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  • 1
    Online Resource
    Online Resource
    Angle Publishing Co., Ltd. ; 2023
    In:  電腦學刊 Vol. 34, No. 6 ( 2023-12), p. 133-143
    In: 電腦學刊, Angle Publishing Co., Ltd., Vol. 34, No. 6 ( 2023-12), p. 133-143
    Abstract: 〈 p 〉 In the domain of cloud computing and network resource virtualization, existing fusion techniques for containers and virtual machines suffer from high energy consumption, inflexible scheduling requirements, and suboptimal resource utilization. This study critically examined the current methods, accounted for the contemporary requirements, and developed a novel strategy aimed at maximizing resource utilization while minimizing energy consumption. Comprehensive experiments illustrate the superiority of our approach over state-of-the-art fusion strategies such as Kubernetes+Kubevirt and OpenStack+Kubernetes, demonstrating significant reductions in energy consumption, improved resource utilization, and enhanced system performance. 〈 /p 〉 〈 p 〉 & nbsp; 〈 /p 〉
    Type of Medium: Online Resource
    ISSN: 1991-1599 , 1991-1599
    Uniform Title: Mitigating Cloud Computing Virtualization Performance Problems with an Upgraded Logical Convergence Strategy
    Language: Unknown
    Publisher: Angle Publishing Co., Ltd.
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Endocrinology Vol. 12 ( 2021-3-11)
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 12 ( 2021-3-11)
    Abstract: Preeclampsia (PE) is a serious pregnancy-related disease, and patients usually present with a high inflammatory response. Previous studies have suggested that aspirin (ASP) may have a role in alleviating the pathogenesis of preeclampsia. However, whether ASP can improve kidney damage and the mechanism for improving it is currently unclear. Here we optimized a lipopolysaccharide (LPS)-induced PE mouse model to identify the role of ASP in renal protection. We found that ASP treatment ameliorated LPS-induced renal failure and pathological changes, the tubular injury was significantly attenuated by ASP. Administration of ASP decreased the renal expression of pro-inflammatory factors, resulting in reduced kidney inflammation. The number of GALECTIN-3-positive cells was reduced, and the up-regulation of IL-6 and TNF-α was decreased. In addition, ASP also suppressed renal cell apoptosis and oxidative stress. An in vitro study indicated that ASP relieved LPS-induced HK-2 cell damage by inhibiting WNT5A/NF-κB signaling. Collectively, our data suggest that ASP is a useful therapeutic option for PE-related kidney injury.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2592084-4
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2020
    In:  Frontiers in Cell and Developmental Biology Vol. 8 ( 2020-9-11)
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 8 ( 2020-9-11)
    Type of Medium: Online Resource
    ISSN: 2296-634X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2737824-X
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  • 4
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-11-29)
    Abstract: Animal personality refers to individual behavioral and physiological differences that are consistent over time and across context. Recently, the fish personality has gained increasing attention, especially from the perspective of aquaculture production. Here, we used an important aquaculture species, black rockfish Sebastes schlegelii , as the target animal, and conducted a series of experiments to explore the relationships among fish boldness, aggressiveness, locomotor activity, opercular beat rate, standard metabolic rate, and cortisol level. Generally, the results showed that the boldness of black rockfish was significantly, positively correlated with fish aggressiveness, stressed locomotor activity, and standard metabolic rate, while was negatively correlated with stressed opercular beat rate. Bold fish had significantly higher aggressiveness, standard metabolic rate, and stressed locomotor activity but lower stressed opercular beat rate. However, there were no significant correlations between boldness and basal locomotor activity or between boldness and basal cortisol level. These results preliminarily constructed the behavioral and physiological spectrum of black rockfish in the context of fish personality and clearly indicated that the boldness could be used as a discrimination tool to predict fish aggressiveness and metabolic rate, which may have valuable applications for decreasing fish harmful aggression and increasing fish welfare in the aquaculture industry.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2757748-X
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  • 5
    Online Resource
    Online Resource
    American Institute of Mathematical Sciences (AIMS) ; 2022
    In:  Discrete & Continuous Dynamical Systems - B Vol. 27, No. 4 ( 2022), p. 1927-
    In: Discrete & Continuous Dynamical Systems - B, American Institute of Mathematical Sciences (AIMS), Vol. 27, No. 4 ( 2022), p. 1927-
    Abstract: 〈p style='text-indent:20px;'〉In this paper, we study the following Kirchhoff-type fractional Schrödinger system with critical exponent in 〈inline-formula〉〈tex-math id="M1"〉\begin{document}$ \mathbb{R}^N $\end{document}〈/tex-math〉〈/inline-formula〉:〈/p〉〈p style='text-indent:20px;'〉〈disp-formula〉 〈label/〉 〈tex-math id="FE1"〉 \begin{document}$ \begin{equation*} \begin{cases} \left(a_{1}+b_{1}\int_{\mathbb{R}^N}|(-\Delta)^{\frac{s}{2}}u|^2dx\right)(-\Delta)^{s}u+u = \mu_1|u|^{2^*_s-2}u +\frac{\alpha\gamma}{2^*_s}|u|^{\alpha-2}u|v|^{\beta}+k|u|^{p-1}u,\\ \left(a_{2}+b_{2}\int_{\mathbb{R}^N}|(-\Delta)^{\frac{s}{2}}v|^2dx\right)(-\Delta)^{s}v+v = \mu_2|v|^{2^*_s-2}v+ \frac{\beta\gamma}{2^*_s}|u|^{\alpha}|v|^{\beta-2}v+k|v|^{p-1}v,\\ \end{cases} \end{equation*} $\end{document} 〈/tex-math〉〈/disp-formula〉〈/p〉〈p style='text-indent:20px;'〉where 〈inline-formula〉〈tex-math id="M2"〉\begin{document}$ (-\Delta)^{s} $\end{document}〈/tex-math〉〈/inline-formula〉 is the fractional Laplacian, 〈inline-formula〉〈tex-math id="M3"〉\begin{document}$ 0〈s〈1 $\end{document}〈/tex-math〉〈/inline-formula〉, 〈inline-formula〉〈tex-math id="M4"〉\begin{document}$ N〉2s, $\end{document}〈/tex-math〉〈/inline-formula〉 〈inline-formula〉〈tex-math id="M5"〉\begin{document}$ 2_{s}^{\ast} = 2N/(N-2s) $\end{document}〈/tex-math〉〈/inline-formula〉 is the fractional critical Sobolev exponent, 〈inline-formula〉〈tex-math id="M6"〉\begin{document}$ \mu_{1},\mu_{2},\gamma, k〉0 $\end{document}〈/tex-math〉〈/inline-formula〉, 〈inline-formula〉〈tex-math id="M7"〉\begin{document}$ \alpha+\beta = 2_{s}^{\ast},\ 1〈p〈2_{s}^{\ast}-1 $\end{document}〈/tex-math〉〈/inline-formula〉, 〈inline-formula〉〈tex-math id="M8"〉\begin{document}$ a_{i},b_{i}\geq 0, $\end{document}〈/tex-math〉〈/inline-formula〉 with 〈inline-formula〉〈tex-math id="M9"〉\begin{document}$ a_{i}+b_{i}〉0,\ \ i = 1,2 $\end{document}〈/tex-math〉〈/inline-formula〉. By using appropriate transformation, we first get its equivalent system which may be easier to solve:〈/p〉〈p style='text-indent:20px;'〉〈disp-formula〉 〈label/〉 〈tex-math id="FE2"〉 \begin{document}$ \begin{equation*} \begin{cases} (-\Delta)^{s}u+u = \mu_1|u|^{2^*_s-2}u+\frac{\alpha\gamma}{2^*_s}|u|^{\alpha-2}u|v|^{\beta}+k|u|^{p-1}u, \ \ x\in \mathbb{R}^N, \\ (-\Delta)^{s}v+v = \mu_2|v|^{2^*_s-2}v+\frac{\beta\gamma}{2^*_s}|u|^{\alpha}|v|^{\beta-2}v+k|v|^{p-1}v,\ \ x\in \mathbb{R}^N,\\ \lambda_{1}^{s}-a_{1}-b_{1}\lambda_{1}^{\frac{N-2s}{2}}\int_{\mathbb{R}^N}|(-\Delta)^{\frac{s}{2}}u|^2dx = 0, \ \ \lambda_{1}\in \mathbb{R}^+,\\ \lambda_{2}^{s}-a_{2}-b_{2}\lambda_{2}^{\frac{N-2s}{2}}\int_{\mathbb{R}^N}|(-\Delta)^{\frac{s}{2}}v|^2dx = 0, \ \ \lambda_{2}\in \mathbb{R}^+. \end{cases} \end{equation*} $\end{document} 〈/tex-math〉〈/disp-formula〉〈/p〉〈p style='text-indent:20px;'〉Then, by using the mountain pass theorem, together with some classical arguments from Brézis and Nirenberg, we obtain the existence of solutions for the new system under suitable conditions. Finally, based on the equivalence of two systems, we get the existence of solutions for the original system. Our results give improvement and complement of some recent theorems in several directions.〈/p〉
    Type of Medium: Online Resource
    ISSN: 1531-3492 , 1553-524X
    Language: Unknown
    Publisher: American Institute of Mathematical Sciences (AIMS)
    Publication Date: 2022
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2022
    In:  IEEE Transactions on Power Electronics Vol. 37, No. 10 ( 2022-10), p. 12316-12326
    In: IEEE Transactions on Power Electronics, Institute of Electrical and Electronics Engineers (IEEE), Vol. 37, No. 10 ( 2022-10), p. 12316-12326
    Type of Medium: Online Resource
    ISSN: 0885-8993 , 1941-0107
    RVK:
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2022
    detail.hit.zdb_id: 2034323-1
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  • 7
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-3-29)
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-3-29)
    Abstract: Background: The nuclear receptor Nur77 has been demonstrated to play a vital role in the inflammatory response and cellular metabolisms, and its ligands exhibit efficacy in the treatment of inflammation-related diseases (e.g., improving mouse acute lung injury (ALI) and obesity. Recently, ω-3 polyunsaturated fatty acid-ethanolamine derivatives (ω-3 PUFA-EAs), including DPA-EA and DHA-EA, have been reported as new Nur77-targeting anti-inflammatory agents. However, the lipid-lowering effect of ω-3 PUFA-EAs is still unknown, and lipid profile changes induced by Nur77-targeting anti-inflammatory agents also remain unclear. Objective: This study aimed to evaluate the lipid-lowering effect and the underlying mechanism of DPA-EA acting as Nur77-targeting anti-inflammatory agents. It also aimed to investigate the in vitro and in vivo lipid-lowering effects of the DPA-EA and DHA-EA mixture prepared from algae oil. Methods: The in vitro lipid-lowing effect of DPA-EA and its mixture with DHA-EA was first evaluated in palmitic acid-stimulated HepG2 Cells. To confirm the lipid-lowering effect and explore the underlying mechanism, we performed untargeted lipidomic analysis using ultra-performance liquid chromatography/triple quadrupole-time-of-flight (TOF) mass spectrometry coupled with multivariate statistical analysis, with another Nur77-targeting anti-inflammatory compound Celastrol (Cel) as a reference. Finally, we examined the anti-obesity effect of the DPA-EA and DHA-EA mixture synthesized from algae oil in a high-fat diet (HFD)-fed mice model. Results: DPA-EA significantly alleviated lipid accumulation with lower toxicity than Celastrol. Nur77-targeting compounds DPA-EA and Celastrol could simultaneously reduce 14 lipids (9 TGs, 2 PCs, 1 PA, 1 SM, and 1 LacCer) and increase 13 lipids (4 DGs, 6 LPEs, 2 PEs, and 1PC) in Pal-stimulated HepG2 cells. However, Cer lipids were more sensitive to DPA-EA, while the over-downregulation of SM lipids might be associated with the off-target toxicity of Celastrol. The mixture of DPA-EA and DHA-EA synthesized from algae oil could significantly decrease TG, TC, and LDL levels and increase HDL levels in HFD-fed mice, exerting an excellent anti-obesity effect. Conclusion: Nur77-targeting anti-inflammatory compound DAP-EA could promote the hydrolysis of PEs and TGs to ameliorate lipid accumulation. The DPA-EA and DHA-EA mixture prepared from algae oil might be a potential therapeutic agent for obesity and other inflammation-related diseases.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Pharmacology Vol. 11 ( 2021-4-13)
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 11 ( 2021-4-13)
    Abstract: Sepsis-induced myocardial dysfunction is a major contributor to the poor outcomes of septic shock. As an add-on with conventional sepsis management for over 15 years, the effect of Xuebijing injection (XBJ) on the sepsis-induced myocardial dysfunction was not well understood. The material basis of Xuebijing injection (XBJ) in managing infections and infection-related complications remains to be defined. A murine cecal ligation and puncture (CLP) model and cardiomyocytes in vitro culture were adopted to study the influence of XBJ on infection-induced cardiac dysfunction. XBJ significantly improved the survival of septic-mice and rescued cardiac dysfunction in vivo . RNA-seq revealed XBJ attenuated the expression of proinflammatory cytokines and related signalings in the heart which was further confirmed on the mRNA and protein levels. Xuebijing also protected cardiomyocytes from LPS-induced mitochondrial calcium ion overload and reduced the LPS-induced ROS production in cardiomyocytes. The therapeutic effect of XBJ was mediated by the combination of paeoniflorin and hydroxysafflor yellow A (HSYA) (C0127-2). C0127-2 improved the survival of septic mice, protected their cardiac function and cardiomyocytes while balancing gene expression in cytokine-storm-related signalings, such as TNF-α and NF-κB. In summary, Paeoniflorin and HSYA are key active compounds in XBJ for managing sepsis, protecting cardiac function, and controlling inflammation in the cardiac tissue partially by limiting the production of IL-6, IL-1β, and CXCL2.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Genetics Vol. 11 ( 2021-1-15)
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 11 ( 2021-1-15)
    Abstract: The emerald ash borer (EAB), Agrilus planipennis , is a highly destructive quarantine pest. The olfactory and visual systems of A. planipennis play different but critical roles at newly emerged and sexually mature stages; however, the molecular basis underlying these differences remain unclear. Consequently, based on deep transcriptome sequencing, we evaluated the expression levels of chemosensory-related proteins and opsins at the two developmental stages of A. planipennis . We found 15 new chemosensory-related genes in our transcriptome assembly compared with the previous genome assembly, including 6 that code for odorant-binding proteins (OBPs) and 9 for chemosensory proteins (CSPs). The expression of several chemosensory-related genes ( OBP7, OBP10, CSP1 , and CSP12 ) differed markedly between newly emerged and sexually mature A. planipennis . We also found that the expression of UV opsin 2 and LW opsin 1 was higher in sexually mature male A. planipennis , which may be associated with their strong visual mate detection ability. This study forms the basis for further investigation of the chemosensory and visual system of A. planipennis , and these differentially expressed genes between newly emerged and sexually mature stages may serve as targets for the management of this destructive forest pest after sexual maturity.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 10
    In: Translational Lung Cancer Research, AME Publishing Company, Vol. 9, No. 3 ( 2020-6), p. 646-658
    Type of Medium: Online Resource
    ISSN: 2218-6751 , 2226-4477
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2020
    detail.hit.zdb_id: 2754335-3
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