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  • 1
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    Figure 5 from: Xiong S, Engel MS, Xiao L, Ren D (2021) New archidermapteran earwigs (Dermaptera) from the Middle Jurassic of Inner Mongolia, China. ZooKeys 1065: 125-139. https://doi.org/10.3897/zookeys.1065.72720
    Pensoft Publishers ; 2021
    In:  ZooKeys Vol. 1065 ( 2021-10-26), p. 125-139
    Details
    In: ZooKeys, Pensoft Publishers, Vol. 1065 ( 2021-10-26), p. 125-139
    Abstract: Two new species of Archidermaptera are described and figured from the Middle Jurassic Jiulonghsan Formation of Daohugou, Inner Mongolia, China. Aneuroderma oiodes gen. & amp; sp. nov. is described in the family Protodiplatyidae and Sinopalaeodermata concavum sp. nov. is established in the family Dermapteridae. Both new species share the typical characters of the extinct suborder Archidermaptera (e.g., pentamerous metatarsi, filiform and multimerous cerci, externalized ovipositor). Aneuroderma gen. nov. is compared with other genera of the Protodiplatyidae, while S. concavum sp. nov. allows us to emend the diagnosis of the genus Sinopalaeodermata . We briefly discuss the diversity of Archidermaptera and challenges to understanding relationships among this mid-Mesozoic diversity.
    Type of Medium: Online Resource
    ISSN: 1313-2970 , 1313-2989
    URL: Article
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    URL: Article
    DOI: 10.3897/zookeys.1065.72720
    DOI: 10.3897/zookeys.1065.72720.figure1
    DOI: 10.3897/zookeys.1065.72720.figure2
    DOI: 10.3897/zookeys.1065.72720.figure3
    DOI: 10.3897/zookeys.1065.72720.figure4
    DOI: 10.3897/zookeys.1065.72720.figure5
    Language: Unknown
    Publisher: Pensoft Publishers
    Publication Date: 2021
    detail.hit.zdb_id: 2445640-8
    SSG: 12
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  • 2
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    Figure 5 from: Chen G, Xiao L, Liang J, Shih C, Ren D (2021) A new cockroach (Blattodea, Corydiidae) with pectinate antennae from mid-Cretaceous Burmese amber. ZooKeys 1060: 155-169. https://doi.org/10.3897/zookeys.1060.67216
    Pensoft Publishers ; 2021
    In:  ZooKeys Vol. 1060 ( 2021-09-24), p. 155-169
    Details
    In: ZooKeys, Pensoft Publishers, Vol. 1060 ( 2021-09-24), p. 155-169
    Abstract: A new species of fossil cockroach, Fragosublatta pectinata gen. et sp. nov. , is described from mid-Cretaceous Burmese amber. The new species is assigned to the family Corydiidae based on the following combination of characters: pronotum with tubercles, tegmina obovate with smallish anal region and spinules on the antero-ventral margin of the front femur (type C1). The new species is the second reported cockroach with ramified antennae. This finding broadens the diversity of Blattodea in mid-Cretaceous Burmese amber and provides further evidence of convergent evolution for antennal structures among different insect lineages.
    Type of Medium: Online Resource
    ISSN: 1313-2970 , 1313-2989
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3897/zookeys.1060.67216
    DOI: 10.3897/zookeys.1060.67216.figure1
    DOI: 10.3897/zookeys.1060.67216.figure2
    DOI: 10.3897/zookeys.1060.67216.figure3
    DOI: 10.3897/zookeys.1060.67216.figure4
    DOI: 10.3897/zookeys.1060.67216.figure5
    Language: Unknown
    Publisher: Pensoft Publishers
    Publication Date: 2021
    detail.hit.zdb_id: 2445640-8
    SSG: 12
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  • 3
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    Table_4.XLS
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-5-13)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-5-13)
    Abstract: Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Endothelial progenitor cell (EPC)-derived exosomes have been found to be effective in alleviating MI, while the detailed mechanisms remain unclear. The present study aimed to determine the protective effects of EPC-derived exosomal miR-1246 and miR-1290 on MI-induced injury and to explore the underlying molecular mechanisms. The exosomes were extracted from EPCs; gene expression levels were determined by quantitative real-time PCR, and protein expression levels were determined by western blot and immunofluorescence staining, respectively. The angiogenesis and proliferation of human cardiac fibroblasts (HCFs) were determined by tube formation assay and immunofluorescence staining of PKH67, respectively. Luciferase reporter, CHIP, and EMSA assays determined the interaction between miR-1246/1290 and the targeted genes (EFL5 and SP1). The protective effects of miR-1246/1290 on MI were evaluated in a rat model of MI. EPC-derived exosomes significantly upregulated miR-1246 and miR-1290 expression and promoted phenotypic changes of fibroblasts to endothelial cells, angiogenesis, and proliferation in HCFs. Exosomes from EPCs with miR-1246 or miR-1290 mimics transfection promoted phenotypic changes of fibroblasts to endothelial cells and angiogenesis in HCFs, while exosomes from EPCs with miR-1246 or miR-1290 knockdown showed opposite effects in HCFs. Mechanistically, miR-1246 and miR-1290 from EPC-derived exosomes induced upregulation of ELF5 and SP1, respectively, by targeting the promoter regions of corresponding genes. Overexpression of both ELF5 and SP1 enhanced phenotypic changes of fibroblasts to endothelial cells and angiogenesis in HCFs pretreated with exosomes from EPCs with miR-1246 or miR-1290 mimics transfection, while knockdown of both EFL5 and SP1 exerted the opposite effects in HCFs. Both ELF5 and SP1 can bind to the promoter of CD31, leading to the upregulation of CD31 in HCFs. Furthermore, in vivo animal studies showed that exosomes from EPCs with miR-1246 or miR-1290 overexpression attenuated the MI-induced cardiac injury in the rats and caused an increase in ELF5, SP1, and CD31 expression, respectively, but suppressed α-SMA expression in the cardiac tissues. In conclusion, our study revealed that miR-1246 and miR-1290 in EPC-derived exosomes enhanced in vitro and in vivo angiogenesis in MI, and these improvements may be associated with amelioration of cardiac injury and cardiac fibrosis after MI.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
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    DOI: 10.3389/fcell.2021.647763
    DOI: 10.3389/fcell.2021.647763.s001
    DOI: 10.3389/fcell.2021.647763.s002
    DOI: 10.3389/fcell.2021.647763.s003
    DOI: 10.3389/fcell.2021.647763.s004
    DOI: 10.3389/fcell.2021.647763.s005
    DOI: 10.3389/fcell.2021.647763.s006
    DOI: 10.3389/fcell.2021.647763.s007
    DOI: 10.3389/fcell.2021.647763.s008
    DOI: 10.3389/fcell.2021.647763.s009
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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  • 4
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    Sequential CAR T-Cell Therapy After Autologous Stem Cell Transplantation for the Treatment of Relapsed/Refractory Intravascular Large B-Cell Lymphoma With Central Nervous System Involvement: A Case Report
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-4-28)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-4-28)
    Abstract: Intravascular large B-cell lymphoma (IVLBCL) is a rare, aggressive, large B-cell non-Hodgkin’s lymphoma. The prognosis of IVLBCL in patients with central nervous system recurrence after first-line chemotherapy treatment is extremely poor. Among immunotherapies, chimeric antigen receptor (CAR) T-cell immunotherapy has been recently found to be a highly effective treatment for B-cell lymphoma, especially for relapsed or refractory diffuse large B-cell lymphoma. However, no guidelines are available that provide a clear consensus regarding the management of patients with relapsed/refractory IVLBCL. Here, we report, for the first time, the use of autologous hematopoietic stem cell transplantation (ASCT) and CAR T-cell therapy in a patient with relapsed/refractory IVLBCL. Case Presentation A 42‐year‐old woman was diagnosed with IVLBCL based on liver biopsy and developed central nervous system (CNS) progression. The patient received ASCT combined with murine monoclonal anti-CD19 and anti-CD22 CAR T-cell therapy. She achieved complete remission for 22 months so far with negative minimal residual disease and continues to be followed up. Conclusion ASCT combined with CAR T-cell therapy was the best choice for treatment of relapsed/refractory IVLBCL, as it allowed the achievement of a lasting complete remission.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.817969
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 5
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    Pump-Suppressed Nondegenerate Four-Wave Mixing in a Highly Nonlinear Photonic Crystal Fiber Sagnac Loop
    Institute of Electrical and Electronics Engineers (IEEE) ; 2008
    In:  IEEE Photonics Technology Letters Vol. 20, No. 24 ( 2008-12), p. 2129-2131
    Details
    In: IEEE Photonics Technology Letters, Institute of Electrical and Electronics Engineers (IEEE), Vol. 20, No. 24 ( 2008-12), p. 2129-2131
    Type of Medium: Online Resource
    ISSN: 1041-1135 , 1941-0174
    URL: Article
    DOI: 10.1109/LPT.2008.2007131
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2008
    detail.hit.zdb_id: 2025386-2
    detail.hit.zdb_id: 246805-0
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  • 6
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    DataSheet_1.pdf
    Frontiers Media SA ; 2023
    In:  Frontiers in Plant Science Vol. 13 ( 2023-1-16)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2023-1-16)
    Abstract: Miscanthus , a promising bioenergy plant, has a high biomass yield with high cellulose content suitable for biofuel production. However, harsh climatic and poor soil conditions, such as barren lands or abandoned mines, pose a challenge to the survival and yield of Miscanthus feedstock on the marginal land. The selection from the interspecific hybrids of Miscanthus might combine high survival rates and high yield, which benefits energy crop development in multi-stressful environments. A total of 113 F 1 hybrids between Miscanthus sacchariflorus and M. lutarioriparius together with the parents were planted and evaluated for multiple morphological and physiological traits on the mine land of the Loess Plateau of China. The majority of hybrids had higher establishment rates than M. sacchariflorus while M. lutarioriparius failed to survive for the first winter. Nearly all hybrid genotypes outperformed M. lutarioriparius for yield-related traits including plant height, tiller number, tiller diameter, and leaf area. The average biomass of the hybrids was 20 times higher than that of surviving parent, M. sacchariflorus . Furthermore, the photosynthetic rates and water use efficiency of the hybrids were both significantly higher than those of the parents, which might be partly responsible for their higher yield. A total of 29 hybrids with outstanding traits related to yield and stress tolerance were identified as candidates. The study investigated for the first time the hybrids between local individuals of M. sacchariflorus and high-biomass M. lutarioriparius , suggesting that this could be an effective approach for high-yield energy crop development on vast of marginal lands.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2022.1017712
    DOI: 10.3389/fpls.2022.1017712.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 7
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    OR-009 The expression and roles of lncRNAs in the regeneration of skeletal muscle contusion
    Universite Catholique de Louvain ; 2018
    In:  Exercise Biochemistry Review Vol. 1, No. 2 ( 2018-10-03)
    Details
    In: Exercise Biochemistry Review, Universite Catholique de Louvain, Vol. 1, No. 2 ( 2018-10-03)
    Abstract: Objective In recent years, Accumulating evidence from myoblast differentiation in vitro, cardiotoxin (CTX)-mediated injury or mdx mice suggested that some lncRNAs such as Malat1, H19, linc-MD1, linc-YY1, Sirt1 AS and lnc-mg may modulate myogenesis and muscle regeneration. However, the change of lncRNAs in skeletal muscle contusion and their possible roles are still unclear. We hypothesize that the lncRNAs may be involved in the repair of skeletal muscle contusion. Methods Forty C57BL/6 male mice were randomly divided into two groups, uninjured control group (group C) and muscle contusion group (group S). The mice of group S suffered from contusion injury. All the mice were killed to harvest gastrocnemius at 3, 6, 12 and 24 days post-injury. The gene expression were detected by PCR technique. Gastrocnemius were stained with H & E to evaluate the general morphology. Data were analyzed by One-way analysis of variance, with statistical significance being set at p ≤ 0.05. Results The expression levels of linc-MD1 and Sirt1 AS were significantly higher than that of the uninjured control group at 3, 6 and 12 days post-injury (p 〈 0.01). And Malat1 was highly expressed in the skeletal muscle of the muscle contusion group at 3 days post-injury and continuously up-regulated at 6 days (p 〈 0.01). Moreover, linc-YY1 and H19 were all elevated significantly at 6 days (all p 〈 0.01), but their gene expression levels did not change significantly at 3, 12 and 24 days post-injury, as compared to the uninjured control group. Furthermore, lnc-mg mRNA level did not change significantly in the whole process of regeneration after muscle contusion except the time point of 12 days post-injury which decreased significantly (p 〈 0.01). The expression of myogenic regulatory factors (MyoD, myogenin, myf5, myf6) were studied, they were all elevated significantly at 3 and 6 days (all p 〈 0.01; except myogenin ), and returned to normal at 24 days post-injury, as compared to the uninjured control group. Meanwhile, Pearson correlations showed that there was an correlation between lincRNAs and myogenic regulatory factors mentioned above. Conclusions The expression of myogenic regulatory factors increased significantly after muscle contusion. Meanwhile, varieties of lncRNAs (Malat1, H19, lnc-mg, linc-MD1, linc-YY1, Sirt1 AS) were also up-regulated. Moreover, there was correlation between lncRNAs and myogenic regulatory factors for skeletal muscle regeneration. These results suggest that lncRNAs may play important roles in the regeneration of skeletal muscle contusion.
    Type of Medium: Online Resource
    ISSN: 2593-7588
    URL: Issue
    URL: Article
    DOI: 10.14428/ebr.v1i2
    DOI: 10.14428/ebr.v1i2.8693
    Language: Unknown
    Publisher: Universite Catholique de Louvain
    Publication Date: 2018
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  • 8
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    PL-003 BMSCs transplantation aggravate inflammation, oxidative stress, fibrosis and impair skeletal muscle regeneration
    Universite Catholique de Louvain ; 2018
    In:  Exercise Biochemistry Review Vol. 1, No. 1 ( 2018-09-29)
    Details
    In: Exercise Biochemistry Review, Universite Catholique de Louvain, Vol. 1, No. 1 ( 2018-09-29)
    Abstract: Objective Skeletal muscle contusion is one of the most common muscle injury in sports medicine and traumatology. Bone marrow mesenchymal stem cells (BMSCs) transplantation is a promising strategy for muscle regeneration. However, the roles of BMSCs, especially the mechanisms involved, in the regeneration of contused skeletal muscle are still not fully recognized. The aim of the study is to evaluate the potential of BMSCs transplantation for muscle regeneration and mechanisms involved after contusion. Methods Ninety-nine C57BL/6J mice were divided into three groups: control group (n=11), muscle contusion and BMSCs treated group (n=44), muscle contusion and sham treated group (n=44). BMSCs were immediately transplanted into gastrocnemius muscles (GMs) following direct contusion. At different time points (3, 6, 12 and 24 days) post-injury, the animals were killed and then GMs were harvested. Morphological and gene expression analyses were used to elevate the effect of BMSCs transplantation and mechanisms involved. Results The results indicate that BMSCs transplantation impairs muscle regeneration, as well as more fibrotic scar formation after skeletal muscle contusion. Furthermore, macrophages, inflammatory cytokines, chemokines, matrix metalloproteinases and oxidative stress related enzymes were significantly increased after BMSCs transplantation. These results suggest that BMSCs transplantation impairs skeletal muscle regeneration and that macrophages, inflammatory cytokines, chemokines, matrix metalloproteinases and oxidative stress related enzymes may be involved in the process. Conclusions BMSCs transplantation aggravates inflammation, oxidative stress and fibrosis, and impairs skeletal muscle regeneration, which shed new light on the role of BMSCs in regenerative medicine and cautions the application of BMSCs for muscle injury.
    Type of Medium: Online Resource
    ISSN: 2593-7588
    URL: Issue
    URL: Article
    DOI: 10.14428/ebr.v1i1
    DOI: 10.14428/ebr.v1i1.8073
    Language: Unknown
    Publisher: Universite Catholique de Louvain
    Publication Date: 2018
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  • 9
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    Effect of Post Placement on the Restoration of Endodontically Treated Teeth: A Systematic Review
    Quintessence Publishing ; 2015
    In:  The International Journal of Prosthodontics Vol. 28, No. 5 ( 2015-09), p. 475-483
    Details
    In: The International Journal of Prosthodontics, Quintessence Publishing, Vol. 28, No. 5 ( 2015-09), p. 475-483
    Type of Medium: Online Resource
    ISSN: 0893-2174
    URL: Article
    DOI: 10.11607/ijp.4120
    RVK:
    XA 50080
    Language: Unknown
    Publisher: Quintessence Publishing
    Publication Date: 2015
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  • 10
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    Table_1.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-11-1)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-11-1)
    Abstract: Background: Ferroptosis is an iron-dependent programmed cell death (PCD) form that plays a crucial role in tumorigenesis and might affect the antitumor effect of radiotherapy and immunotherapy. This study aimed to investigate distinct ferroptosis-related genes, their prognostic value and their relationship with immunotherapy in patients with head and neck squamous cell carcinoma (HNSCC). Methods: The differentially expressed ferroptosis-related genes in HNSCC were filtered based on multiple public databases. To avoid overfitting and improve clinical practicability, univariable, least absolute shrinkage and selection operator (LASSO) and multivariable Cox algorithms were performed to construct a prognostic risk model. Moreover, a nomogram was constructed to forecast individual prognosis. The differences in tumor mutational burden (TMB), immune infiltration and immune checkpoint genes in HNSCC patients with different prognoses were investigated. The correlation between drug sensitivity and the model was firstly analyzed by the Pearson method. Results: Ten genes related to ferroptosis were screened to construct the prognostic risk model. Kaplan-Meier (K-M) analysis showed that the prognosis of HNSCC patients in the high-risk group was significantly lower than that in the low-risk group ( P & lt; 0.001), and the area under the curve (AUC) of the 1-, 3- and 5-year receiver operating characteristic (ROC) curve increased year by year (0.665, 0.743, and 0.755). The internal and external validation further verified the accuracy of the model. Then, a nomogram was build based on the reliable model. The C-index of the nomogram was superior to a previous study (0.752 vs. 0.640), and the AUC (0.729 vs. 0.597 at 1 year, 0.828 vs. 0.706 at 3 years and 0.853 vs. 0.645 at 5 years), calibration plot and decision curve analysis (DCA) also shown the satisfactory predictive capacity. Furthermore, the TMB was revealed to be positively correlated with the risk score in HNSCC patients ( R = 0.14; P & lt; 0.01). The differences in immune infiltration and immune checkpoint genes were significant ( P & lt; 0.05). Pearson analysis showed that the relationship between the model and the sensitivity to antitumor drugs was significant ( P & lt; 0.05). Conclusion: Our findings identified potential novel therapeutic targets, providing further potential improvement in the individualized treatment of patients with HNSCC.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
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    DOI: 10.3389/fcell.2021.739011
    DOI: 10.3389/fcell.2021.739011.s001
    DOI: 10.3389/fcell.2021.739011.s002
    DOI: 10.3389/fcell.2021.739011.s003
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    DOI: 10.3389/fcell.2021.739011.s005
    DOI: 10.3389/fcell.2021.739011.s006
    DOI: 10.3389/fcell.2021.739011.s007
    DOI: 10.3389/fcell.2021.739011.s008
    DOI: 10.3389/fcell.2021.739011.s009
    DOI: 10.3389/fcell.2021.739011.s010
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
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