251517.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2606827-8
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  • 7
    Online Resource
    Online Resource
    DataSheet_1.zip
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-1-26)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-1-26)
    Abstract: We aimed to determine trends in incidence and survival in patients with gastrointestinal neuroendocrine tumors (GI-NETs) from 1977 to 2016, and then analyze the potential risk factors including sex, age, race, grade, Socioeconomic status (SES), site, and stage. Methods Data were obtained from Surveillance, Epidemiology, and End Results Program (SEER) database. Kaplan-Meier survival analysis, relative survival rates (RSRs), and Cox proportional risk regression model were used to evaluate the relationship between these factors and prognosis. Results Compared with other sites, the small intestine and rectum have the highest incidence, and the appendix and rectum had the highest survival rate. The incidence was higher in males than in females, and the survival rate in males was close to females. Blacks had a higher incidence rate than whites, but similar survival rates. Incidence and survival rates were lower for G3 & amp;4 than for G1 and G2. Age, stage, and grade are risk factors. Conclusions This study described changes in the incidence and survival rates of GI-NETs from 1977 to 2016 and performed risk factor analyses related to GI-NETs.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2023.1079575
    DOI: 10.3389/fonc.2023.1079575.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 8
    Online Resource
    Online Resource
    Enhancing Deepfake Detection With Diversified Self-Blending Images and Residuals
    Institute of Electrical and Electronics Engineers (IEEE) ; 2024
    In:  IEEE Access Vol. 12 ( 2024), p. 46109-46117
    Details
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 12 ( 2024), p. 46109-46117
    Type of Medium: Online Resource
    ISSN: 2169-3536
    URL: Article
    DOI: 10.1109/ACCESS.2024.3382196
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2024
    detail.hit.zdb_id: 2687964-5
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  • 9
    Online Resource
    Online Resource
    Optimization of HfO 2 Growth Process by Atomic Layer Deposition (ALD) for High Performance Charge Trapping Flash Memory Application
    The Electrochemical Society ; 2013
    In:  ECS Transactions Vol. 52, No. 1 ( 2013-03-08), p. 51-56
    Details
    In: ECS Transactions, The Electrochemical Society, Vol. 52, No. 1 ( 2013-03-08), p. 51-56
    Abstract: ALD process of HfO 2 trapping layer with TEMAH and H 2 O as precursors is systematically investigated . By adjusting ALD process parameters of deposition temperature, purge gas cycle mode and purge time, HfO 2 film quality is effectively improved for charge trapping memories(CTM) application. It is found that a large memory window of 4.4V can be obtained for devices with parameters of 150℃ deposition temperature, one TEMAH-one water cycle mode and 5s purge time. Enhancement of memory performance is attributed to the part transformation of chemisorption into physisorption when depositing the trapping layer. For further confirmation of the conclusion, both MHOS and MAHOS structures are employed. The findings provide a guide for future design of CTM.
    Type of Medium: Online Resource
    ISSN: 1938-5862 , 1938-6737
    URL: Article
    DOI: 10.1149/05201.0051ecst
    Language: Unknown
    Publisher: The Electrochemical Society
    Publication Date: 2013
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  • 10
    Online Resource
    Online Resource
    Table_2.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Molecular Biosciences Vol. 8 ( 2021-5-27)
    Details
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 8 ( 2021-5-27)
    Abstract: Colorectal cancer (CRC) is estimated to be one of the most common cancers and the leading cause of cancer-related death worldwide. SOX9 is commonly overexpressed in CRC and participates in drug resistance. In addition, DNA damage repair confers resistance to anticancer drugs. However, the correlation between DNA damage repair and high SOX9 expression is still unclear. In this study, we aimed to investigate the function and the specific underlying mechanism of the SOX9-dependent DNA damage repair pathway in CRC. Methods The expression levels of SOX9 and MMS22L in CRC were examined by immunohistochemistry (IHC) and TCGA analysis. RNA sequencing was conducted in RKO SOX9-deficient cells and RKO shControl cells. Mechanistic studies were performed in CRC cells by modulating SOX9 and MMS22L expression, and we evaluated drug sensitivity and DNA damage repair signaling events. In addition, we investigated the effect of oxaliplatin in tumors with SOX9 overexpression and low expression of MMS22L in vivo . Results Our study showed that SOX9 has a higher expression level in CRC tissues than in normal tissues and predicts poor prognosis in CRC patients. Overexpression and knockdown of SOX9 were associated with the efficacy of oxaliplatin. In addition, SOX9 activity was enriched in the DNA damage repair pathway via regulation of MMS22L expression and participation in DNA double-strand break repair. SOX9 was upregulated and formed a complex with MMS22L, which promoted the nuclear translocation of MMS22L upon oxaliplatin treatment. Moreover, the x enograft assay results showed that oxaliplatin abrogated tumor growth from cells with MMS22L downregulation in mice. Conclusions In CRC, activation of the SOX9-MMS22L-dependent DNA damage pathway is a core pathway regulating oxaliplatin sensitivity. Targeting this pathway in oxaliplatin-resistant CRC cells is a promising therapeutic option.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmolb.2021.646542
    DOI: 10.3389/fmolb.2021.646542.s001
    DOI: 10.3389/fmolb.2021.646542.s002
    DOI: 10.3389/fmolb.2021.646542.s003
    DOI: 10.3389/fmolb.2021.646542.s004
    DOI: 10.3389/fmolb.2021.646542.s005
    DOI: 10.3389/fmolb.2021.646542.s006
    DOI: 10.3389/fmolb.2021.646542.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2814330-9
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