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  • 1
    Online Resource
    Online Resource
    Dynamic changes in the level of WT1 as an MRD marker to predict the therapeutic outcome of patients with AML with and without allogeneic stem cell transplantation
    Spandidos Publications ; 2019
    In:  Molecular Medicine Reports ( 2019-06-28)
    Details
    In: Molecular Medicine Reports, Spandidos Publications, ( 2019-06-28)
    Type of Medium: Online Resource
    ISSN: 1791-2997 , 1791-3004
    URL: Journal
    URL: Article
    DOI: 10.3892/mmr
    DOI: 10.3892/mmr.2019.10440
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2469505-1
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  • 2
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    Table_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Cardiovascular Medicine Vol. 8 ( 2021-9-27)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-9-27)
    Abstract: Background: The prognosis of patients with multiple myeloma (MM) is variable and partly depends on their cardiovascular status. The presence of arrhythmias can lead to worse outcomes. Therefore, this study aimed to evaluate the potential of heart rate (HR) and hypertension in predicating the outcomes of MM patients. Methods: This study retrospectively enrolled patients with MM between January 1, 2010, and December 31, 2018, at the First Affiliated Hospital of Xi'an Jiaotong University. The endpoint was all-cause mortality. The Pearson's chi-square test was used to assess the association between hypertension and outcomes. Univariate and multivariate Cox proportional hazards models were developed to evaluate the relationship between HR and all-cause mortality. Results: A total of 386 patients were included. The mean HR was 83.8 ± 23.1 beats per minute (bpm). Patients with HR & gt;100 bpm had a higher all-cause mortality (79.4%, 50/63) than those with 60 ≤ HR ≤ 100 bpm (39.9%, 110/276) and & lt;60 bpm (19.1%, 9/47) ( p & lt; 0.001). Subgroup analysis based on the International Staging System and sex revealed similar relationships ( p & lt; 0.01). When stratified by age, patients with HR & gt;100 bpm had higher all-cause mortality than those with a lower HR when age was & lt;65 years or 65–75 years ( p & lt; 0.001) but not & gt;75 years. The proportion of patients with hypertension was 54.7% (211/386). However, hypertension was not associated with all-cause mortality in MM patients (χ 2 =1.729, p & gt; 0.05). MM patients with HR & gt;100 bpm had the highest all-cause mortality. Conclusions: The prognostic potential of HR may be useful in aiding risk stratification and promoting the management of these patients.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2021.681484
    DOI: 10.3389/fcvm.2021.681484.s001
    DOI: 10.3389/fcvm.2021.681484.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 3
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    Effective mobilization with etoposide and cyclophosphamide for collection of peripheral blood stem cell in patients with multiple myeloma
    University of Toronto Libraries - UOTL ; 2020
    In:  Clinical and Investigative Medicine Vol. 43, No. 3 ( 2020-09-24), p. E27-32
    Details
    In: Clinical and Investigative Medicine, University of Toronto Libraries - UOTL, Vol. 43, No. 3 ( 2020-09-24), p. E27-32
    Abstract: Purpose: To evaluate the efficacy and toxicity of etoposide and cyclophosphamide for mobilization peripheral stem cells in multiple myeloma patients. Methods: We retrospectively analyzed 46 patients with multiple myeloma who underwent peripheral blood stem cell collection for upfront autologous hematopoietic stem cell transplantation in the First Affiliated Hospital of Xi’an Jiaotong University between January 2010 and July 2019. The mobilization protocols included cyclophosphamide 2.0 g/m2 with G-CSF (CTX group) before January 2015, and two-days of 5 mg/kg.d etoposide and 1.0 g/m2.d cyclophosphamide with G-CSF (EC group) after January 2015. Results: The success rate of harvest (≥2×106 cells/kg) during the first mobilization attempt was 82.1% in the EC group and 50.0% in the CTX group, and the rate of adequate harvest (≥4×106 cells/kg) was 57.1% in the EC group and 15.8% in the CTX group. After the second mobilization, a sufficient number of CD34+/kg cells for an auto-HSCT was obtained for all patients in the EC group and the majority (68.4%) of patients in CTX group. There was no significant difference of non-hematological adverse events between two groups. The mean neutrophil engraftment time was 11.22±1.56 days and 9.89±2.81days for the CTX and EC groups, respectively (P 〉 0.05). Platelet engraftments were significantly faster in the EC group than the CTX group (P0.05). Conclusion: The etoposide and cyclophosphamide regimen could be an effective and safe method for mobilization in patients with multiple myeloma.
    Type of Medium: Online Resource
    ISSN: 1488-2353
    URL: Article
    DOI: 10.25011/cim.v43i3.34643
    Language: Unknown
    Publisher: University of Toronto Libraries - UOTL
    Publication Date: 2020
    detail.hit.zdb_id: 2067562-8
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  • 4
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    Post-flowering Soil Waterlogging Curtails Grain Yield Formation by Restricting Assimilates Supplies to Developing Grains
    Frontiers Media SA ; 2022
    In:  Frontiers in Plant Science Vol. 13 ( 2022-6-17)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-6-17)
    Abstract: Soil waterlogging is among the major factors limiting the grain yield of winter wheat crops in many parts of the world, including the middle and lower reaches of the Yangtze River China. In a field study, we investigated the relationship between leaf physiology and grain development under a varying duration of post-flowering waterlogging. A winter wheat cultivar Ningmai 13 was exposed to soil waterlogging for 0 (W0), 3 (W3), 6 (W6), and 9 d (W9) at anthesis. Increasing waterlogging duration significantly reduced flag leaf SPAD (soil plant analysis development) values and net photosynthetic rate (Pn). There was a linear reduction in flag leaf Pn and SPAD as plant growth progressed under all treatments; however, the speed of damage was greater in the waterlogged leaves. For example, compared with their respective control (W0), flag leaves of W9 treatment have experienced 46% more reduction in Pn at 21 d after anthesis (DAA) than at 7 DAA. Increasing waterlogging duration also induced oxidative damage in flag leaves, measured as malondialdehyde (MDA) contents. The capacity to overcome this oxidative damage was limited by the poor performance of antioxidant enzymes in wheat leaves. Inhibited leaf Pn and capacity to sustain assimilate synthesis under waterlogged environments reduced grain development. Compared with W0, W6 and W9 plants experienced a 20 and 22% reduction in thousand grain weight (TGW) in response to W6 and W9, respectively at 7 DAA and 11 and 19%, respectively at 28 DAA. Sustained waterlogging also significantly reduced grain number per spike and final grain yield. Averaged across two years of study, W9 plants produced 28% lesser final grain yield than W0 plants. Our study suggested that wheat crops are highly sensitive to soil waterlogging during reproductive and grain filling phases due to their poor capacity to recover from oxidative injury to photosynthesis. Management strategies such as planting time, fertilization and genotype selection should be considered for the areas experiencing frequent waterlogging problems.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    DOI: 10.3389/fpls.2022.944308
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 5
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    Table_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Immunology Vol. 12 ( 2021-11-18)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-11-18)
    Abstract: The expression level of BCMA in bone marrow of 54 MM patients was detected in this study to explore the relationship between the BCMA expression and the classification, stage, and prognostic factors of MM. The BCMA expression level of the stable group and remission group was lower than that of the newly diagnosed group and relapse group (P=0.001). There was no significant difference in BCMA expression of MM patients in different types and stages (P & gt;0.05), but it was found that for the newly diagnosed MM patients, the BCMA expression level of IgG patients was higher than that of IgA or light-chain patients (rank average 11.20 vs 5.44, P=0.014). There was no significant correlation between the BCMA expression and the age and serum creatinine of MM patients (P & gt;0.05). And there was no significant difference in BCMA expression between patients with different levels of age and serum creatinine (P & gt;0.05). But it was found that the BCMA expression level of the newly diagnosed MM patients was moderately positively correlated with their age (P=0.025, r=0.595). There was no significant correlation between the BCMA expression and serum β2-microglobulin, serum lactate dehydrogenase, free kap/lam ratio, and urine β2-microglobulin (P & gt;0.05). But we found that the BCMA expression of patients with high serum β2-microglobulin was higher than that of patients with low serum β2-microglobulin (rank average 28.89 vs 17.54, P=0.017). And the BCMA expression of patients with abnormal serum free kap/lam ratio was higher than that of patients with normal ratio (rank average 28.49 vs 13.55, P=0.004). The BCMA expression was strongly positively correlated with 24-h urine protein, was moderately positively correlated with serum M protein and the percentage of plasma cells in bone marrow, was moderately negatively correlated with albumin and hemoglobin count, and was weakly positively correlated with serum corrected calcium (P & lt;0.05). And it was found that the BCMA expression of positive serum immunofixation electrophoresis patients was higher than that of negative patients (rank average 29.94 vs 16.75, P=0.017). And we try to clarify the relationship between the bone marrow BCMA expression and the peripheral blood sBCMA expression. However, we have not found a clear correlation between them so far (P & gt;0.05).
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2021.724411
    DOI: 10.3389/fimmu.2021.724411.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 6
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    Online Resource
    Is platelet-rich plasma better than hyaluronic acid in the treatment of knee osteoarthritis? A meta-analysis of RCTs
    Termedia Sp. z.o.o. ; 2022
    In:  Videosurgery and Other Miniinvasive Techniques Vol. 17, No. 4 ( 2022), p. 611-623
    Details
    In: Videosurgery and Other Miniinvasive Techniques, Termedia Sp. z.o.o., Vol. 17, No. 4 ( 2022), p. 611-623
    Type of Medium: Online Resource
    ISSN: 1895-4588
    URL: Article
    DOI: 10.5114/wiitm.2022.118777
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2022
    detail.hit.zdb_id: 2596147-0
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  • 7
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    Model improvement and SOC estimation based on aluminium ion batteries
    IOP Publishing ; 2021
    In:  Engineering Research Express Vol. 3, No. 1 ( 2021-03-01), p. 015038-
    Details
    In: Engineering Research Express, IOP Publishing, Vol. 3, No. 1 ( 2021-03-01), p. 015038-
    Abstract: The main work of this paper can be divided into three parts: (1) An aluminium ion battery is made, the battery capacity is calibrated under a constant current, and the battery’s voltage and current data under pulse conditions is collected. (2) The influence of the hysteresis effect on the SOC estimation of aluminium ion batteries is fully considered. A model suitable for aluminium ion batteries is established based on the model that the parameter identification and verification was carried out with. (3) The error with the EKF and AEKF algorithms in estimating the SOC of aluminium ion batteries is compared. The experimental results show that the model established in this paper can describe the working state of aluminium ion batteries very well. Compared with the EKF algorithm, the AEKF algorithm is more accurate in estimating the SOC of aluminium ion batteries.
    Type of Medium: Online Resource
    ISSN: 2631-8695
    URL: Article
    DOI: 10.1088/2631-8695/abe7d2
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2978952-7
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  • 8
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    Online Resource
    Job Dispatch Control for Production Lines With Overlapped Time Window Constraints
    Institute of Electrical and Electronics Engineers (IEEE) ; 2018
    In:  IEEE Transactions on Semiconductor Manufacturing Vol. 31, No. 2 ( 2018-5), p. 206-214
    Details
    In: IEEE Transactions on Semiconductor Manufacturing, Institute of Electrical and Electronics Engineers (IEEE), Vol. 31, No. 2 ( 2018-5), p. 206-214
    Type of Medium: Online Resource
    ISSN: 0894-6507 , 1558-2345
    URL: Article
    DOI: 10.1109/TSM.2018.2826530
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2018
    detail.hit.zdb_id: 2035198-7
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  • 9
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    Table_1.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychiatry Vol. 13 ( 2022-7-14)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-7-14)
    Abstract: Children and adolescents are at a high risk of major depressive disorder (MDD) with known sex differences in epidemiology. However, there are currently no objective laboratory-based sex-specific biomarkers available to support the diagnoses of male and female patients with MDD. Methods Here, a male set of 42 cases and 27 healthy controls (HCs) and a female set of 42 cases and 22 HCs were recruited. This study investigated the sex differences of plasma metabolite biomarkers in young patients with MDD by the application of ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry. Results The metabolic profiles showed clear separations in both male and female sets. In total, this study identified 57 male-related and 53 female-related differential metabolites. Compared with HCs, both male and female subjects with MDD displayed four significantly altered pathways. Notably, biliverdin was selected as an independent diagnostic male-specific biomarker with an area under the receiver operating characteristic curve of 0.966, and phosphatidylcholine (10:0/14:1) was selected as a female-specific biomarker, achieving an area under the curve (AUC) of 0.957. Conclusion This metabolomics study may aid in the development of a plasma-based test for the diagnosis of male and female children and adolescents with MDD, as well as give new insight into the pathophysiology of sex differences in children and adolescents with MDD.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    URL: Article
    DOI: 10.3389/fpsyt.2022.929207
    DOI: 10.3389/fpsyt.2022.929207.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
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